Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 1171501..1171979 Replicon chromosome
Accession NZ_AP026092
Organism Escherichia coli strain 27_141091

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A891SFN9
Locus tag OO959_RS05430 Protein ID WP_001303876.1
Coordinates 1171501..1171788 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID Q8XD67
Locus tag OO959_RS05435 Protein ID WP_000536233.1
Coordinates 1171788..1171979 (-) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OO959_RS05395 (1166650) 1166650..1169121 - 2472 WP_000034474.1 exonuclease -
OO959_RS05400 (1169215) 1169215..1169406 - 192 WP_001098307.1 DUF1482 family protein -
OO959_RS05405 (1169403) 1169403..1169591 - 189 WP_000413705.1 cell division inhibition protein DicB -
OO959_RS05410 (1170165) 1170165..1170350 + 186 WP_001133046.1 hypothetical protein -
OO959_RS05415 (1170537) 1170537..1170926 - 390 WP_000394511.1 hypothetical protein -
OO959_RS05420 (1170938) 1170938..1171066 - 129 WP_000344963.1 protein YdfB -
OO959_RS05425 (1171068) 1171068..1171223 - 156 WP_000379575.1 DUF1391 family protein -
OO959_RS05430 (1171501) 1171501..1171788 - 288 WP_001303876.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OO959_RS05435 (1171788) 1171788..1171979 - 192 WP_000536233.1 hypothetical protein Antitoxin
OO959_RS05440 (1172007) 1172007..1172408 - 402 WP_000986592.1 helix-turn-helix domain-containing protein -
OO959_RS05445 (1172517) 1172517..1172789 + 273 WP_000887453.1 YdaS family helix-turn-helix protein -
OO959_RS05450 (1172773) 1172773..1173198 + 426 WP_000693855.1 toxin YdaT family protein -
OO959_RS05455 (1173405) 1173405..1173860 - 456 WP_000273724.1 hypothetical protein -
OO959_RS05460 (1173939) 1173939..1175030 + 1092 WP_001205823.1 hypothetical protein -
OO959_RS05465 (1175037) 1175037..1175783 + 747 WP_000788745.1 ATP-binding protein -
OO959_RS05470 (1175805) 1175805..1176575 + 771 WP_000450992.1 DUF1627 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10978.84 Da        Isoelectric Point: 10.1360

>T41991 WP_001303876.1 NZ_AP026092:c1171788-1171501 [Escherichia coli]
MLPILWLPSARDDLRQIITYIAKENPPAARRLKIRIETSVLPLSEHPYLYPPSERVSGLREIVTHPNYIILYRVAASSIE
IVSVTHSRRQFPFSI

Download         Length: 288 bp

>T41991 NZ_AP026092:c1171788-1171501 [Escherichia coli]
ATGTTACCCATTTTATGGCTACCGTCTGCTCGCGATGATTTGCGCCAGATCATAACTTACATCGCCAAGGAGAACCCACC
GGCAGCACGTAGACTAAAAATACGCATTGAAACATCGGTATTACCTCTATCTGAGCATCCGTACTTATATCCACCAAGCG
AACGGGTTTCTGGATTGAGAGAGATCGTGACCCACCCTAACTACATAATCCTGTACAGAGTAGCTGCTTCAAGCATTGAG
ATTGTAAGCGTGACACATTCTCGGCGACAATTTCCCTTCTCTATCTGA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7025.80 Da        Isoelectric Point: 4.0270

>AT41991 WP_000536233.1 NZ_AP026092:c1171979-1171788 [Escherichia coli]
MGTALSPIVSEFETTEQENSYNEWLRTKVTSSLADTRPAIPHDEVMAEMENLIAQIAVTNKSE

Download         Length: 192 bp

>AT41991 NZ_AP026092:c1171979-1171788 [Escherichia coli]
ATGGGTACAGCCCTTTCTCCGATAGTTTCAGAATTCGAAACTACCGAACAAGAAAACAGTTACAACGAATGGTTGCGCAC
TAAAGTAACGTCAAGCCTTGCAGACACTCGCCCCGCAATTCCACATGACGAGGTAATGGCTGAAATGGAAAATCTTATTG
CTCAAATTGCTGTAACTAACAAGAGCGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References