Detailed information of TA system TA042129

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): paaR-paaA-parE/-
• Location: 1173334..1173812
• Replicon: chromosome
• Accession: NZ_AP026101
• Organism: Escherichia coli strain 93_161312

Toxin (Protein)

• Gene name: parE_1
• Uniprot ID: A0A891SFN9
• Locus tag: OO868_RS05420
• Protein ID: WP_001303876.1
• Coordinates: 1173334..1173621 (-)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: paaA
• Uniprot ID: Q8XD67
• Locus tag: OO868_RS05425
• Protein ID: WP_000536233.1
• Coordinates: 1173621..1173812 (-)
• Length: 64 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
OO868_RS05385 (1168495)	1168495..1170966	-	2472	WP_000034474.1	exonuclease	-
OO868_RS05390 (1171060)	1171060..1171251	-	192	WP_001098307.1	DUF1482 family protein	-
OO868_RS05395 (1171248)	1171248..1171436	-	189	WP_000413705.1	cell division inhibition protein DicB	-
OO868_RS05400 (1171998)	1171998..1172183	+	186	WP_001133046.1	hypothetical protein	-
OO868_RS05405 (1172370)	1172370..1172759	-	390	WP_000394511.1	hypothetical protein	-
OO868_RS05410 (1172771)	1172771..1172899	-	129	WP_000344963.1	protein YdfB	-
OO868_RS05415 (1172901)	1172901..1173056	-	156	WP_000379575.1	DUF1391 family protein	-
OO868_RS05420 (1173334)	1173334..1173621	-	288	WP_001303876.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
OO868_RS05425 (1173621)	1173621..1173812	-	192	WP_000536233.1	hypothetical protein	Antitoxin
OO868_RS05430 (1173840)	1173840..1174241	-	402	WP_000986592.1	helix-turn-helix domain-containing protein	-
OO868_RS05435 (1174350)	1174350..1174622	+	273	WP_000887453.1	YdaS family helix-turn-helix protein	-
OO868_RS05440 (1174606)	1174606..1175031	+	426	WP_000693855.1	toxin YdaT family protein	-
OO868_RS05445 (1175238)	1175238..1175693	-	456	WP_000273724.1	hypothetical protein	-
OO868_RS05450 (1175772)	1175772..1176863	+	1092	WP_001205823.1	hypothetical protein	-
OO868_RS05455 (1176870)	1176870..1177616	+	747	WP_000788745.1	ATP-binding protein	-
OO868_RS05460 (1177638)	1177638..1178408	+	771	WP_000450992.1	DUF1627 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-91)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 10978.84 Da
• Isoelectric Point: 10.1360

>T42129 WP_001303876.1 NZ_AP026101:c1173621-1173334 [Escherichia coli]
MLPILWLPSARDDLRQIITYIAKENPPAARRLKIRIETSVLPLSEHPYLYPPSERVSGLREIVTHPNYIILYRVAASSIE
IVSVTHSRRQFPFSI

Nucleotide

• Length: 288 bp

>T42129 NZ_AP026101:c1173621-1173334 [Escherichia coli]
ATGTTACCCATTTTATGGCTACCGTCTGCTCGCGATGATTTGCGCCAGATCATAACTTACATCGCCAAGGAGAACCCACC
GGCAGCACGTAGACTAAAAATACGCATTGAAACATCGGTATTACCTCTATCTGAGCATCCGTACTTATATCCACCAAGCG
AACGGGTTTCTGGATTGAGAGAGATCGTGACCCACCCTAACTACATAATCCTGTACAGAGTAGCTGCTTCAAGCATTGAG
ATTGTAAGCGTGACACATTCTCGGCGACAATTTCCCTTCTCTATCTGA

Antitoxin

Protein

• Length: 64 a.a.
• Molecular weight: 7025.80 Da
• Isoelectric Point: 4.0270

>AT42129 WP_000536233.1 NZ_AP026101:c1173812-1173621 [Escherichia coli]
MGTALSPIVSEFETTEQENSYNEWLRTKVTSSLADTRPAIPHDEVMAEMENLIAQIAVTNKSE

Nucleotide

• Length: 192 bp

>AT42129 NZ_AP026101:c1173812-1173621 [Escherichia coli]
ATGGGTACAGCCCTTTCTCCGATAGTTTCAGAATTCGAAACTACCGAACAAGAAAACAGTTACAACGAATGGTTGCGCAC
TAAAGTAACGTCAAGCCTTGCAGACACTCGCCCCGCAATTCCACATGACGAGGTAATGGCTGAAATGGAAAATCTTATTG
CTCAAATTGCTGTAACTAACAAGAGCGAGTAA