Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | paaR-paaA-parE/- |
| Location | 2056333..2056804 | Replicon | chromosome |
| Accession | NZ_AP026106 | ||
| Organism | Escherichia coli strain CEC01311 | ||
Toxin (Protein)
| Gene name | parE_1 | Uniprot ID | A0A0D7C2L1 |
| Locus tag | OO831_RS10110 | Protein ID | WP_001303511.1 |
| Coordinates | 2056526..2056804 (+) | Length | 93 a.a. |
Antitoxin (Protein)
| Gene name | paaA | Uniprot ID | Q8XAD5 |
| Locus tag | OO831_RS10105 | Protein ID | WP_001302048.1 |
| Coordinates | 2056333..2056524 (+) | Length | 64 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| OO831_RS10065 (2051540) | 2051540..2052124 | - | 585 | WP_000206793.1 | DUF551 domain-containing protein | - |
| OO831_RS10070 (2052181) | 2052181..2052576 | - | 396 | WP_001118159.1 | DUF977 family protein | - |
| OO831_RS10075 (2052592) | 2052592..2053361 | - | 770 | Protein_1975 | DUF1627 domain-containing protein | - |
| OO831_RS10080 (2053387) | 2053387..2054127 | - | 741 | WP_000788938.1 | ATP-binding protein | - |
| OO831_RS10085 (2054134) | 2054134..2055096 | - | 963 | WP_000095669.1 | helix-turn-helix domain-containing protein | - |
| OO831_RS10090 (2055119) | 2055119..2055544 | - | 426 | WP_000693943.1 | toxin YdaT family protein | - |
| OO831_RS10095 (2055541) | 2055541..2055843 | - | 303 | WP_000172738.1 | transcriptional regulator | - |
| OO831_RS10100 (2055941) | 2055941..2056312 | + | 372 | WP_001169686.1 | hypothetical protein | - |
| OO831_RS10105 (2056333) | 2056333..2056524 | + | 192 | WP_001302048.1 | hypothetical protein | Antitoxin |
| OO831_RS10110 (2056526) | 2056526..2056804 | + | 279 | WP_001303511.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| OO831_RS10115 (2057156) | 2057156..2057455 | + | 300 | WP_001240334.1 | hypothetical protein | - |
| OO831_RS10120 (2057527) | 2057527..2057745 | + | 219 | WP_001171930.1 | protein YdfC | - |
| OO831_RS10125 (2058314) | 2058314..2058502 | + | 189 | WP_000449192.1 | cell division inhibition protein DicB | - |
| OO831_RS10130 (2058499) | 2058499..2058690 | + | 192 | WP_001090200.1 | DUF1482 family protein | - |
| OO831_RS10135 (2058783) | 2058783..2061254 | + | 2472 | WP_000048458.1 | exonuclease | - |
| OO831_RS10140 (2061327) | 2061327..2061578 | + | 252 | WP_000005552.1 | excisionase family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | nleG7' | 1966928..2071684 | 104756 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 93 a.a. Molecular weight: 10661.25 Da Isoelectric Point: 5.5647
>T42208 WP_001303511.1 NZ_AP026106:2056526-2056804 [Escherichia coli]
MLPVLWLESADTDLDDITSYIARFDIDAAERLWQRLRGCVLPLSEHPYLYPPSDRVPGLREIVAHPNYIILYRVTTSSVE
VVNVIHARRQFP
MLPVLWLESADTDLDDITSYIARFDIDAAERLWQRLRGCVLPLSEHPYLYPPSDRVPGLREIVAHPNYIILYRVTTSSVE
VVNVIHARRQFP
Download Length: 279 bp
>T42208 NZ_AP026106:2056526-2056804 [Escherichia coli]
ATGTTACCCGTGTTATGGCTTGAAAGCGCAGATACCGACCTAGATGATATAACTAGTTATATTGCTCGTTTCGACATAGA
TGCGGCTGAACGCTTATGGCAGCGATTAAGGGGTTGTGTGCTGCCGTTATCCGAACATCCGTATTTATACCCACCAAGCG
ACAGAGTACCTGGCTTGCGTGAGATTGTAGCCCACCCTAACTATATAATTCTATACCGCGTAACAACATCAAGCGTTGAA
GTAGTAAACGTGATCCACGCAAGACGCCAGTTTCCCTAA
ATGTTACCCGTGTTATGGCTTGAAAGCGCAGATACCGACCTAGATGATATAACTAGTTATATTGCTCGTTTCGACATAGA
TGCGGCTGAACGCTTATGGCAGCGATTAAGGGGTTGTGTGCTGCCGTTATCCGAACATCCGTATTTATACCCACCAAGCG
ACAGAGTACCTGGCTTGCGTGAGATTGTAGCCCACCCTAACTATATAATTCTATACCGCGTAACAACATCAAGCGTTGAA
GTAGTAAACGTGATCCACGCAAGACGCCAGTTTCCCTAA
Antitoxin
Download Length: 64 a.a. Molecular weight: 7463.47 Da Isoelectric Point: 8.6828
>AT42208 WP_001302048.1 NZ_AP026106:2056333-2056524 [Escherichia coli]
MNRALSPMVSEFETIEQENSYNEWLRAKVATSLADPRPAIPHDEVERRMAERFAKMRKERSKQ
MNRALSPMVSEFETIEQENSYNEWLRAKVATSLADPRPAIPHDEVERRMAERFAKMRKERSKQ
Download Length: 192 bp
>AT42208 NZ_AP026106:2056333-2056524 [Escherichia coli]
ATGAATAGAGCCCTTTCACCAATGGTTTCTGAATTTGAAACCATTGAACAAGAAAACAGTTACAACGAATGGCTGCGTGC
GAAAGTAGCAACGAGCCTTGCAGATCCGCGCCCAGCAATTCCCCATGACGAAGTTGAGCGCAGAATGGCAGAACGCTTTG
CTAAGATGCGCAAGGAACGGAGCAAGCAGTAA
ATGAATAGAGCCCTTTCACCAATGGTTTCTGAATTTGAAACCATTGAACAAGAAAACAGTTACAACGAATGGCTGCGTGC
GAAAGTAGCAACGAGCCTTGCAGATCCGCGCCCAGCAATTCCCCATGACGAAGTTGAGCGCAGAATGGCAGAACGCTTTG
CTAAGATGCGCAAGGAACGGAGCAAGCAGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|