Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 2290498..2290969 Replicon chromosome
Accession NZ_AP026099
Organism Escherichia coli strain 61_150228

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A0D7C2L1
Locus tag OO862_RS11785 Protein ID WP_001303511.1
Coordinates 2290691..2290969 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID Q8XAD5
Locus tag OO862_RS11780 Protein ID WP_001302048.1
Coordinates 2290498..2290689 (+) Length 64 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OO862_RS11740 (2285705) 2285705..2286289 - 585 WP_000206793.1 DUF551 domain-containing protein -
OO862_RS11745 (2286346) 2286346..2286741 - 396 WP_001118159.1 DUF977 family protein -
OO862_RS11750 (2286757) 2286757..2287526 - 770 Protein_2306 DUF1627 domain-containing protein -
OO862_RS11755 (2287552) 2287552..2288292 - 741 WP_000788938.1 ATP-binding protein -
OO862_RS11760 (2288299) 2288299..2289261 - 963 WP_000095669.1 helix-turn-helix domain-containing protein -
OO862_RS11765 (2289284) 2289284..2289709 - 426 WP_000693943.1 toxin YdaT family protein -
OO862_RS11770 (2289706) 2289706..2290008 - 303 WP_000172738.1 transcriptional regulator -
OO862_RS11775 (2290106) 2290106..2290477 + 372 WP_001169686.1 hypothetical protein -
OO862_RS11780 (2290498) 2290498..2290689 + 192 WP_001302048.1 hypothetical protein Antitoxin
OO862_RS11785 (2290691) 2290691..2290969 + 279 WP_001303511.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OO862_RS11790 (2291321) 2291321..2291620 + 300 WP_001240334.1 hypothetical protein -
OO862_RS11795 (2291692) 2291692..2291910 + 219 WP_001171930.1 protein YdfC -
OO862_RS11800 (2292479) 2292479..2292667 + 189 WP_000449192.1 cell division inhibition protein DicB -
OO862_RS11805 (2292664) 2292664..2292855 + 192 WP_001090200.1 DUF1482 family protein -
OO862_RS11810 (2292948) 2292948..2295419 + 2472 WP_000048458.1 exonuclease -
OO862_RS11815 (2295492) 2295492..2295743 + 252 WP_000005552.1 excisionase family protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(4-91)

Antitoxin


No domain identified.



Sequences


Toxin        


Download         Length: 93 a.a.        Molecular weight: 10661.25 Da        Isoelectric Point: 5.5647

>T42103 WP_001303511.1 NZ_AP026099:2290691-2290969 [Escherichia coli]
MLPVLWLESADTDLDDITSYIARFDIDAAERLWQRLRGCVLPLSEHPYLYPPSDRVPGLREIVAHPNYIILYRVTTSSVE
VVNVIHARRQFP

Download         Length: 279 bp

>T42103 NZ_AP026099:2290691-2290969 [Escherichia coli]
ATGTTACCCGTGTTATGGCTTGAAAGCGCAGATACCGACCTAGATGATATAACTAGTTATATTGCTCGTTTCGACATAGA
TGCGGCTGAACGCTTATGGCAGCGATTAAGGGGTTGTGTGCTGCCGTTATCCGAACATCCGTATTTATACCCACCAAGCG
ACAGAGTACCTGGCTTGCGTGAGATTGTAGCCCACCCTAACTATATAATTCTATACCGCGTAACAACATCAAGCGTTGAA
GTAGTAAACGTGATCCACGCAAGACGCCAGTTTCCCTAA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7463.47 Da        Isoelectric Point: 8.6828

>AT42103 WP_001302048.1 NZ_AP026099:2290498-2290689 [Escherichia coli]
MNRALSPMVSEFETIEQENSYNEWLRAKVATSLADPRPAIPHDEVERRMAERFAKMRKERSKQ

Download         Length: 192 bp

>AT42103 NZ_AP026099:2290498-2290689 [Escherichia coli]
ATGAATAGAGCCCTTTCACCAATGGTTTCTGAATTTGAAACCATTGAACAAGAAAACAGTTACAACGAATGGCTGCGTGC
GAAAGTAGCAACGAGCCTTGCAGATCCGCGCCCAGCAATTCCCCATGACGAAGTTGAGCGCAGAATGGCAGAACGCTTTG
CTAAGATGCGCAAGGAACGGAGCAAGCAGTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
PDB 5CZF
PDB 5CW7
PDB 5CZE


Antitoxin

Source ID Structure
PDB 5CZF
PDB 3ZBE
PDB 5CW7
AlphaFold DB A0A829CTP0

References