Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 1241492..1241970 Replicon chromosome
Accession NZ_AP026106
Organism Escherichia coli strain CEC01311

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A891SFN9
Locus tag OO831_RS05805 Protein ID WP_001303876.1
Coordinates 1241492..1241779 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID Q8XD67
Locus tag OO831_RS05810 Protein ID WP_000536233.1
Coordinates 1241779..1241970 (-) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OO831_RS05770 (1236641) 1236641..1239112 - 2472 WP_000034474.1 exonuclease -
OO831_RS05775 (1239206) 1239206..1239397 - 192 WP_001098307.1 DUF1482 family protein -
OO831_RS05780 (1239394) 1239394..1239582 - 189 WP_000413705.1 cell division inhibition protein DicB -
OO831_RS05785 (1240156) 1240156..1240341 + 186 WP_001133046.1 hypothetical protein -
OO831_RS05790 (1240528) 1240528..1240917 - 390 WP_000394511.1 hypothetical protein -
OO831_RS05795 (1240929) 1240929..1241057 - 129 WP_000344963.1 protein YdfB -
OO831_RS05800 (1241059) 1241059..1241214 - 156 WP_000379575.1 DUF1391 family protein -
OO831_RS05805 (1241492) 1241492..1241779 - 288 WP_001303876.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OO831_RS05810 (1241779) 1241779..1241970 - 192 WP_000536233.1 hypothetical protein Antitoxin
OO831_RS05815 (1241998) 1241998..1242399 - 402 WP_000986592.1 helix-turn-helix domain-containing protein -
OO831_RS05820 (1242508) 1242508..1242780 + 273 WP_000887453.1 YdaS family helix-turn-helix protein -
OO831_RS05825 (1242764) 1242764..1243189 + 426 WP_000693855.1 toxin YdaT family protein -
OO831_RS05830 (1243396) 1243396..1243851 - 456 WP_000273724.1 hypothetical protein -
OO831_RS05835 (1243930) 1243930..1245021 + 1092 WP_001205823.1 hypothetical protein -
OO831_RS05840 (1245028) 1245028..1245774 + 747 WP_000788745.1 ATP-binding protein -
OO831_RS05845 (1245796) 1245796..1246566 + 771 WP_000450992.1 DUF1627 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10978.84 Da        Isoelectric Point: 10.1360

>T42200 WP_001303876.1 NZ_AP026106:c1241779-1241492 [Escherichia coli]
MLPILWLPSARDDLRQIITYIAKENPPAARRLKIRIETSVLPLSEHPYLYPPSERVSGLREIVTHPNYIILYRVAASSIE
IVSVTHSRRQFPFSI

Download         Length: 288 bp

>T42200 NZ_AP026106:c1241779-1241492 [Escherichia coli]
ATGTTACCCATTTTATGGCTACCGTCTGCTCGCGATGATTTGCGCCAGATCATAACTTACATCGCCAAGGAGAACCCACC
GGCAGCACGTAGACTAAAAATACGCATTGAAACATCGGTATTACCTCTATCTGAGCATCCGTACTTATATCCACCAAGCG
AACGGGTTTCTGGATTGAGAGAGATCGTGACCCACCCTAACTACATAATCCTGTACAGAGTAGCTGCTTCAAGCATTGAG
ATTGTAAGCGTGACACATTCTCGGCGACAATTTCCCTTCTCTATCTGA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7025.80 Da        Isoelectric Point: 4.0270

>AT42200 WP_000536233.1 NZ_AP026106:c1241970-1241779 [Escherichia coli]
MGTALSPIVSEFETTEQENSYNEWLRTKVTSSLADTRPAIPHDEVMAEMENLIAQIAVTNKSE

Download         Length: 192 bp

>AT42200 NZ_AP026106:c1241970-1241779 [Escherichia coli]
ATGGGTACAGCCCTTTCTCCGATAGTTTCAGAATTCGAAACTACCGAACAAGAAAACAGTTACAACGAATGGTTGCGCAC
TAAAGTAACGTCAAGCCTTGCAGACACTCGCCCCGCAATTCCACATGACGAGGTAATGGCTGAAATGGAAAATCTTATTG
CTCAAATTGCTGTAACTAACAAGAGCGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References