Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 1915031..1915669 Replicon chromosome
Accession NZ_AP026085
Organism Escherichia coli strain H52_982342

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag OO840_RS09485 Protein ID WP_000813794.1
Coordinates 1915031..1915207 (+) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag OO840_RS09490 Protein ID WP_001270286.1
Coordinates 1915253..1915669 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OO840_RS09465 (1910652) 1910652..1911825 - 1174 Protein_1859 BenE family transporter YdcO -
OO840_RS09470 (1911917) 1911917..1912453 + 537 WP_000429145.1 DNA-binding transcriptional regulator SutR -
OO840_RS09475 (1912526) 1912526..1914487 + 1962 WP_001303492.1 23S rRNA 5-hydroxycytidine C2501 synthase -
OO840_RS09480 (1914579) 1914579..1914809 - 231 WP_000494244.1 YncJ family protein -
OO840_RS09485 (1915031) 1915031..1915207 + 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
OO840_RS09490 (1915253) 1915253..1915669 + 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
OO840_RS09495 (1915748) 1915748..1917154 + 1407 WP_000760654.1 PLP-dependent aminotransferase family protein -
OO840_RS09500 (1917399) 1917399..1918544 + 1146 WP_000047432.1 ABC transporter substrate-binding protein -
OO840_RS09505 (1918562) 1918562..1919575 + 1014 WP_000220402.1 ABC transporter ATP-binding protein -
OO840_RS09510 (1919576) 1919576..1920517 + 942 WP_001251315.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T41881 WP_000813794.1 NZ_AP026085:1915031-1915207 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

>T41881 NZ_AP026085:1915031-1915207 [Escherichia coli]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTGAAACTCAG
GTTTCATGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT41881 WP_001270286.1 NZ_AP026085:1915253-1915669 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp

>AT41881 NZ_AP026085:1915253-1915669 [Escherichia coli]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
GCAGGGCGAAACTGTCGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCTTTACCTTCGCCATTAAATAGTCATGATCACTTTATTGAAGTACCTTTGAGCGTCGCCTCTAAGGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAAGAGAT
TACTCGCCTATTTAACTTGCATCATGCGACAAAAATCGACGCCGTCCAGCTCGCGGCAAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References