Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 1822030..1822668 Replicon chromosome
Accession NZ_AP026104
Organism Escherichia coli strain CEC96047

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag OO843_RS08865 Protein ID WP_000813794.1
Coordinates 1822492..1822668 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag OO843_RS08860 Protein ID WP_001270286.1
Coordinates 1822030..1822446 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OO843_RS08840 (1817182) 1817182..1818123 - 942 WP_001251315.1 ABC transporter permease -
OO843_RS08845 (1818124) 1818124..1819137 - 1014 WP_000220402.1 ABC transporter ATP-binding protein -
OO843_RS08850 (1819155) 1819155..1820300 - 1146 WP_000047432.1 ABC transporter substrate-binding protein -
OO843_RS08855 (1820545) 1820545..1821951 - 1407 WP_000760654.1 PLP-dependent aminotransferase family protein -
OO843_RS08860 (1822030) 1822030..1822446 - 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
OO843_RS08865 (1822492) 1822492..1822668 - 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
OO843_RS08870 (1822890) 1822890..1823120 + 231 WP_000494244.1 YncJ family protein -
OO843_RS08875 (1823212) 1823212..1825173 - 1962 WP_001303492.1 23S rRNA 5-hydroxycytidine C2501 synthase -
OO843_RS08880 (1825246) 1825246..1825782 - 537 WP_000429145.1 DNA-binding transcriptional regulator SutR -
OO843_RS08885 (1825874) 1825874..1827047 + 1174 Protein_1743 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T42177 WP_000813794.1 NZ_AP026104:c1822668-1822492 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

>T42177 NZ_AP026104:c1822668-1822492 [Escherichia coli]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTGAAACTCAG
GTTTCATGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT42177 WP_001270286.1 NZ_AP026104:c1822446-1822030 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp

>AT42177 NZ_AP026104:c1822446-1822030 [Escherichia coli]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
GCAGGGCGAAACTGTCGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCTTTACCTTCGCCATTAAATAGTCATGATCACTTTATTGAAGTACCTTTGAGCGTCGCCTCTAAGGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAAGAGAT
TACTCGCCTATTTAACTTGCATCATGCGACAAAAATCGACGCCGTCCAGCTCGCGGCAAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References