Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 5237599..5238194 Replicon chromosome
Accession NZ_AP026090
Organism Escherichia coli strain 26_141088

Toxin (Protein)


Gene name chpB Uniprot ID U9Y4M4
Locus tag OO788_RS26235 Protein ID WP_000239579.1
Coordinates 5237844..5238194 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID Q8XCF3
Locus tag OO788_RS26230 Protein ID WP_001223210.1
Coordinates 5237599..5237850 (+) Length 84 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OO788_RS26220 (5233264) 5233264..5237043 + 3780 WP_000060930.1 autotransporter assembly complex protein TamB -
OO788_RS26225 (5237046) 5237046..5237387 + 342 WP_001219160.1 gamma-glutamylcyclotransferase -
OO788_RS26230 (5237599) 5237599..5237850 + 252 WP_001223210.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
OO788_RS26235 (5237844) 5237844..5238194 + 351 WP_000239579.1 endoribonuclease toxin ChpB Toxin
OO788_RS26240 (5238274) 5238274..5238804 - 531 WP_000055075.1 inorganic diphosphatase -
OO788_RS26245 (5239114) 5239114..5240070 + 957 WP_000265942.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
OO788_RS26250 (5240210) 5240210..5241712 + 1503 Protein_5129 sugar ABC transporter ATP-binding protein -
OO788_RS26255 (5241726) 5241726..5242748 + 1023 WP_001301928.1 ABC transporter permease -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(8-114)

Antitoxin

(6-49)


Sequences


Toxin        


Download         Length: 117 a.a.        Molecular weight: 12511.45 Da        Isoelectric Point: 5.6219

>T41981 WP_000239579.1 NZ_AP026090:5237844-5238194 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

>T41981 NZ_AP026090:5237844-5238194 [Escherichia coli]
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GTGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTT
AATCAGGTGCGGATGATGGATCTACGCGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGATGAGGTGGTGGAAGAGGC
GTTATTACGCTTGCAGGCGGTGGTGGAATAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9299.64 Da        Isoelectric Point: 4.4201

>AT41981 WP_001223210.1 NZ_AP026090:5237599-5237850 [Escherichia coli]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEVQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp

>AT41981 NZ_AP026090:5237599-5237850 [Escherichia coli]
ATGCGTATTACCATAAAAAGATGGGGGAACAGTGCAGGTATGGTCATTCCCAATATCGTAATGAAAGAACTTAACTTACA
GCCGGGGCAGAGCGTGGAAGTGCAGGTGAGCAACAACCAACTGATTCTGACACCCATCTCCAGGCGCTACTCGCTTGATG
AACTGCTGGCACAGTGTGACATGAACGCCGCGGAACTTAGCGAGCAGGATGTCTGGGGTAAATCCACCCCTGCGGGTGAC
GAAATATGGTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A0E0Y8A8


Antitoxin

Source ID Structure

References