Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | paaR-paaA-parE/- |
| Location | 1669884..1670355 | Replicon | chromosome |
| Accession | NZ_AP026092 | ||
| Organism | Escherichia coli strain 27_141091 | ||
Toxin (Protein)
| Gene name | parE_1 | Uniprot ID | A0A0D7C2L1 |
| Locus tag | OO959_RS08165 | Protein ID | WP_001303511.1 |
| Coordinates | 1669884..1670162 (-) | Length | 93 a.a. |
Antitoxin (Protein)
| Gene name | paaA | Uniprot ID | Q8XAD5 |
| Locus tag | OO959_RS08170 | Protein ID | WP_001302048.1 |
| Coordinates | 1670164..1670355 (-) | Length | 64 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| OO959_RS08140 (1666820) | 1666820..1667905 | - | 1086 | Protein_1596 | exonuclease | - |
| OO959_RS08145 (1667998) | 1667998..1668189 | - | 192 | WP_001090200.1 | DUF1482 family protein | - |
| OO959_RS08150 (1668186) | 1668186..1668374 | - | 189 | WP_000449192.1 | cell division inhibition protein DicB | - |
| OO959_RS08155 (1668943) | 1668943..1669161 | - | 219 | WP_001171930.1 | protein YdfC | - |
| OO959_RS08160 (1669233) | 1669233..1669532 | - | 300 | WP_001240334.1 | hypothetical protein | - |
| OO959_RS08165 (1669884) | 1669884..1670162 | - | 279 | WP_001303511.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| OO959_RS08170 (1670164) | 1670164..1670355 | - | 192 | WP_001302048.1 | hypothetical protein | Antitoxin |
| OO959_RS08175 (1670376) | 1670376..1670747 | - | 372 | WP_001169686.1 | hypothetical protein | - |
| OO959_RS08180 (1670845) | 1670845..1671147 | + | 303 | WP_000172738.1 | transcriptional regulator | - |
| OO959_RS08185 (1671144) | 1671144..1671569 | + | 426 | WP_000693943.1 | toxin YdaT family protein | - |
| OO959_RS08190 (1671592) | 1671592..1672554 | + | 963 | WP_000095669.1 | helix-turn-helix domain-containing protein | - |
| OO959_RS08195 (1672561) | 1672561..1673301 | + | 741 | WP_000788938.1 | ATP-binding protein | - |
| OO959_RS08200 (1673327) | 1673327..1674096 | + | 770 | Protein_1608 | DUF1627 domain-containing protein | - |
| OO959_RS08205 (1674112) | 1674112..1674507 | + | 396 | WP_001118159.1 | DUF977 family protein | - |
| OO959_RS08210 (1674564) | 1674564..1675148 | + | 585 | WP_000206793.1 | DUF551 domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | nleA/espI | 1661411..1712042 | 50631 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 93 a.a. Molecular weight: 10661.25 Da Isoelectric Point: 5.5647
>T42004 WP_001303511.1 NZ_AP026092:c1670162-1669884 [Escherichia coli]
MLPVLWLESADTDLDDITSYIARFDIDAAERLWQRLRGCVLPLSEHPYLYPPSDRVPGLREIVAHPNYIILYRVTTSSVE
VVNVIHARRQFP
MLPVLWLESADTDLDDITSYIARFDIDAAERLWQRLRGCVLPLSEHPYLYPPSDRVPGLREIVAHPNYIILYRVTTSSVE
VVNVIHARRQFP
Download Length: 279 bp
>T42004 NZ_AP026092:c1670162-1669884 [Escherichia coli]
ATGTTACCCGTGTTATGGCTTGAAAGCGCAGATACCGACCTAGATGATATAACTAGTTATATTGCTCGTTTCGACATAGA
TGCGGCTGAACGCTTATGGCAGCGATTAAGGGGTTGTGTGCTGCCGTTATCCGAACATCCGTATTTATACCCACCAAGCG
ACAGAGTACCTGGCTTGCGTGAGATTGTAGCCCACCCTAACTATATAATTCTATACCGCGTAACAACATCAAGCGTTGAA
GTAGTAAACGTGATCCACGCAAGACGCCAGTTTCCCTAA
ATGTTACCCGTGTTATGGCTTGAAAGCGCAGATACCGACCTAGATGATATAACTAGTTATATTGCTCGTTTCGACATAGA
TGCGGCTGAACGCTTATGGCAGCGATTAAGGGGTTGTGTGCTGCCGTTATCCGAACATCCGTATTTATACCCACCAAGCG
ACAGAGTACCTGGCTTGCGTGAGATTGTAGCCCACCCTAACTATATAATTCTATACCGCGTAACAACATCAAGCGTTGAA
GTAGTAAACGTGATCCACGCAAGACGCCAGTTTCCCTAA
Antitoxin
Download Length: 64 a.a. Molecular weight: 7463.47 Da Isoelectric Point: 8.6828
>AT42004 WP_001302048.1 NZ_AP026092:c1670355-1670164 [Escherichia coli]
MNRALSPMVSEFETIEQENSYNEWLRAKVATSLADPRPAIPHDEVERRMAERFAKMRKERSKQ
MNRALSPMVSEFETIEQENSYNEWLRAKVATSLADPRPAIPHDEVERRMAERFAKMRKERSKQ
Download Length: 192 bp
>AT42004 NZ_AP026092:c1670355-1670164 [Escherichia coli]
ATGAATAGAGCCCTTTCACCAATGGTTTCTGAATTTGAAACCATTGAACAAGAAAACAGTTACAACGAATGGCTGCGTGC
GAAAGTAGCAACGAGCCTTGCAGATCCGCGCCCAGCAATTCCCCATGACGAAGTTGAGCGCAGAATGGCAGAACGCTTTG
CTAAGATGCGCAAGGAACGGAGCAAGCAGTAA
ATGAATAGAGCCCTTTCACCAATGGTTTCTGAATTTGAAACCATTGAACAAGAAAACAGTTACAACGAATGGCTGCGTGC
GAAAGTAGCAACGAGCCTTGCAGATCCGCGCCCAGCAATTCCCCATGACGAAGTTGAGCGCAGAATGGCAGAACGCTTTG
CTAAGATGCGCAAGGAACGGAGCAAGCAGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|