Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 1173334..1173812 Replicon chromosome
Accession NZ_AP026101
Organism Escherichia coli strain 93_161312

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A891SFN9
Locus tag OO868_RS05420 Protein ID WP_001303876.1
Coordinates 1173334..1173621 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID Q8XD67
Locus tag OO868_RS05425 Protein ID WP_000536233.1
Coordinates 1173621..1173812 (-) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OO868_RS05385 (1168495) 1168495..1170966 - 2472 WP_000034474.1 exonuclease -
OO868_RS05390 (1171060) 1171060..1171251 - 192 WP_001098307.1 DUF1482 family protein -
OO868_RS05395 (1171248) 1171248..1171436 - 189 WP_000413705.1 cell division inhibition protein DicB -
OO868_RS05400 (1171998) 1171998..1172183 + 186 WP_001133046.1 hypothetical protein -
OO868_RS05405 (1172370) 1172370..1172759 - 390 WP_000394511.1 hypothetical protein -
OO868_RS05410 (1172771) 1172771..1172899 - 129 WP_000344963.1 protein YdfB -
OO868_RS05415 (1172901) 1172901..1173056 - 156 WP_000379575.1 DUF1391 family protein -
OO868_RS05420 (1173334) 1173334..1173621 - 288 WP_001303876.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OO868_RS05425 (1173621) 1173621..1173812 - 192 WP_000536233.1 hypothetical protein Antitoxin
OO868_RS05430 (1173840) 1173840..1174241 - 402 WP_000986592.1 helix-turn-helix domain-containing protein -
OO868_RS05435 (1174350) 1174350..1174622 + 273 WP_000887453.1 YdaS family helix-turn-helix protein -
OO868_RS05440 (1174606) 1174606..1175031 + 426 WP_000693855.1 toxin YdaT family protein -
OO868_RS05445 (1175238) 1175238..1175693 - 456 WP_000273724.1 hypothetical protein -
OO868_RS05450 (1175772) 1175772..1176863 + 1092 WP_001205823.1 hypothetical protein -
OO868_RS05455 (1176870) 1176870..1177616 + 747 WP_000788745.1 ATP-binding protein -
OO868_RS05460 (1177638) 1177638..1178408 + 771 WP_000450992.1 DUF1627 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10978.84 Da        Isoelectric Point: 10.1360

>T42129 WP_001303876.1 NZ_AP026101:c1173621-1173334 [Escherichia coli]
MLPILWLPSARDDLRQIITYIAKENPPAARRLKIRIETSVLPLSEHPYLYPPSERVSGLREIVTHPNYIILYRVAASSIE
IVSVTHSRRQFPFSI

Download         Length: 288 bp

>T42129 NZ_AP026101:c1173621-1173334 [Escherichia coli]
ATGTTACCCATTTTATGGCTACCGTCTGCTCGCGATGATTTGCGCCAGATCATAACTTACATCGCCAAGGAGAACCCACC
GGCAGCACGTAGACTAAAAATACGCATTGAAACATCGGTATTACCTCTATCTGAGCATCCGTACTTATATCCACCAAGCG
AACGGGTTTCTGGATTGAGAGAGATCGTGACCCACCCTAACTACATAATCCTGTACAGAGTAGCTGCTTCAAGCATTGAG
ATTGTAAGCGTGACACATTCTCGGCGACAATTTCCCTTCTCTATCTGA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7025.80 Da        Isoelectric Point: 4.0270

>AT42129 WP_000536233.1 NZ_AP026101:c1173812-1173621 [Escherichia coli]
MGTALSPIVSEFETTEQENSYNEWLRTKVTSSLADTRPAIPHDEVMAEMENLIAQIAVTNKSE

Download         Length: 192 bp

>AT42129 NZ_AP026101:c1173812-1173621 [Escherichia coli]
ATGGGTACAGCCCTTTCTCCGATAGTTTCAGAATTCGAAACTACCGAACAAGAAAACAGTTACAACGAATGGTTGCGCAC
TAAAGTAACGTCAAGCCTTGCAGACACTCGCCCCGCAATTCCACATGACGAGGTAATGGCTGAAATGGAAAATCTTATTG
CTCAAATTGCTGTAACTAACAAGAGCGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References