Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 1873292..1873930 Replicon chromosome
Accession NZ_AP026101
Organism Escherichia coli strain 93_161312

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag OO868_RS09200 Protein ID WP_000813794.1
Coordinates 1873754..1873930 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag OO868_RS09195 Protein ID WP_001270286.1
Coordinates 1873292..1873708 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OO868_RS09175 (1868444) 1868444..1869385 - 942 WP_001251315.1 ABC transporter permease -
OO868_RS09180 (1869386) 1869386..1870399 - 1014 WP_000220402.1 ABC transporter ATP-binding protein -
OO868_RS09185 (1870417) 1870417..1871562 - 1146 WP_000047432.1 ABC transporter substrate-binding protein -
OO868_RS09190 (1871807) 1871807..1873213 - 1407 WP_000760654.1 PLP-dependent aminotransferase family protein -
OO868_RS09195 (1873292) 1873292..1873708 - 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
OO868_RS09200 (1873754) 1873754..1873930 - 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
OO868_RS09205 (1874152) 1874152..1874382 + 231 WP_000494244.1 YncJ family protein -
OO868_RS09210 (1874474) 1874474..1876435 - 1962 WP_001303492.1 23S rRNA 5-hydroxycytidine C2501 synthase -
OO868_RS09215 (1876508) 1876508..1877044 - 537 WP_000429145.1 DNA-binding transcriptional regulator SutR -
OO868_RS09220 (1877136) 1877136..1878309 + 1174 Protein_1807 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T42143 WP_000813794.1 NZ_AP026101:c1873930-1873754 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

>T42143 NZ_AP026101:c1873930-1873754 [Escherichia coli]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTGAAACTCAG
GTTTCATGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT42143 WP_001270286.1 NZ_AP026101:c1873708-1873292 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp

>AT42143 NZ_AP026101:c1873708-1873292 [Escherichia coli]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
GCAGGGCGAAACTGTCGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCTTTACCTTCGCCATTAAATAGTCATGATCACTTTATTGAAGTACCTTTGAGCGTCGCCTCTAAGGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAAGAGAT
TACTCGCCTATTTAACTTGCATCATGCGACAAAAATCGACGCCGTCCAGCTCGCGGCAAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References