Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 1180687..1181165 Replicon chromosome
Accession NZ_AP026104
Organism Escherichia coli strain CEC96047

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A891SFN9
Locus tag OO843_RS05490 Protein ID WP_001303876.1
Coordinates 1180687..1180974 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID Q8XD67
Locus tag OO843_RS05495 Protein ID WP_000536233.1
Coordinates 1180974..1181165 (-) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OO843_RS05455 (1175836) 1175836..1178307 - 2472 WP_000034474.1 exonuclease -
OO843_RS05460 (1178401) 1178401..1178592 - 192 WP_001098307.1 DUF1482 family protein -
OO843_RS05465 (1178589) 1178589..1178777 - 189 WP_000413705.1 cell division inhibition protein DicB -
OO843_RS05470 (1179351) 1179351..1179536 + 186 WP_001133046.1 hypothetical protein -
OO843_RS05475 (1179723) 1179723..1180112 - 390 WP_000394511.1 hypothetical protein -
OO843_RS05480 (1180124) 1180124..1180252 - 129 WP_000344963.1 protein YdfB -
OO843_RS05485 (1180254) 1180254..1180409 - 156 WP_000379575.1 DUF1391 family protein -
OO843_RS05490 (1180687) 1180687..1180974 - 288 WP_001303876.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OO843_RS05495 (1180974) 1180974..1181165 - 192 WP_000536233.1 hypothetical protein Antitoxin
OO843_RS05500 (1181193) 1181193..1181594 - 402 WP_000986592.1 helix-turn-helix domain-containing protein -
OO843_RS05505 (1181703) 1181703..1181975 + 273 WP_000887453.1 YdaS family helix-turn-helix protein -
OO843_RS05510 (1181959) 1181959..1182384 + 426 WP_000693855.1 toxin YdaT family protein -
OO843_RS05515 (1182591) 1182591..1183046 - 456 WP_000273724.1 hypothetical protein -
OO843_RS05520 (1183125) 1183125..1184216 + 1092 WP_001205823.1 hypothetical protein -
OO843_RS05525 (1184223) 1184223..1184969 + 747 WP_000788745.1 ATP-binding protein -
OO843_RS05530 (1184991) 1184991..1185761 + 771 WP_000450992.1 DUF1627 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10978.84 Da        Isoelectric Point: 10.1360

>T42167 WP_001303876.1 NZ_AP026104:c1180974-1180687 [Escherichia coli]
MLPILWLPSARDDLRQIITYIAKENPPAARRLKIRIETSVLPLSEHPYLYPPSERVSGLREIVTHPNYIILYRVAASSIE
IVSVTHSRRQFPFSI

Download         Length: 288 bp

>T42167 NZ_AP026104:c1180974-1180687 [Escherichia coli]
ATGTTACCCATTTTATGGCTACCGTCTGCTCGCGATGATTTGCGCCAGATCATAACTTACATCGCCAAGGAGAACCCACC
GGCAGCACGTAGACTAAAAATACGCATTGAAACATCGGTATTACCTCTATCTGAGCATCCGTACTTATATCCACCAAGCG
AACGGGTTTCTGGATTGAGAGAGATCGTGACCCACCCTAACTACATAATCCTGTACAGAGTAGCTGCTTCAAGCATTGAG
ATTGTAAGCGTGACACATTCTCGGCGACAATTTCCCTTCTCTATCTGA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7025.80 Da        Isoelectric Point: 4.0270

>AT42167 WP_000536233.1 NZ_AP026104:c1181165-1180974 [Escherichia coli]
MGTALSPIVSEFETTEQENSYNEWLRTKVTSSLADTRPAIPHDEVMAEMENLIAQIAVTNKSE

Download         Length: 192 bp

>AT42167 NZ_AP026104:c1181165-1180974 [Escherichia coli]
ATGGGTACAGCCCTTTCTCCGATAGTTTCAGAATTCGAAACTACCGAACAAGAAAACAGTTACAACGAATGGTTGCGCAC
TAAAGTAACGTCAAGCCTTGCAGACACTCGCCCCGCAATTCCACATGACGAGGTAATGGCTGAAATGGAAAATCTTATTG
CTCAAATTGCTGTAACTAACAAGAGCGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References