Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 1835077..1835715 Replicon chromosome
Accession NZ_AP026106
Organism Escherichia coli strain CEC01311

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag OO831_RS08915 Protein ID WP_000813794.1
Coordinates 1835077..1835253 (+) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag OO831_RS08920 Protein ID WP_001270286.1
Coordinates 1835299..1835715 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OO831_RS08895 (1830698) 1830698..1831871 - 1174 Protein_1745 BenE family transporter YdcO -
OO831_RS08900 (1831963) 1831963..1832499 + 537 WP_000429145.1 DNA-binding transcriptional regulator SutR -
OO831_RS08905 (1832572) 1832572..1834533 + 1962 WP_001303492.1 23S rRNA 5-hydroxycytidine C2501 synthase -
OO831_RS08910 (1834625) 1834625..1834855 - 231 WP_000494244.1 YncJ family protein -
OO831_RS08915 (1835077) 1835077..1835253 + 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
OO831_RS08920 (1835299) 1835299..1835715 + 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
OO831_RS08925 (1835794) 1835794..1837200 + 1407 WP_000760654.1 PLP-dependent aminotransferase family protein -
OO831_RS08930 (1837445) 1837445..1838590 + 1146 WP_000047432.1 ABC transporter substrate-binding protein -
OO831_RS08935 (1838608) 1838608..1839621 + 1014 WP_000220402.1 ABC transporter ATP-binding protein -
OO831_RS08940 (1839622) 1839622..1840563 + 942 WP_001251315.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T42205 WP_000813794.1 NZ_AP026106:1835077-1835253 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

>T42205 NZ_AP026106:1835077-1835253 [Escherichia coli]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTGAAACTCAG
GTTTCATGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT42205 WP_001270286.1 NZ_AP026106:1835299-1835715 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp

>AT42205 NZ_AP026106:1835299-1835715 [Escherichia coli]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
GCAGGGCGAAACTGTCGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCTTTACCTTCGCCATTAAATAGTCATGATCACTTTATTGAAGTACCTTTGAGCGTCGCCTCTAAGGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAAGAGAT
TACTCGCCTATTTAACTTGCATCATGCGACAAAAATCGACGCCGTCCAGCTCGCGGCAAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References