Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 2088367..2088838 Replicon chromosome
Accession NZ_AP026085
Organism Escherichia coli strain H52_982342

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A0D7C2L1
Locus tag OO840_RS10345 Protein ID WP_001303511.1
Coordinates 2088560..2088838 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID Q8XAD5
Locus tag OO840_RS10340 Protein ID WP_001302048.1
Coordinates 2088367..2088558 (+) Length 64 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OO840_RS10300 (2083574) 2083574..2084158 - 585 WP_000206793.1 DUF551 domain-containing protein -
OO840_RS10305 (2084215) 2084215..2084610 - 396 WP_001118159.1 DUF977 family protein -
OO840_RS10310 (2084626) 2084626..2085395 - 770 Protein_2024 DUF1627 domain-containing protein -
OO840_RS10315 (2085421) 2085421..2086161 - 741 WP_000788938.1 ATP-binding protein -
OO840_RS10320 (2086168) 2086168..2087130 - 963 WP_000095669.1 helix-turn-helix domain-containing protein -
OO840_RS10325 (2087153) 2087153..2087578 - 426 WP_000693943.1 toxin YdaT family protein -
OO840_RS10330 (2087575) 2087575..2087877 - 303 WP_000172738.1 transcriptional regulator -
OO840_RS10335 (2087975) 2087975..2088346 + 372 WP_001169686.1 hypothetical protein -
OO840_RS10340 (2088367) 2088367..2088558 + 192 WP_001302048.1 hypothetical protein Antitoxin
OO840_RS10345 (2088560) 2088560..2088838 + 279 WP_001303511.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OO840_RS10350 (2089190) 2089190..2089489 + 300 WP_001240334.1 hypothetical protein -
OO840_RS10355 (2089561) 2089561..2089779 + 219 WP_001171930.1 protein YdfC -
OO840_RS10360 (2090348) 2090348..2090536 + 189 WP_000449192.1 cell division inhibition protein DicB -
OO840_RS10365 (2090533) 2090533..2090724 + 192 WP_001090200.1 DUF1482 family protein -
OO840_RS10370 (2090817) 2090817..2093288 + 2472 WP_000048458.1 exonuclease -
OO840_RS10375 (2093361) 2093361..2093612 + 252 WP_000005552.1 excisionase family protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2046882..2103717 56835


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(4-91)

Antitoxin


No domain identified.



Sequences


Toxin        


Download         Length: 93 a.a.        Molecular weight: 10661.25 Da        Isoelectric Point: 5.5647

>T41882 WP_001303511.1 NZ_AP026085:2088560-2088838 [Escherichia coli]
MLPVLWLESADTDLDDITSYIARFDIDAAERLWQRLRGCVLPLSEHPYLYPPSDRVPGLREIVAHPNYIILYRVTTSSVE
VVNVIHARRQFP

Download         Length: 279 bp

>T41882 NZ_AP026085:2088560-2088838 [Escherichia coli]
ATGTTACCCGTGTTATGGCTTGAAAGCGCAGATACCGACCTAGATGATATAACTAGTTATATTGCTCGTTTCGACATAGA
TGCGGCTGAACGCTTATGGCAGCGATTAAGGGGTTGTGTGCTGCCGTTATCCGAACATCCGTATTTATACCCACCAAGCG
ACAGAGTACCTGGCTTGCGTGAGATTGTAGCCCACCCTAACTATATAATTCTATACCGCGTAACAACATCAAGCGTTGAA
GTAGTAAACGTGATCCACGCAAGACGCCAGTTTCCCTAA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7463.47 Da        Isoelectric Point: 8.6828

>AT41882 WP_001302048.1 NZ_AP026085:2088367-2088558 [Escherichia coli]
MNRALSPMVSEFETIEQENSYNEWLRAKVATSLADPRPAIPHDEVERRMAERFAKMRKERSKQ

Download         Length: 192 bp

>AT41882 NZ_AP026085:2088367-2088558 [Escherichia coli]
ATGAATAGAGCCCTTTCACCAATGGTTTCTGAATTTGAAACCATTGAACAAGAAAACAGTTACAACGAATGGCTGCGTGC
GAAAGTAGCAACGAGCCTTGCAGATCCGCGCCCAGCAATTCCCCATGACGAAGTTGAGCGCAGAATGGCAGAACGCTTTG
CTAAGATGCGCAAGGAACGGAGCAAGCAGTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
PDB 5CZF
PDB 5CW7
PDB 5CZE


Antitoxin

Source ID Structure
PDB 5CZF
PDB 3ZBE
PDB 5CW7
AlphaFold DB A0A829CTP0

References