Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 4260929..4261560 Replicon chromosome
Accession NZ_AP026095
Organism Escherichia coli strain 53_142304

Toxin (Protein)


Gene name hicA Uniprot ID U9Y2A7
Locus tag OO816_RS21485 Protein ID WP_001259385.1
Coordinates 4261285..4261560 (-) Length 92 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID U9Y7E1
Locus tag OO816_RS21480 Protein ID WP_000593555.1
Coordinates 4260929..4261288 (-) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OO816_RS21450 (4256041) 4256041..4256514 + 474 WP_001161553.1 PTS sugar transporter subunit IIA -
OO816_RS21455 (4256511) 4256511..4256792 + 282 WP_000084025.1 PTS sugar transporter subunit IIB -
OO816_RS21460 (4256869) 4256869..4258227 + 1359 WP_001302220.1 PTS galactitol transporter subunit IIC -
OO816_RS21465 (4258220) 4258220..4259728 + 1509 WP_001301773.1 FGGY-family carbohydrate kinase -
OO816_RS21470 (4259718) 4259718..4259987 + 270 WP_000933060.1 HPr family phosphocarrier protein -
OO816_RS21475 (4260019) 4260019..4260879 + 861 WP_001131788.1 class II aldolase -
OO816_RS21480 (4260929) 4260929..4261288 - 360 WP_000593555.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
OO816_RS21485 (4261285) 4261285..4261560 - 276 WP_001259385.1 type II toxin-antitoxin system HicA family toxin Toxin
OO816_RS21490 (4261633) 4261633..4262757 - 1125 WP_001301659.1 ABC transporter permease -
OO816_RS21495 (4262757) 4262757..4265492 - 2736 WP_000149107.1 ribosome-associated ATPase/putative transporter RbbA -
OO816_RS21500 (4265489) 4265489..4266556 - 1068 WP_000361458.1 HlyD family secretion protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(30-80)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10199.94 Da        Isoelectric Point: 10.7076

>T42050 WP_001259385.1 NZ_AP026095:c4261560-4261285 [Escherichia coli]
MRTKVQALRKKQKNTLDQIFKTPVPQGIKWSDIESLVKALGGEIKEGRGSRCKFILNMSVACFHRPHPSPDTDKGAVESV
RDWLLSIGVKP

Download         Length: 276 bp

>T42050 NZ_AP026095:c4261560-4261285 [Escherichia coli]
ATGAGAACCAAGGTACAGGCTTTACGGAAGAAACAAAAAAATACATTGGATCAAATATTTAAAACTCCTGTTCCTCAAGG
GATCAAGTGGTCTGATATAGAGTCACTGGTTAAAGCATTAGGCGGAGAAATTAAGGAAGGAAGAGGTTCGCGTTGTAAGT
TCATACTAAATATGAGCGTTGCGTGTTTCCATCGGCCTCATCCGTCGCCAGATACCGATAAAGGCGCTGTAGAAAGCGTG
CGTGACTGGTTACTAAGTATAGGGGTAAAACCATGA

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13402.27 Da        Isoelectric Point: 5.1987

>AT42050 WP_000593555.1 NZ_AP026095:c4261288-4260929 [Escherichia coli]
MIKLKTPNSMEIAGQPAVITYVPELNAFRGKFLGLSGYCDFVSDSIQGLQKEGELSLREYLEDCKAAGIEPYARTEKIKT
FTLRYPESLSERLNNAAAQQQVSVNTYIIETLNERLNHL

Download         Length: 360 bp

>AT42050 NZ_AP026095:c4261288-4260929 [Escherichia coli]
ATGATCAAACTGAAGACGCCAAACTCTATGGAGATTGCCGGGCAACCTGCTGTTATCACTTACGTGCCAGAACTGAATGC
ATTTCGTGGCAAATTCCTGGGCTTGTCAGGTTATTGTGATTTTGTCTCTGACAGCATTCAGGGGCTGCAAAAAGAAGGGG
AACTTTCCCTGCGAGAGTATCTTGAGGATTGTAAAGCTGCGGGTATTGAGCCGTATGCGCGTACAGAAAAGATTAAGACC
TTTACGTTACGCTATCCAGAATCGCTGAGTGAACGCCTTAATAATGCGGCTGCGCAGCAACAAGTCTCTGTTAATACCTA
TATTATTGAAACACTGAATGAGCGTTTGAATCATTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4P7TTW8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LKZ6

References