Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 1172291..1172769 Replicon chromosome
Accession NZ_AP026097
Organism Escherichia coli strain 57_142493

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A891SFN9
Locus tag OO832_RS05415 Protein ID WP_001303876.1
Coordinates 1172291..1172578 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID Q8XD67
Locus tag OO832_RS05420 Protein ID WP_000536233.1
Coordinates 1172578..1172769 (-) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OO832_RS05380 (1167440) 1167440..1169911 - 2472 WP_000034474.1 exonuclease -
OO832_RS05385 (1170005) 1170005..1170196 - 192 WP_001098307.1 DUF1482 family protein -
OO832_RS05390 (1170193) 1170193..1170381 - 189 WP_000413705.1 cell division inhibition protein DicB -
OO832_RS05395 (1170955) 1170955..1171140 + 186 WP_001133046.1 hypothetical protein -
OO832_RS05400 (1171327) 1171327..1171716 - 390 WP_000394511.1 hypothetical protein -
OO832_RS05405 (1171728) 1171728..1171856 - 129 WP_000344963.1 protein YdfB -
OO832_RS05410 (1171858) 1171858..1172013 - 156 WP_000379575.1 DUF1391 family protein -
OO832_RS05415 (1172291) 1172291..1172578 - 288 WP_001303876.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OO832_RS05420 (1172578) 1172578..1172769 - 192 WP_000536233.1 hypothetical protein Antitoxin
OO832_RS05425 (1172797) 1172797..1173198 - 402 WP_264831048.1 helix-turn-helix domain-containing protein -
OO832_RS05430 (1173307) 1173307..1173579 + 273 WP_000887453.1 YdaS family helix-turn-helix protein -
OO832_RS05435 (1173563) 1173563..1173988 + 426 WP_000693855.1 toxin YdaT family protein -
OO832_RS05440 (1174195) 1174195..1174650 - 456 WP_000273724.1 hypothetical protein -
OO832_RS05445 (1174729) 1174729..1175820 + 1092 WP_001205823.1 hypothetical protein -
OO832_RS05450 (1175827) 1175827..1176573 + 747 WP_000788745.1 ATP-binding protein -
OO832_RS05455 (1176595) 1176595..1177365 + 771 WP_000450992.1 DUF1627 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10978.84 Da        Isoelectric Point: 10.1360

>T42065 WP_001303876.1 NZ_AP026097:c1172578-1172291 [Escherichia coli]
MLPILWLPSARDDLRQIITYIAKENPPAARRLKIRIETSVLPLSEHPYLYPPSERVSGLREIVTHPNYIILYRVAASSIE
IVSVTHSRRQFPFSI

Download         Length: 288 bp

>T42065 NZ_AP026097:c1172578-1172291 [Escherichia coli]
ATGTTACCCATTTTATGGCTACCGTCTGCTCGCGATGATTTGCGCCAGATCATAACTTACATCGCCAAGGAGAACCCACC
GGCAGCACGTAGACTAAAAATACGCATTGAAACATCGGTATTACCTCTATCTGAGCATCCGTACTTATATCCACCAAGCG
AACGGGTTTCTGGATTGAGAGAGATCGTGACCCACCCTAACTACATAATCCTGTACAGAGTAGCTGCTTCAAGCATTGAG
ATTGTAAGCGTGACACATTCTCGGCGACAATTTCCCTTCTCTATCTGA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7025.80 Da        Isoelectric Point: 4.0270

>AT42065 WP_000536233.1 NZ_AP026097:c1172769-1172578 [Escherichia coli]
MGTALSPIVSEFETTEQENSYNEWLRTKVTSSLADTRPAIPHDEVMAEMENLIAQIAVTNKSE

Download         Length: 192 bp

>AT42065 NZ_AP026097:c1172769-1172578 [Escherichia coli]
ATGGGTACAGCCCTTTCTCCGATAGTTTCAGAATTCGAAACTACCGAACAAGAAAACAGTTACAACGAATGGTTGCGCAC
TAAAGTAACGTCAAGCCTTGCAGACACTCGCCCCGCAATTCCACATGACGAGGTAATGGCTGAAATGGAAAATCTTATTG
CTCAAATTGCTGTAACTAACAAGAGCGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References