Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 2082010..2082481 Replicon chromosome
Accession NZ_AP026097
Organism Escherichia coli strain 57_142493

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A0D7C2L1
Locus tag OO832_RS10310 Protein ID WP_001303511.1
Coordinates 2082203..2082481 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID Q8XAD5
Locus tag OO832_RS10305 Protein ID WP_001302048.1
Coordinates 2082010..2082201 (+) Length 64 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OO832_RS10265 (2077215) 2077215..2077799 - 585 WP_000206793.1 DUF551 domain-containing protein -
OO832_RS10270 (2077856) 2077856..2078251 - 396 WP_001118159.1 DUF977 family protein -
OO832_RS10275 (2078267) 2078267..2079036 - 770 Protein_2015 DUF1627 domain-containing protein -
OO832_RS10280 (2079062) 2079062..2079802 - 741 WP_000788939.1 ATP-binding protein -
OO832_RS10285 (2079809) 2079809..2080771 - 963 WP_000095669.1 helix-turn-helix domain-containing protein -
OO832_RS10290 (2080794) 2080794..2081219 - 426 WP_000693943.1 toxin YdaT family protein -
OO832_RS10295 (2081216) 2081216..2081520 - 305 Protein_2019 transcriptional regulator -
OO832_RS10300 (2081618) 2081618..2081989 + 372 WP_001169686.1 hypothetical protein -
OO832_RS10305 (2082010) 2082010..2082201 + 192 WP_001302048.1 hypothetical protein Antitoxin
OO832_RS10310 (2082203) 2082203..2082481 + 279 WP_001303511.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OO832_RS10315 (2082833) 2082833..2083132 + 300 WP_001240334.1 hypothetical protein -
OO832_RS10320 (2083204) 2083204..2083422 + 219 WP_001171930.1 protein YdfC -
OO832_RS10325 (2083991) 2083991..2084179 + 189 WP_000449192.1 cell division inhibition protein DicB -
OO832_RS10330 (2084176) 2084176..2084367 + 192 WP_001090200.1 DUF1482 family protein -
OO832_RS10335 (2084460) 2084460..2085545 + 1086 Protein_2027 exonuclease -
OO832_RS10340 (2085596) 2085596..2086809 + 1214 WP_162829202.1 IS3-like element IS1203 family transposase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2040020..2098673 58653


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(4-91)

Antitoxin


No domain identified.



Sequences


Toxin        


Download         Length: 93 a.a.        Molecular weight: 10661.25 Da        Isoelectric Point: 5.5647

>T42070 WP_001303511.1 NZ_AP026097:2082203-2082481 [Escherichia coli]
MLPVLWLESADTDLDDITSYIARFDIDAAERLWQRLRGCVLPLSEHPYLYPPSDRVPGLREIVAHPNYIILYRVTTSSVE
VVNVIHARRQFP

Download         Length: 279 bp

>T42070 NZ_AP026097:2082203-2082481 [Escherichia coli]
ATGTTACCCGTGTTATGGCTTGAAAGCGCAGATACCGACCTAGATGATATAACTAGTTATATTGCTCGTTTCGACATAGA
TGCGGCTGAACGCTTATGGCAGCGATTAAGGGGTTGTGTGCTGCCGTTATCCGAACATCCGTATTTATACCCACCAAGCG
ACAGAGTACCTGGCTTGCGTGAGATTGTAGCCCACCCTAACTATATAATTCTATACCGCGTAACAACATCAAGCGTTGAA
GTAGTAAACGTGATCCACGCAAGACGCCAGTTTCCCTAA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7463.47 Da        Isoelectric Point: 8.6828

>AT42070 WP_001302048.1 NZ_AP026097:2082010-2082201 [Escherichia coli]
MNRALSPMVSEFETIEQENSYNEWLRAKVATSLADPRPAIPHDEVERRMAERFAKMRKERSKQ

Download         Length: 192 bp

>AT42070 NZ_AP026097:2082010-2082201 [Escherichia coli]
ATGAATAGAGCCCTTTCACCAATGGTTTCTGAATTTGAAACCATTGAACAAGAAAACAGTTACAACGAATGGCTGCGTGC
GAAAGTAGCAACGAGCCTTGCAGATCCGCGCCCAGCAATTCCCCATGACGAAGTTGAGCGCAGAATGGCAGAACGCTTTG
CTAAGATGCGCAAGGAACGGAGCAAGCAGTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
PDB 5CZF
PDB 5CW7
PDB 5CZE


Antitoxin

Source ID Structure
PDB 5CZF
PDB 3ZBE
PDB 5CW7
AlphaFold DB A0A829CTP0

References