Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 1880307..1880945 Replicon chromosome
Accession NZ_AP026092
Organism Escherichia coli strain 27_141091

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag OO959_RS09275 Protein ID WP_000813794.1
Coordinates 1880307..1880483 (+) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag OO959_RS09280 Protein ID WP_001270286.1
Coordinates 1880529..1880945 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OO959_RS09255 (1875928) 1875928..1877101 - 1174 Protein_1816 BenE family transporter YdcO -
OO959_RS09260 (1877193) 1877193..1877729 + 537 WP_000429145.1 DNA-binding transcriptional regulator SutR -
OO959_RS09265 (1877802) 1877802..1879763 + 1962 WP_001303492.1 23S rRNA 5-hydroxycytidine C2501 synthase -
OO959_RS09270 (1879855) 1879855..1880085 - 231 WP_000494244.1 YncJ family protein -
OO959_RS09275 (1880307) 1880307..1880483 + 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
OO959_RS09280 (1880529) 1880529..1880945 + 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
OO959_RS09285 (1881024) 1881024..1882430 + 1407 WP_000760654.1 PLP-dependent aminotransferase family protein -
OO959_RS09290 (1882675) 1882675..1883820 + 1146 WP_000047432.1 ABC transporter substrate-binding protein -
OO959_RS09295 (1883838) 1883838..1884851 + 1014 WP_000220402.1 ABC transporter ATP-binding protein -
OO959_RS09300 (1884852) 1884852..1885793 + 942 WP_001251315.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T42005 WP_000813794.1 NZ_AP026092:1880307-1880483 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

>T42005 NZ_AP026092:1880307-1880483 [Escherichia coli]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTGAAACTCAG
GTTTCATGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT42005 WP_001270286.1 NZ_AP026092:1880529-1880945 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp

>AT42005 NZ_AP026092:1880529-1880945 [Escherichia coli]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
GCAGGGCGAAACTGTCGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCTTTACCTTCGCCATTAAATAGTCATGATCACTTTATTGAAGTACCTTTGAGCGTCGCCTCTAAGGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAAGAGAT
TACTCGCCTATTTAACTTGCATCATGCGACAAAAATCGACGCCGTCCAGCTCGCGGCAAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References