Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 1159781..1160259 Replicon chromosome
Accession NZ_AP026087
Organism Escherichia coli strain 8_140198

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A891SFN9
Locus tag OO841_RS05390 Protein ID WP_001303876.1
Coordinates 1159781..1160068 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID Q8XD67
Locus tag OO841_RS05395 Protein ID WP_000536233.1
Coordinates 1160068..1160259 (-) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OO841_RS05355 (1154930) 1154930..1157401 - 2472 WP_000034474.1 exonuclease -
OO841_RS05360 (1157495) 1157495..1157686 - 192 WP_001098307.1 DUF1482 family protein -
OO841_RS05365 (1157683) 1157683..1157871 - 189 WP_000413705.1 cell division inhibition protein DicB -
OO841_RS05370 (1158445) 1158445..1158630 + 186 WP_001133046.1 hypothetical protein -
OO841_RS05375 (1158817) 1158817..1159206 - 390 WP_000394511.1 hypothetical protein -
OO841_RS05380 (1159218) 1159218..1159346 - 129 WP_000344963.1 protein YdfB -
OO841_RS05385 (1159348) 1159348..1159503 - 156 WP_000379575.1 DUF1391 family protein -
OO841_RS05390 (1159781) 1159781..1160068 - 288 WP_001303876.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OO841_RS05395 (1160068) 1160068..1160259 - 192 WP_000536233.1 hypothetical protein Antitoxin
OO841_RS05400 (1160287) 1160287..1160688 - 402 WP_000986592.1 helix-turn-helix domain-containing protein -
OO841_RS05405 (1160797) 1160797..1161069 + 273 WP_000887453.1 YdaS family helix-turn-helix protein -
OO841_RS05410 (1161053) 1161053..1161478 + 426 WP_000693855.1 toxin YdaT family protein -
OO841_RS05415 (1161685) 1161685..1162140 - 456 WP_000273724.1 hypothetical protein -
OO841_RS05420 (1162219) 1162219..1163310 + 1092 WP_001205823.1 hypothetical protein -
OO841_RS05425 (1163317) 1163317..1164063 + 747 WP_000788745.1 ATP-binding protein -
OO841_RS05430 (1164085) 1164085..1164855 + 771 WP_000450992.1 DUF1627 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10978.84 Da        Isoelectric Point: 10.1360

>T41912 WP_001303876.1 NZ_AP026087:c1160068-1159781 [Escherichia coli]
MLPILWLPSARDDLRQIITYIAKENPPAARRLKIRIETSVLPLSEHPYLYPPSERVSGLREIVTHPNYIILYRVAASSIE
IVSVTHSRRQFPFSI

Download         Length: 288 bp

>T41912 NZ_AP026087:c1160068-1159781 [Escherichia coli]
ATGTTACCCATTTTATGGCTACCGTCTGCTCGCGATGATTTGCGCCAGATCATAACTTACATCGCCAAGGAGAACCCACC
GGCAGCACGTAGACTAAAAATACGCATTGAAACATCGGTATTACCTCTATCTGAGCATCCGTACTTATATCCACCAAGCG
AACGGGTTTCTGGATTGAGAGAGATCGTGACCCACCCTAACTACATAATCCTGTACAGAGTAGCTGCTTCAAGCATTGAG
ATTGTAAGCGTGACACATTCTCGGCGACAATTTCCCTTCTCTATCTGA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7025.80 Da        Isoelectric Point: 4.0270

>AT41912 WP_000536233.1 NZ_AP026087:c1160259-1160068 [Escherichia coli]
MGTALSPIVSEFETTEQENSYNEWLRTKVTSSLADTRPAIPHDEVMAEMENLIAQIAVTNKSE

Download         Length: 192 bp

>AT41912 NZ_AP026087:c1160259-1160068 [Escherichia coli]
ATGGGTACAGCCCTTTCTCCGATAGTTTCAGAATTCGAAACTACCGAACAAGAAAACAGTTACAACGAATGGTTGCGCAC
TAAAGTAACGTCAAGCCTTGCAGACACTCGCCCCGCAATTCCACATGACGAGGTAATGGCTGAAATGGAAAATCTTATTG
CTCAAATTGCTGTAACTAACAAGAGCGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References