Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 548707..549325 Replicon chromosome
Accession NZ_AP026090
Organism Escherichia coli strain 26_141088

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag OO788_RS02560 Protein ID WP_001291435.1
Coordinates 548707..548925 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag OO788_RS02565 Protein ID WP_000344800.1
Coordinates 548951..549325 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OO788_RS02525 (543994) 543994..544566 + 573 WP_000779831.1 YbaY family lipoprotein -
OO788_RS02530 (544599) 544599..544910 - 312 WP_000409911.1 MGMT family protein -
OO788_RS02540 (545289) 545289..545642 + 354 WP_000878140.1 DUF1428 domain-containing protein -
OO788_RS02545 (545684) 545684..547234 - 1551 WP_001301851.1 cyclic-guanylate-specific phosphodiesterase PdeB -
OO788_RS02550 (547398) 547398..547868 - 471 WP_000136192.1 YlaC family protein -
OO788_RS02555 (547984) 547984..548535 - 552 WP_000102553.1 maltose O-acetyltransferase -
OO788_RS02560 (548707) 548707..548925 - 219 WP_001291435.1 HHA domain-containing protein Toxin
OO788_RS02565 (548951) 548951..549325 - 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
OO788_RS02570 (549871) 549871..553020 - 3150 WP_001132452.1 efflux RND transporter permease AcrB -
OO788_RS02575 (553043) 553043..554236 - 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T41951 WP_001291435.1 NZ_AP026090:c548925-548707 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T41951 NZ_AP026090:c548925-548707 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT41951 WP_000344800.1 NZ_AP026090:c549325-548951 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp

>AT41951 NZ_AP026090:c549325-548951 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACTCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References