Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 1890570..1891208 Replicon chromosome
Accession NZ_AP026090
Organism Escherichia coli strain 26_141088

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag OO788_RS09380 Protein ID WP_000813794.1
Coordinates 1890570..1890746 (+) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag OO788_RS09385 Protein ID WP_001270286.1
Coordinates 1890792..1891208 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OO788_RS09360 (1886191) 1886191..1887364 - 1174 Protein_1838 BenE family transporter YdcO -
OO788_RS09365 (1887456) 1887456..1887992 + 537 WP_000429145.1 DNA-binding transcriptional regulator SutR -
OO788_RS09370 (1888065) 1888065..1890026 + 1962 WP_001303492.1 23S rRNA 5-hydroxycytidine C2501 synthase -
OO788_RS09375 (1890118) 1890118..1890348 - 231 WP_000494244.1 YncJ family protein -
OO788_RS09380 (1890570) 1890570..1890746 + 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
OO788_RS09385 (1890792) 1890792..1891208 + 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
OO788_RS09390 (1891287) 1891287..1892693 + 1407 WP_000760654.1 PLP-dependent aminotransferase family protein -
OO788_RS09395 (1892938) 1892938..1894083 + 1146 WP_000047432.1 ABC transporter substrate-binding protein -
OO788_RS09400 (1894101) 1894101..1895114 + 1014 WP_000220402.1 ABC transporter ATP-binding protein -
OO788_RS09405 (1895115) 1895115..1896056 + 942 WP_001251315.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T41959 WP_000813794.1 NZ_AP026090:1890570-1890746 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

>T41959 NZ_AP026090:1890570-1890746 [Escherichia coli]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTGAAACTCAG
GTTTCATGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT41959 WP_001270286.1 NZ_AP026090:1890792-1891208 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp

>AT41959 NZ_AP026090:1890792-1891208 [Escherichia coli]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
GCAGGGCGAAACTGTCGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCTTTACCTTCGCCATTAAATAGTCATGATCACTTTATTGAAGTACCTTTGAGCGTCGCCTCTAAGGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAAGAGAT
TACTCGCCTATTTAACTTGCATCATGCGACAAAAATCGACGCCGTCCAGCTCGCGGCAAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References