Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 2107459..2107930 Replicon chromosome
Accession NZ_AP026090
Organism Escherichia coli strain 26_141088

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A0D7C2L1
Locus tag OO788_RS10555 Protein ID WP_001303511.1
Coordinates 2107652..2107930 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID Q8XAD5
Locus tag OO788_RS10550 Protein ID WP_001302048.1
Coordinates 2107459..2107650 (+) Length 64 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OO788_RS10510 (2102666) 2102666..2103250 - 585 WP_000206793.1 DUF551 domain-containing protein -
OO788_RS10515 (2103307) 2103307..2103702 - 396 WP_001118159.1 DUF977 family protein -
OO788_RS10520 (2103718) 2103718..2104487 - 770 Protein_2064 DUF1627 domain-containing protein -
OO788_RS10525 (2104513) 2104513..2105253 - 741 WP_000788938.1 ATP-binding protein -
OO788_RS10530 (2105260) 2105260..2106222 - 963 WP_000095669.1 helix-turn-helix domain-containing protein -
OO788_RS10535 (2106245) 2106245..2106670 - 426 WP_000693943.1 toxin YdaT family protein -
OO788_RS10540 (2106667) 2106667..2106969 - 303 WP_000172738.1 transcriptional regulator -
OO788_RS10545 (2107067) 2107067..2107438 + 372 WP_001169686.1 hypothetical protein -
OO788_RS10550 (2107459) 2107459..2107650 + 192 WP_001302048.1 hypothetical protein Antitoxin
OO788_RS10555 (2107652) 2107652..2107930 + 279 WP_001303511.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OO788_RS10560 (2108283) 2108283..2108582 + 300 WP_001240334.1 hypothetical protein -
OO788_RS10565 (2108654) 2108654..2108872 + 219 WP_001171930.1 protein YdfC -
OO788_RS10570 (2109441) 2109441..2109629 + 189 WP_000449192.1 cell division inhibition protein DicB -
OO788_RS10575 (2109626) 2109626..2109817 + 192 WP_001090200.1 DUF1482 family protein -
OO788_RS10580 (2109910) 2109910..2110995 + 1086 Protein_2076 exonuclease -
OO788_RS10585 (2111046) 2111046..2112259 + 1214 WP_162829202.1 IS3-like element IS1203 family transposase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - nleG7' 2022429..2124123 101694


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(4-91)

Antitoxin


No domain identified.



Sequences


Toxin        


Download         Length: 93 a.a.        Molecular weight: 10661.25 Da        Isoelectric Point: 5.5647

>T41962 WP_001303511.1 NZ_AP026090:2107652-2107930 [Escherichia coli]
MLPVLWLESADTDLDDITSYIARFDIDAAERLWQRLRGCVLPLSEHPYLYPPSDRVPGLREIVAHPNYIILYRVTTSSVE
VVNVIHARRQFP

Download         Length: 279 bp

>T41962 NZ_AP026090:2107652-2107930 [Escherichia coli]
ATGTTACCCGTGTTATGGCTTGAAAGCGCAGATACCGACCTAGATGATATAACTAGTTATATTGCTCGTTTCGACATAGA
TGCGGCTGAACGCTTATGGCAGCGATTAAGGGGTTGTGTGCTGCCGTTATCCGAACATCCGTATTTATACCCACCAAGCG
ACAGAGTACCTGGCTTGCGTGAGATTGTAGCCCACCCTAACTATATAATTCTATACCGCGTAACAACATCAAGCGTTGAA
GTAGTAAACGTGATCCACGCAAGACGCCAGTTTCCCTAA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7463.47 Da        Isoelectric Point: 8.6828

>AT41962 WP_001302048.1 NZ_AP026090:2107459-2107650 [Escherichia coli]
MNRALSPMVSEFETIEQENSYNEWLRAKVATSLADPRPAIPHDEVERRMAERFAKMRKERSKQ

Download         Length: 192 bp

>AT41962 NZ_AP026090:2107459-2107650 [Escherichia coli]
ATGAATAGAGCCCTTTCACCAATGGTTTCTGAATTTGAAACCATTGAACAAGAAAACAGTTACAACGAATGGCTGCGTGC
GAAAGTAGCAACGAGCCTTGCAGATCCGCGCCCAGCAATTCCCCATGACGAAGTTGAGCGCAGAATGGCAGAACGCTTTG
CTAAGATGCGCAAGGAACGGAGCAAGCAGTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
PDB 5CZF
PDB 5CW7
PDB 5CZE


Antitoxin

Source ID Structure
PDB 5CZF
PDB 3ZBE
PDB 5CW7
AlphaFold DB A0A829CTP0

References