Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 3432993..3433471 Replicon chromosome
Accession NZ_AP026095
Organism Escherichia coli strain 53_142304

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A891SFN9
Locus tag OO816_RS17520 Protein ID WP_001303876.1
Coordinates 3433184..3433471 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID Q8XD67
Locus tag OO816_RS17515 Protein ID WP_000536233.1
Coordinates 3432993..3433184 (+) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OO816_RS17480 (3428397) 3428397..3429167 - 771 WP_000450992.1 DUF1627 domain-containing protein -
OO816_RS17485 (3429189) 3429189..3429935 - 747 WP_000788745.1 ATP-binding protein -
OO816_RS17490 (3429942) 3429942..3431033 - 1092 WP_001205823.1 hypothetical protein -
OO816_RS17495 (3431112) 3431112..3431567 + 456 WP_000273724.1 hypothetical protein -
OO816_RS17500 (3431774) 3431774..3432199 - 426 WP_000693855.1 toxin YdaT family protein -
OO816_RS17505 (3432183) 3432183..3432455 - 273 WP_000887453.1 YdaS family helix-turn-helix protein -
OO816_RS17510 (3432564) 3432564..3432965 + 402 WP_000986592.1 helix-turn-helix domain-containing protein -
OO816_RS17515 (3432993) 3432993..3433184 + 192 WP_000536233.1 hypothetical protein Antitoxin
OO816_RS17520 (3433184) 3433184..3433471 + 288 WP_001303876.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OO816_RS17525 (3433749) 3433749..3433904 + 156 WP_000379575.1 DUF1391 family protein -
OO816_RS17530 (3433906) 3433906..3434034 + 129 WP_000344963.1 protein YdfB -
OO816_RS17535 (3434046) 3434046..3434435 + 390 WP_000394511.1 hypothetical protein -
OO816_RS17540 (3434622) 3434622..3434807 - 186 WP_001133046.1 hypothetical protein -
OO816_RS17545 (3435381) 3435381..3435569 + 189 WP_000413705.1 cell division inhibition protein DicB -
OO816_RS17550 (3435566) 3435566..3435757 + 192 WP_001098307.1 DUF1482 family protein -
OO816_RS17555 (3435851) 3435851..3438322 + 2472 WP_000034474.1 exonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10978.84 Da        Isoelectric Point: 10.1360

>T42046 WP_001303876.1 NZ_AP026095:3433184-3433471 [Escherichia coli]
MLPILWLPSARDDLRQIITYIAKENPPAARRLKIRIETSVLPLSEHPYLYPPSERVSGLREIVTHPNYIILYRVAASSIE
IVSVTHSRRQFPFSI

Download         Length: 288 bp

>T42046 NZ_AP026095:3433184-3433471 [Escherichia coli]
ATGTTACCCATTTTATGGCTACCGTCTGCTCGCGATGATTTGCGCCAGATCATAACTTACATCGCCAAGGAGAACCCACC
GGCAGCACGTAGACTAAAAATACGCATTGAAACATCGGTATTACCTCTATCTGAGCATCCGTACTTATATCCACCAAGCG
AACGGGTTTCTGGATTGAGAGAGATCGTGACCCACCCTAACTACATAATCCTGTACAGAGTAGCTGCTTCAAGCATTGAG
ATTGTAAGCGTGACACATTCTCGGCGACAATTTCCCTTCTCTATCTGA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7025.80 Da        Isoelectric Point: 4.0270

>AT42046 WP_000536233.1 NZ_AP026095:3432993-3433184 [Escherichia coli]
MGTALSPIVSEFETTEQENSYNEWLRTKVTSSLADTRPAIPHDEVMAEMENLIAQIAVTNKSE

Download         Length: 192 bp

>AT42046 NZ_AP026095:3432993-3433184 [Escherichia coli]
ATGGGTACAGCCCTTTCTCCGATAGTTTCAGAATTCGAAACTACCGAACAAGAAAACAGTTACAACGAATGGTTGCGCAC
TAAAGTAACGTCAAGCCTTGCAGACACTCGCCCCGCAATTCCACATGACGAGGTAATGGCTGAAATGGAAAATCTTATTG
CTCAAATTGCTGTAACTAACAAGAGCGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References