Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | paaR-paaA-parE/- |
| Location | 1648352..1648823 | Replicon | chromosome |
| Accession | NZ_AP026104 | ||
| Organism | Escherichia coli strain CEC96047 | ||
Toxin (Protein)
| Gene name | parE_1 | Uniprot ID | A0A0D7C2L1 |
| Locus tag | OO843_RS08005 | Protein ID | WP_001303511.1 |
| Coordinates | 1648352..1648630 (-) | Length | 93 a.a. |
Antitoxin (Protein)
| Gene name | paaA | Uniprot ID | Q8XAD5 |
| Locus tag | OO843_RS08010 | Protein ID | WP_001302048.1 |
| Coordinates | 1648632..1648823 (-) | Length | 64 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| OO843_RS07980 (1645287) | 1645287..1646372 | - | 1086 | Protein_1566 | exonuclease | - |
| OO843_RS07985 (1646465) | 1646465..1646656 | - | 192 | WP_001090200.1 | DUF1482 family protein | - |
| OO843_RS07990 (1646653) | 1646653..1646841 | - | 189 | WP_000449192.1 | cell division inhibition protein DicB | - |
| OO843_RS07995 (1647410) | 1647410..1647628 | - | 219 | WP_001171930.1 | protein YdfC | - |
| OO843_RS08000 (1647700) | 1647700..1647999 | - | 300 | WP_001240334.1 | hypothetical protein | - |
| OO843_RS08005 (1648352) | 1648352..1648630 | - | 279 | WP_001303511.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| OO843_RS08010 (1648632) | 1648632..1648823 | - | 192 | WP_001302048.1 | hypothetical protein | Antitoxin |
| OO843_RS08015 (1648844) | 1648844..1649215 | - | 372 | WP_001169686.1 | hypothetical protein | - |
| OO843_RS08020 (1649313) | 1649313..1649615 | + | 303 | WP_000172738.1 | transcriptional regulator | - |
| OO843_RS08025 (1649612) | 1649612..1650037 | + | 426 | WP_000693943.1 | toxin YdaT family protein | - |
| OO843_RS08030 (1650060) | 1650060..1651022 | + | 963 | WP_000095669.1 | helix-turn-helix domain-containing protein | - |
| OO843_RS08035 (1651029) | 1651029..1651769 | + | 741 | WP_000788938.1 | ATP-binding protein | - |
| OO843_RS08040 (1651795) | 1651795..1652564 | + | 770 | Protein_1578 | DUF1627 domain-containing protein | - |
| OO843_RS08045 (1652580) | 1652580..1652975 | + | 396 | WP_001118159.1 | DUF977 family protein | - |
| OO843_RS08050 (1653032) | 1653032..1653616 | + | 585 | WP_000206793.1 | DUF551 domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 1639878..1690809 | 50931 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 93 a.a. Molecular weight: 10661.25 Da Isoelectric Point: 5.5647
>T42176 WP_001303511.1 NZ_AP026104:c1648630-1648352 [Escherichia coli]
MLPVLWLESADTDLDDITSYIARFDIDAAERLWQRLRGCVLPLSEHPYLYPPSDRVPGLREIVAHPNYIILYRVTTSSVE
VVNVIHARRQFP
MLPVLWLESADTDLDDITSYIARFDIDAAERLWQRLRGCVLPLSEHPYLYPPSDRVPGLREIVAHPNYIILYRVTTSSVE
VVNVIHARRQFP
Download Length: 279 bp
>T42176 NZ_AP026104:c1648630-1648352 [Escherichia coli]
ATGTTACCCGTGTTATGGCTTGAAAGCGCAGATACCGACCTAGATGATATAACTAGTTATATTGCTCGTTTCGACATAGA
TGCGGCTGAACGCTTATGGCAGCGATTAAGGGGTTGTGTGCTGCCGTTATCCGAACATCCGTATTTATACCCACCAAGCG
ACAGAGTACCTGGCTTGCGTGAGATTGTAGCCCACCCTAACTATATAATTCTATACCGCGTAACAACATCAAGCGTTGAA
GTAGTAAACGTGATCCACGCAAGACGCCAGTTTCCCTAA
ATGTTACCCGTGTTATGGCTTGAAAGCGCAGATACCGACCTAGATGATATAACTAGTTATATTGCTCGTTTCGACATAGA
TGCGGCTGAACGCTTATGGCAGCGATTAAGGGGTTGTGTGCTGCCGTTATCCGAACATCCGTATTTATACCCACCAAGCG
ACAGAGTACCTGGCTTGCGTGAGATTGTAGCCCACCCTAACTATATAATTCTATACCGCGTAACAACATCAAGCGTTGAA
GTAGTAAACGTGATCCACGCAAGACGCCAGTTTCCCTAA
Antitoxin
Download Length: 64 a.a. Molecular weight: 7463.47 Da Isoelectric Point: 8.6828
>AT42176 WP_001302048.1 NZ_AP026104:c1648823-1648632 [Escherichia coli]
MNRALSPMVSEFETIEQENSYNEWLRAKVATSLADPRPAIPHDEVERRMAERFAKMRKERSKQ
MNRALSPMVSEFETIEQENSYNEWLRAKVATSLADPRPAIPHDEVERRMAERFAKMRKERSKQ
Download Length: 192 bp
>AT42176 NZ_AP026104:c1648823-1648632 [Escherichia coli]
ATGAATAGAGCCCTTTCACCAATGGTTTCTGAATTTGAAACCATTGAACAAGAAAACAGTTACAACGAATGGCTGCGTGC
GAAAGTAGCAACGAGCCTTGCAGATCCGCGCCCAGCAATTCCCCATGACGAAGTTGAGCGCAGAATGGCAGAACGCTTTG
CTAAGATGCGCAAGGAACGGAGCAAGCAGTAA
ATGAATAGAGCCCTTTCACCAATGGTTTCTGAATTTGAAACCATTGAACAAGAAAACAGTTACAACGAATGGCTGCGTGC
GAAAGTAGCAACGAGCCTTGCAGATCCGCGCCCAGCAATTCCCCATGACGAAGTTGAGCGCAGAATGGCAGAACGCTTTG
CTAAGATGCGCAAGGAACGGAGCAAGCAGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|