Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1130098..1130933 Replicon chromosome
Accession NZ_AP026108
Organism Escherichia coli strain CEC13091

Toxin (Protein)


Gene name yeeV Uniprot ID A0A2A3UQ69
Locus tag OO842_RS05305 Protein ID WP_000854714.1
Coordinates 1130556..1130933 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A2A3UQI5
Locus tag OO842_RS05300 Protein ID WP_001285574.1
Coordinates 1130098..1130466 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OO842_RS05250 (1125680) 1125680..1125853 + 174 WP_001445295.1 hypothetical protein -
OO842_RS05255 (1125979) 1125979..1126518 + 540 WP_001104024.1 DUF4339 domain-containing protein -
OO842_RS05260 (1126788) 1126788..1127201 + 414 WP_000789534.1 hypothetical protein -
OO842_RS05265 (1127341) 1127341..1127480 - 140 Protein_1032 hypothetical protein -
OO842_RS05270 (1127450) 1127450..1127522 + 73 Protein_1033 hypothetical protein -
OO842_RS05275 (1127612) 1127612..1128430 + 819 WP_001234742.1 DUF932 domain-containing protein -
OO842_RS05280 (1128430) 1128430..1128675 + 246 WP_000680582.1 hypothetical protein -
OO842_RS05285 (1128769) 1128769..1129242 + 474 WP_001456342.1 antirestriction protein -
OO842_RS05290 (1129258) 1129258..1129734 + 477 WP_001186726.1 RadC family protein -
OO842_RS05295 (1129797) 1129797..1130018 + 222 WP_000692328.1 DUF987 domain-containing protein -
OO842_RS05300 (1130098) 1130098..1130466 + 369 WP_001285574.1 type IV toxin-antitoxin system cytoskeleton bundling-enhancing antitoxin CbeA Antitoxin
OO842_RS05305 (1130556) 1130556..1130933 + 378 WP_000854714.1 TA system toxin CbtA family protein Toxin
OO842_RS05310 (1130930) 1130930..1131418 + 489 WP_000761724.1 DUF5983 family protein -
OO842_RS05315 (1131430) 1131430..1131627 + 198 WP_000839249.1 DUF957 domain-containing protein -
OO842_RS05320 (1131712) 1131712..1132272 + 561 Protein_1043 DUF4942 domain-containing protein -
OO842_RS05325 (1132344) 1132344..1133348 + 1005 WP_001179707.1 IS110-like element ISSfl8 family transposase -
OO842_RS05330 (1133630) 1133630..1133911 + 282 Protein_1045 DUF4942 domain-containing protein -
OO842_RS05340 (1134402) 1134402..1134620 - 219 WP_001040187.1 translation initiation factor IF-1 -
OO842_RS05345 (1134905) 1134905..1135609 - 705 WP_001241680.1 leucyl/phenylalanyl-tRNA--protein transferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 1132344..1133348 1004


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14216.31 Da        Isoelectric Point: 7.8046

>T42238 WP_000854714.1 NZ_AP026108:1130556-1130933 [Escherichia coli]
MKTLPDTHVREASRCPSPVIIWQILLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVDNITLGKHPEAKR

Download         Length: 378 bp

>T42238 NZ_AP026108:1130556-1130933 [Escherichia coli]
ATGAAAACATTACCCGATACACACGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCATCATCTGGCAGATTCTGCTCAC
CCGACTGCTGGACCAGCACTACGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAGATAACATTACCCTGGGGAAGCATCCGGAGGCGAAACGATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13578.33 Da        Isoelectric Point: 6.3152

>AT42238 WP_001285574.1 NZ_AP026108:1130098-1130466 [Escherichia coli]
VSDTLPGTTHPDDNNDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCDADTLGSCGYVYLAVYPTPETKK

Download         Length: 369 bp

>AT42238 NZ_AP026108:1130098-1130466 [Escherichia coli]
GTGTCAGACACTCTCCCCGGGACAACGCATCCCGACGATAACAACGACCGCCCCTGGTGGGGGCTACCCTGCACCGTGAC
GCCCTGTTTTGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCAGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGACGCGGATGCGTACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTATATGCTAAAGGGCTGACCTGCGATGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACCCCCGAAACGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A3UQ69

Antitoxin

Source ID Structure
AlphaFold DB A0A2A3UQI5

References