Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 1899251..1899889 Replicon chromosome
Accession NZ_AP026087
Organism Escherichia coli strain 8_140198

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag OO841_RS09500 Protein ID WP_000813794.1
Coordinates 1899251..1899427 (+) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag OO841_RS09505 Protein ID WP_001270286.1
Coordinates 1899473..1899889 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OO841_RS09480 (1894872) 1894872..1896045 - 1174 Protein_1858 BenE family transporter YdcO -
OO841_RS09485 (1896137) 1896137..1896673 + 537 WP_000429145.1 DNA-binding transcriptional regulator SutR -
OO841_RS09490 (1896746) 1896746..1898707 + 1962 WP_001303492.1 23S rRNA 5-hydroxycytidine C2501 synthase -
OO841_RS09495 (1898799) 1898799..1899029 - 231 WP_000494244.1 YncJ family protein -
OO841_RS09500 (1899251) 1899251..1899427 + 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
OO841_RS09505 (1899473) 1899473..1899889 + 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
OO841_RS09510 (1899968) 1899968..1901374 + 1407 WP_000760654.1 PLP-dependent aminotransferase family protein -
OO841_RS09515 (1901619) 1901619..1902764 + 1146 WP_000047432.1 ABC transporter substrate-binding protein -
OO841_RS09520 (1902782) 1902782..1903795 + 1014 WP_000220402.1 ABC transporter ATP-binding protein -
OO841_RS09525 (1903796) 1903796..1904737 + 942 WP_001251315.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T41920 WP_000813794.1 NZ_AP026087:1899251-1899427 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

>T41920 NZ_AP026087:1899251-1899427 [Escherichia coli]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTGAAACTCAG
GTTTCATGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT41920 WP_001270286.1 NZ_AP026087:1899473-1899889 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp

>AT41920 NZ_AP026087:1899473-1899889 [Escherichia coli]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
GCAGGGCGAAACTGTCGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCTTTACCTTCGCCATTAAATAGTCATGATCACTTTATTGAAGTACCTTTGAGCGTCGCCTCTAAGGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAAGAGAT
TACTCGCCTATTTAACTTGCATCATGCGACAAAAATCGACGCCGTCCAGCTCGCGGCAAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References