Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 1244541..1245019 Replicon chromosome
Accession NZ_AP026108
Organism Escherichia coli strain CEC13091

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A891SFN9
Locus tag OO842_RS05815 Protein ID WP_001303876.1
Coordinates 1244541..1244828 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID Q8XD67
Locus tag OO842_RS05820 Protein ID WP_000536233.1
Coordinates 1244828..1245019 (-) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OO842_RS05780 (1239690) 1239690..1242161 - 2472 WP_000034474.1 exonuclease -
OO842_RS05785 (1242255) 1242255..1242446 - 192 WP_001098307.1 DUF1482 family protein -
OO842_RS05790 (1242443) 1242443..1242631 - 189 WP_000413705.1 cell division inhibition protein DicB -
OO842_RS05795 (1243205) 1243205..1243390 + 186 WP_001133046.1 hypothetical protein -
OO842_RS05800 (1243577) 1243577..1243966 - 390 WP_000394511.1 hypothetical protein -
OO842_RS05805 (1243978) 1243978..1244106 - 129 WP_000344963.1 protein YdfB -
OO842_RS05810 (1244108) 1244108..1244263 - 156 WP_000379575.1 DUF1391 family protein -
OO842_RS05815 (1244541) 1244541..1244828 - 288 WP_001303876.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OO842_RS05820 (1244828) 1244828..1245019 - 192 WP_000536233.1 hypothetical protein Antitoxin
OO842_RS05825 (1245047) 1245047..1245448 - 402 WP_000986592.1 helix-turn-helix domain-containing protein -
OO842_RS05830 (1245557) 1245557..1245829 + 273 WP_000887453.1 YdaS family helix-turn-helix protein -
OO842_RS05835 (1245813) 1245813..1246238 + 426 WP_000693855.1 toxin YdaT family protein -
OO842_RS05840 (1246445) 1246445..1246900 - 456 WP_000273724.1 hypothetical protein -
OO842_RS05845 (1246979) 1246979..1248070 + 1092 WP_001205823.1 hypothetical protein -
OO842_RS05850 (1248077) 1248077..1248823 + 747 WP_000788745.1 ATP-binding protein -
OO842_RS05855 (1248845) 1248845..1249615 + 771 WP_000450992.1 DUF1627 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10978.84 Da        Isoelectric Point: 10.1360

>T42239 WP_001303876.1 NZ_AP026108:c1244828-1244541 [Escherichia coli]
MLPILWLPSARDDLRQIITYIAKENPPAARRLKIRIETSVLPLSEHPYLYPPSERVSGLREIVTHPNYIILYRVAASSIE
IVSVTHSRRQFPFSI

Download         Length: 288 bp

>T42239 NZ_AP026108:c1244828-1244541 [Escherichia coli]
ATGTTACCCATTTTATGGCTACCGTCTGCTCGCGATGATTTGCGCCAGATCATAACTTACATCGCCAAGGAGAACCCACC
GGCAGCACGTAGACTAAAAATACGCATTGAAACATCGGTATTACCTCTATCTGAGCATCCGTACTTATATCCACCAAGCG
AACGGGTTTCTGGATTGAGAGAGATCGTGACCCACCCTAACTACATAATCCTGTACAGAGTAGCTGCTTCAAGCATTGAG
ATTGTAAGCGTGACACATTCTCGGCGACAATTTCCCTTCTCTATCTGA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7025.80 Da        Isoelectric Point: 4.0270

>AT42239 WP_000536233.1 NZ_AP026108:c1245019-1244828 [Escherichia coli]
MGTALSPIVSEFETTEQENSYNEWLRTKVTSSLADTRPAIPHDEVMAEMENLIAQIAVTNKSE

Download         Length: 192 bp

>AT42239 NZ_AP026108:c1245019-1244828 [Escherichia coli]
ATGGGTACAGCCCTTTCTCCGATAGTTTCAGAATTCGAAACTACCGAACAAGAAAACAGTTACAACGAATGGTTGCGCAC
TAAAGTAACGTCAAGCCTTGCAGACACTCGCCCCGCAATTCCACATGACGAGGTAATGGCTGAAATGGAAAATCTTATTG
CTCAAATTGCTGTAACTAACAAGAGCGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References