Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 1169800..1170278 Replicon chromosome
Accession NZ_AP026090
Organism Escherichia coli strain 26_141088

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A891SFN9
Locus tag OO788_RS05400 Protein ID WP_001303876.1
Coordinates 1169800..1170087 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID Q8XD67
Locus tag OO788_RS05405 Protein ID WP_000536233.1
Coordinates 1170087..1170278 (-) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OO788_RS05365 (1164949) 1164949..1167420 - 2472 WP_000034474.1 exonuclease -
OO788_RS05370 (1167514) 1167514..1167705 - 192 WP_001098307.1 DUF1482 family protein -
OO788_RS05375 (1167702) 1167702..1167890 - 189 WP_000413705.1 cell division inhibition protein DicB -
OO788_RS05380 (1168464) 1168464..1168649 + 186 WP_001133046.1 hypothetical protein -
OO788_RS05385 (1168836) 1168836..1169225 - 390 WP_000394511.1 hypothetical protein -
OO788_RS05390 (1169237) 1169237..1169365 - 129 WP_000344963.1 protein YdfB -
OO788_RS05395 (1169367) 1169367..1169522 - 156 WP_000379575.1 DUF1391 family protein -
OO788_RS05400 (1169800) 1169800..1170087 - 288 WP_001303876.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OO788_RS05405 (1170087) 1170087..1170278 - 192 WP_000536233.1 hypothetical protein Antitoxin
OO788_RS05410 (1170306) 1170306..1170707 - 402 WP_000986592.1 helix-turn-helix domain-containing protein -
OO788_RS05415 (1170816) 1170816..1171088 + 273 WP_000887453.1 YdaS family helix-turn-helix protein -
OO788_RS05420 (1171072) 1171072..1171497 + 426 WP_000693855.1 toxin YdaT family protein -
OO788_RS05425 (1171704) 1171704..1172159 - 456 WP_000273724.1 hypothetical protein -
OO788_RS05430 (1172238) 1172238..1173329 + 1092 WP_001205823.1 hypothetical protein -
OO788_RS05435 (1173336) 1173336..1174082 + 747 WP_000788745.1 ATP-binding protein -
OO788_RS05440 (1174104) 1174104..1174874 + 771 WP_000450992.1 DUF1627 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10978.84 Da        Isoelectric Point: 10.1360

>T41953 WP_001303876.1 NZ_AP026090:c1170087-1169800 [Escherichia coli]
MLPILWLPSARDDLRQIITYIAKENPPAARRLKIRIETSVLPLSEHPYLYPPSERVSGLREIVTHPNYIILYRVAASSIE
IVSVTHSRRQFPFSI

Download         Length: 288 bp

>T41953 NZ_AP026090:c1170087-1169800 [Escherichia coli]
ATGTTACCCATTTTATGGCTACCGTCTGCTCGCGATGATTTGCGCCAGATCATAACTTACATCGCCAAGGAGAACCCACC
GGCAGCACGTAGACTAAAAATACGCATTGAAACATCGGTATTACCTCTATCTGAGCATCCGTACTTATATCCACCAAGCG
AACGGGTTTCTGGATTGAGAGAGATCGTGACCCACCCTAACTACATAATCCTGTACAGAGTAGCTGCTTCAAGCATTGAG
ATTGTAAGCGTGACACATTCTCGGCGACAATTTCCCTTCTCTATCTGA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7025.80 Da        Isoelectric Point: 4.0270

>AT41953 WP_000536233.1 NZ_AP026090:c1170278-1170087 [Escherichia coli]
MGTALSPIVSEFETTEQENSYNEWLRTKVTSSLADTRPAIPHDEVMAEMENLIAQIAVTNKSE

Download         Length: 192 bp

>AT41953 NZ_AP026090:c1170278-1170087 [Escherichia coli]
ATGGGTACAGCCCTTTCTCCGATAGTTTCAGAATTCGAAACTACCGAACAAGAAAACAGTTACAACGAATGGTTGCGCAC
TAAAGTAACGTCAAGCCTTGCAGACACTCGCCCCGCAATTCCACATGACGAGGTAATGGCTGAAATGGAAAATCTTATTG
CTCAAATTGCTGTAACTAACAAGAGCGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References