Detailed information of TA system TA041901

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): chpSB/PRK09812-ChpS
• Location: 5235677..5236272
• Replicon: chromosome
• Accession: NZ_AP026085
• Organism: Escherichia coli strain H52_982342

Toxin (Protein)

• Gene name: chpB
• Uniprot ID: U9Y4M4
• Locus tag: OO840_RS26145
• Protein ID: WP_000239579.1
• Coordinates: 5235922..5236272 (+)
• Length: 117 a.a.

Antitoxin (Protein)

• Gene name: chpS
• Uniprot ID: Q8XCF3
• Locus tag: OO840_RS26140
• Protein ID: WP_001223210.1
• Coordinates: 5235677..5235928 (+)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
OO840_RS26130 (5231342)	5231342..5235121	+	3780	WP_000060931.1	autotransporter assembly complex protein TamB	-
OO840_RS26135 (5235124)	5235124..5235465	+	342	WP_001219160.1	gamma-glutamylcyclotransferase	-
OO840_RS26140 (5235677)	5235677..5235928	+	252	WP_001223210.1	type II toxin-antitoxin system antitoxin ChpS	Antitoxin
OO840_RS26145 (5235922)	5235922..5236272	+	351	WP_000239579.1	endoribonuclease toxin ChpB	Toxin
OO840_RS26150 (5236352)	5236352..5236882	-	531	WP_000055075.1	inorganic diphosphatase	-
OO840_RS26155 (5237192)	5237192..5238148	+	957	WP_000265942.1	galactofuranose ABC transporter substrate-binding protein YtfQ	-
OO840_RS26160 (5238288)	5238288..5239790	+	1503	Protein_5112	sugar ABC transporter ATP-binding protein	-
OO840_RS26165 (5239804)	5239804..5240826	+	1023	WP_001301928.1	ABC transporter permease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (8-114)

Antitoxin

• SpoVT-AbrB domain (6-49)

Sequences

Toxin

Protein

• Length: 117 a.a.
• Molecular weight: 12511.45 Da
• Isoelectric Point: 5.6219

>T41901 WP_000239579.1 NZ_AP026085:5235922-5236272 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAADEVVEEALLRLQAVVE

Nucleotide

• Length: 351 bp

>T41901 NZ_AP026085:5235922-5236272 [Escherichia coli]
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GTGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTT
AATCAGGTGCGGATGATGGATCTACGCGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGATGAGGTGGTGGAAGAGGC
GTTATTACGCTTGCAGGCGGTGGTGGAATAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9299.64 Da
• Isoelectric Point: 4.4201

>AT41901 WP_001223210.1 NZ_AP026085:5235677-5235928 [Escherichia coli]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEVQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Nucleotide

• Length: 252 bp

>AT41901 NZ_AP026085:5235677-5235928 [Escherichia coli]
ATGCGTATTACCATAAAAAGATGGGGGAACAGTGCAGGTATGGTCATTCCCAATATCGTAATGAAAGAACTTAACTTACA
GCCGGGGCAGAGCGTGGAAGTGCAGGTGAGCAACAACCAACTGATTCTGACACCCATCTCCAGGCGCTACTCGCTTGATG
AACTGCTGGCACAGTGTGACATGAACGCCGCGGAACTTAGCGAGCAGGATGTCTGGGGTAAATCCACCCCTGCGGGTGAC
GAAATATGGTAA

Structures

Toxin

• AlphaFold DB: A0A0E0Y8A8