Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | paaR-paaA-parE/- |
Location | 2088367..2088838 | Replicon | chromosome |
Accession | NZ_AP026085 | ||
Organism | Escherichia coli strain H52_982342 |
Toxin (Protein)
Gene name | parE_1 | Uniprot ID | A0A0D7C2L1 |
Locus tag | OO840_RS10345 | Protein ID | WP_001303511.1 |
Coordinates | 2088560..2088838 (+) | Length | 93 a.a. |
Antitoxin (Protein)
Gene name | paaA | Uniprot ID | Q8XAD5 |
Locus tag | OO840_RS10340 | Protein ID | WP_001302048.1 |
Coordinates | 2088367..2088558 (+) | Length | 64 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
OO840_RS10300 (2083574) | 2083574..2084158 | - | 585 | WP_000206793.1 | DUF551 domain-containing protein | - |
OO840_RS10305 (2084215) | 2084215..2084610 | - | 396 | WP_001118159.1 | DUF977 family protein | - |
OO840_RS10310 (2084626) | 2084626..2085395 | - | 770 | Protein_2024 | DUF1627 domain-containing protein | - |
OO840_RS10315 (2085421) | 2085421..2086161 | - | 741 | WP_000788938.1 | ATP-binding protein | - |
OO840_RS10320 (2086168) | 2086168..2087130 | - | 963 | WP_000095669.1 | helix-turn-helix domain-containing protein | - |
OO840_RS10325 (2087153) | 2087153..2087578 | - | 426 | WP_000693943.1 | toxin YdaT family protein | - |
OO840_RS10330 (2087575) | 2087575..2087877 | - | 303 | WP_000172738.1 | transcriptional regulator | - |
OO840_RS10335 (2087975) | 2087975..2088346 | + | 372 | WP_001169686.1 | hypothetical protein | - |
OO840_RS10340 (2088367) | 2088367..2088558 | + | 192 | WP_001302048.1 | hypothetical protein | Antitoxin |
OO840_RS10345 (2088560) | 2088560..2088838 | + | 279 | WP_001303511.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
OO840_RS10350 (2089190) | 2089190..2089489 | + | 300 | WP_001240334.1 | hypothetical protein | - |
OO840_RS10355 (2089561) | 2089561..2089779 | + | 219 | WP_001171930.1 | protein YdfC | - |
OO840_RS10360 (2090348) | 2090348..2090536 | + | 189 | WP_000449192.1 | cell division inhibition protein DicB | - |
OO840_RS10365 (2090533) | 2090533..2090724 | + | 192 | WP_001090200.1 | DUF1482 family protein | - |
OO840_RS10370 (2090817) | 2090817..2093288 | + | 2472 | WP_000048458.1 | exonuclease | - |
OO840_RS10375 (2093361) | 2093361..2093612 | + | 252 | WP_000005552.1 | excisionase family protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Prophage | - | - | 2046882..2103717 | 56835 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 93 a.a. Molecular weight: 10661.25 Da Isoelectric Point: 5.5647
>T41882 WP_001303511.1 NZ_AP026085:2088560-2088838 [Escherichia coli]
MLPVLWLESADTDLDDITSYIARFDIDAAERLWQRLRGCVLPLSEHPYLYPPSDRVPGLREIVAHPNYIILYRVTTSSVE
VVNVIHARRQFP
MLPVLWLESADTDLDDITSYIARFDIDAAERLWQRLRGCVLPLSEHPYLYPPSDRVPGLREIVAHPNYIILYRVTTSSVE
VVNVIHARRQFP
Download Length: 279 bp
>T41882 NZ_AP026085:2088560-2088838 [Escherichia coli]
ATGTTACCCGTGTTATGGCTTGAAAGCGCAGATACCGACCTAGATGATATAACTAGTTATATTGCTCGTTTCGACATAGA
TGCGGCTGAACGCTTATGGCAGCGATTAAGGGGTTGTGTGCTGCCGTTATCCGAACATCCGTATTTATACCCACCAAGCG
ACAGAGTACCTGGCTTGCGTGAGATTGTAGCCCACCCTAACTATATAATTCTATACCGCGTAACAACATCAAGCGTTGAA
GTAGTAAACGTGATCCACGCAAGACGCCAGTTTCCCTAA
ATGTTACCCGTGTTATGGCTTGAAAGCGCAGATACCGACCTAGATGATATAACTAGTTATATTGCTCGTTTCGACATAGA
TGCGGCTGAACGCTTATGGCAGCGATTAAGGGGTTGTGTGCTGCCGTTATCCGAACATCCGTATTTATACCCACCAAGCG
ACAGAGTACCTGGCTTGCGTGAGATTGTAGCCCACCCTAACTATATAATTCTATACCGCGTAACAACATCAAGCGTTGAA
GTAGTAAACGTGATCCACGCAAGACGCCAGTTTCCCTAA
Antitoxin
Download Length: 64 a.a. Molecular weight: 7463.47 Da Isoelectric Point: 8.6828
>AT41882 WP_001302048.1 NZ_AP026085:2088367-2088558 [Escherichia coli]
MNRALSPMVSEFETIEQENSYNEWLRAKVATSLADPRPAIPHDEVERRMAERFAKMRKERSKQ
MNRALSPMVSEFETIEQENSYNEWLRAKVATSLADPRPAIPHDEVERRMAERFAKMRKERSKQ
Download Length: 192 bp
>AT41882 NZ_AP026085:2088367-2088558 [Escherichia coli]
ATGAATAGAGCCCTTTCACCAATGGTTTCTGAATTTGAAACCATTGAACAAGAAAACAGTTACAACGAATGGCTGCGTGC
GAAAGTAGCAACGAGCCTTGCAGATCCGCGCCCAGCAATTCCCCATGACGAAGTTGAGCGCAGAATGGCAGAACGCTTTG
CTAAGATGCGCAAGGAACGGAGCAAGCAGTAA
ATGAATAGAGCCCTTTCACCAATGGTTTCTGAATTTGAAACCATTGAACAAGAAAACAGTTACAACGAATGGCTGCGTGC
GAAAGTAGCAACGAGCCTTGCAGATCCGCGCCCAGCAATTCCCCATGACGAAGTTGAGCGCAGAATGGCAGAACGCTTTG
CTAAGATGCGCAAGGAACGGAGCAAGCAGTAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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