Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 1993078..1993716 Replicon chromosome
Accession NZ_AP026108
Organism Escherichia coli strain CEC13091

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag OO842_RS09905 Protein ID WP_000813794.1
Coordinates 1993078..1993254 (+) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag OO842_RS09910 Protein ID WP_001270286.1
Coordinates 1993300..1993716 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OO842_RS09885 (1988699) 1988699..1989872 - 1174 Protein_1943 BenE family transporter YdcO -
OO842_RS09890 (1989964) 1989964..1990500 + 537 WP_000429145.1 DNA-binding transcriptional regulator SutR -
OO842_RS09895 (1990573) 1990573..1992534 + 1962 WP_001303492.1 23S rRNA 5-hydroxycytidine C2501 synthase -
OO842_RS09900 (1992626) 1992626..1992856 - 231 WP_000494244.1 YncJ family protein -
OO842_RS09905 (1993078) 1993078..1993254 + 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
OO842_RS09910 (1993300) 1993300..1993716 + 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
OO842_RS09915 (1993795) 1993795..1995201 + 1407 WP_000760654.1 PLP-dependent aminotransferase family protein -
OO842_RS09920 (1995446) 1995446..1996591 + 1146 WP_000047432.1 ABC transporter substrate-binding protein -
OO842_RS09925 (1996609) 1996609..1997622 + 1014 WP_000220402.1 ABC transporter ATP-binding protein -
OO842_RS09930 (1997623) 1997623..1998564 + 942 WP_001251315.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T42245 WP_000813794.1 NZ_AP026108:1993078-1993254 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

>T42245 NZ_AP026108:1993078-1993254 [Escherichia coli]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTGAAACTCAG
GTTTCATGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT42245 WP_001270286.1 NZ_AP026108:1993300-1993716 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp

>AT42245 NZ_AP026108:1993300-1993716 [Escherichia coli]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
GCAGGGCGAAACTGTCGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCTTTACCTTCGCCATTAAATAGTCATGATCACTTTATTGAAGTACCTTTGAGCGTCGCCTCTAAGGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAAGAGAT
TACTCGCCTATTTAACTTGCATCATGCGACAAAAATCGACGCCGTCCAGCTCGCGGCAAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References