Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 1221538..1222016 Replicon chromosome
Accession NZ_AP026099
Organism Escherichia coli strain 61_150228

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A891SFN9
Locus tag OO862_RS05795 Protein ID WP_001303876.1
Coordinates 1221538..1221825 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID Q8XD67
Locus tag OO862_RS05800 Protein ID WP_000536233.1
Coordinates 1221825..1222016 (-) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OO862_RS05760 (1216687) 1216687..1219158 - 2472 WP_000034474.1 exonuclease -
OO862_RS05765 (1219252) 1219252..1219443 - 192 WP_001098307.1 DUF1482 family protein -
OO862_RS05770 (1219440) 1219440..1219628 - 189 WP_000413705.1 cell division inhibition protein DicB -
OO862_RS05775 (1220202) 1220202..1220387 + 186 WP_001133046.1 hypothetical protein -
OO862_RS05780 (1220574) 1220574..1220963 - 390 WP_000394511.1 hypothetical protein -
OO862_RS05785 (1220975) 1220975..1221103 - 129 WP_000344963.1 protein YdfB -
OO862_RS05790 (1221105) 1221105..1221260 - 156 WP_000379575.1 DUF1391 family protein -
OO862_RS05795 (1221538) 1221538..1221825 - 288 WP_001303876.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OO862_RS05800 (1221825) 1221825..1222016 - 192 WP_000536233.1 hypothetical protein Antitoxin
OO862_RS05805 (1222044) 1222044..1222445 - 402 WP_000986592.1 helix-turn-helix domain-containing protein -
OO862_RS05810 (1222554) 1222554..1222826 + 273 WP_000887453.1 YdaS family helix-turn-helix protein -
OO862_RS05815 (1222810) 1222810..1223235 + 426 WP_000693855.1 toxin YdaT family protein -
OO862_RS05820 (1223442) 1223442..1223897 - 456 WP_000273724.1 hypothetical protein -
OO862_RS05825 (1223976) 1223976..1225067 + 1092 WP_001205823.1 hypothetical protein -
OO862_RS05830 (1225074) 1225074..1225820 + 747 WP_000788745.1 ATP-binding protein -
OO862_RS05835 (1225842) 1225842..1226612 + 771 WP_000450992.1 DUF1627 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10978.84 Da        Isoelectric Point: 10.1360

>T42100 WP_001303876.1 NZ_AP026099:c1221825-1221538 [Escherichia coli]
MLPILWLPSARDDLRQIITYIAKENPPAARRLKIRIETSVLPLSEHPYLYPPSERVSGLREIVTHPNYIILYRVAASSIE
IVSVTHSRRQFPFSI

Download         Length: 288 bp

>T42100 NZ_AP026099:c1221825-1221538 [Escherichia coli]
ATGTTACCCATTTTATGGCTACCGTCTGCTCGCGATGATTTGCGCCAGATCATAACTTACATCGCCAAGGAGAACCCACC
GGCAGCACGTAGACTAAAAATACGCATTGAAACATCGGTATTACCTCTATCTGAGCATCCGTACTTATATCCACCAAGCG
AACGGGTTTCTGGATTGAGAGAGATCGTGACCCACCCTAACTACATAATCCTGTACAGAGTAGCTGCTTCAAGCATTGAG
ATTGTAAGCGTGACACATTCTCGGCGACAATTTCCCTTCTCTATCTGA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7025.80 Da        Isoelectric Point: 4.0270

>AT42100 WP_000536233.1 NZ_AP026099:c1222016-1221825 [Escherichia coli]
MGTALSPIVSEFETTEQENSYNEWLRTKVTSSLADTRPAIPHDEVMAEMENLIAQIAVTNKSE

Download         Length: 192 bp

>AT42100 NZ_AP026099:c1222016-1221825 [Escherichia coli]
ATGGGTACAGCCCTTTCTCCGATAGTTTCAGAATTCGAAACTACCGAACAAGAAAACAGTTACAACGAATGGTTGCGCAC
TAAAGTAACGTCAAGCCTTGCAGACACTCGCCCCGCAATTCCACATGACGAGGTAATGGCTGAAATGGAAAATCTTATTG
CTCAAATTGCTGTAACTAACAAGAGCGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References