Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | paaR-paaA-parE/- |
| Location | 2570093..2570564 | Replicon | chromosome |
| Accession | NZ_AP026095 | ||
| Organism | Escherichia coli strain 53_142304 | ||
Toxin (Protein)
| Gene name | parE_1 | Uniprot ID | A0A0D7C2L1 |
| Locus tag | OO816_RS12980 | Protein ID | WP_001303511.1 |
| Coordinates | 2570093..2570371 (-) | Length | 93 a.a. |
Antitoxin (Protein)
| Gene name | paaA | Uniprot ID | Q8XAD5 |
| Locus tag | OO816_RS12985 | Protein ID | WP_001302048.1 |
| Coordinates | 2570373..2570564 (-) | Length | 64 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| OO816_RS12955 (2567029) | 2567029..2568114 | - | 1086 | Protein_2538 | exonuclease | - |
| OO816_RS12960 (2568207) | 2568207..2568398 | - | 192 | WP_001090200.1 | DUF1482 family protein | - |
| OO816_RS12965 (2568395) | 2568395..2568583 | - | 189 | WP_000449192.1 | cell division inhibition protein DicB | - |
| OO816_RS12970 (2569152) | 2569152..2569370 | - | 219 | WP_001171930.1 | protein YdfC | - |
| OO816_RS12975 (2569442) | 2569442..2569741 | - | 300 | WP_001240334.1 | hypothetical protein | - |
| OO816_RS12980 (2570093) | 2570093..2570371 | - | 279 | WP_001303511.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| OO816_RS12985 (2570373) | 2570373..2570564 | - | 192 | WP_001302048.1 | hypothetical protein | Antitoxin |
| OO816_RS12990 (2570585) | 2570585..2570956 | - | 372 | WP_001169686.1 | hypothetical protein | - |
| OO816_RS12995 (2571054) | 2571054..2571356 | + | 303 | WP_000172738.1 | transcriptional regulator | - |
| OO816_RS13000 (2571353) | 2571353..2571778 | + | 426 | WP_000693943.1 | toxin YdaT family protein | - |
| OO816_RS13005 (2571801) | 2571801..2572763 | + | 963 | WP_000095669.1 | helix-turn-helix domain-containing protein | - |
| OO816_RS13010 (2572770) | 2572770..2573510 | + | 741 | WP_000788939.1 | ATP-binding protein | - |
| OO816_RS13015 (2573536) | 2573536..2574305 | + | 770 | Protein_2550 | DUF1627 domain-containing protein | - |
| OO816_RS13020 (2574321) | 2574321..2574716 | + | 396 | WP_001118159.1 | DUF977 family protein | - |
| OO816_RS13025 (2574773) | 2574773..2575357 | + | 585 | WP_000206793.1 | DUF551 domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 2561620..2618946 | 57326 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 93 a.a. Molecular weight: 10661.25 Da Isoelectric Point: 5.5647
>T42043 WP_001303511.1 NZ_AP026095:c2570371-2570093 [Escherichia coli]
MLPVLWLESADTDLDDITSYIARFDIDAAERLWQRLRGCVLPLSEHPYLYPPSDRVPGLREIVAHPNYIILYRVTTSSVE
VVNVIHARRQFP
MLPVLWLESADTDLDDITSYIARFDIDAAERLWQRLRGCVLPLSEHPYLYPPSDRVPGLREIVAHPNYIILYRVTTSSVE
VVNVIHARRQFP
Download Length: 279 bp
>T42043 NZ_AP026095:c2570371-2570093 [Escherichia coli]
ATGTTACCCGTGTTATGGCTTGAAAGCGCAGATACCGACCTAGATGATATAACTAGTTATATTGCTCGTTTCGACATAGA
TGCGGCTGAACGCTTATGGCAGCGATTAAGGGGTTGTGTGCTGCCGTTATCCGAACATCCGTATTTATACCCACCAAGCG
ACAGAGTACCTGGCTTGCGTGAGATTGTAGCCCACCCTAACTATATAATTCTATACCGCGTAACAACATCAAGCGTTGAA
GTAGTAAACGTGATCCACGCAAGACGCCAGTTTCCCTAA
ATGTTACCCGTGTTATGGCTTGAAAGCGCAGATACCGACCTAGATGATATAACTAGTTATATTGCTCGTTTCGACATAGA
TGCGGCTGAACGCTTATGGCAGCGATTAAGGGGTTGTGTGCTGCCGTTATCCGAACATCCGTATTTATACCCACCAAGCG
ACAGAGTACCTGGCTTGCGTGAGATTGTAGCCCACCCTAACTATATAATTCTATACCGCGTAACAACATCAAGCGTTGAA
GTAGTAAACGTGATCCACGCAAGACGCCAGTTTCCCTAA
Antitoxin
Download Length: 64 a.a. Molecular weight: 7463.47 Da Isoelectric Point: 8.6828
>AT42043 WP_001302048.1 NZ_AP026095:c2570564-2570373 [Escherichia coli]
MNRALSPMVSEFETIEQENSYNEWLRAKVATSLADPRPAIPHDEVERRMAERFAKMRKERSKQ
MNRALSPMVSEFETIEQENSYNEWLRAKVATSLADPRPAIPHDEVERRMAERFAKMRKERSKQ
Download Length: 192 bp
>AT42043 NZ_AP026095:c2570564-2570373 [Escherichia coli]
ATGAATAGAGCCCTTTCACCAATGGTTTCTGAATTTGAAACCATTGAACAAGAAAACAGTTACAACGAATGGCTGCGTGC
GAAAGTAGCAACGAGCCTTGCAGATCCGCGCCCAGCAATTCCCCATGACGAAGTTGAGCGCAGAATGGCAGAACGCTTTG
CTAAGATGCGCAAGGAACGGAGCAAGCAGTAA
ATGAATAGAGCCCTTTCACCAATGGTTTCTGAATTTGAAACCATTGAACAAGAAAACAGTTACAACGAATGGCTGCGTGC
GAAAGTAGCAACGAGCCTTGCAGATCCGCGCCCAGCAATTCCCCATGACGAAGTTGAGCGCAGAATGGCAGAACGCTTTG
CTAAGATGCGCAAGGAACGGAGCAAGCAGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|