Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 1171127..1171605 Replicon chromosome
Accession NZ_AP026085
Organism Escherichia coli strain H52_982342

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A891SFN9
Locus tag OO840_RS05415 Protein ID WP_001303876.1
Coordinates 1171127..1171414 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID Q8XD67
Locus tag OO840_RS05420 Protein ID WP_000536233.1
Coordinates 1171414..1171605 (-) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OO840_RS05380 (1166276) 1166276..1168747 - 2472 WP_000034474.1 exonuclease -
OO840_RS05385 (1168841) 1168841..1169032 - 192 WP_001098307.1 DUF1482 family protein -
OO840_RS05390 (1169029) 1169029..1169217 - 189 WP_000413705.1 cell division inhibition protein DicB -
OO840_RS05395 (1169791) 1169791..1169976 + 186 WP_001133046.1 hypothetical protein -
OO840_RS05400 (1170163) 1170163..1170552 - 390 WP_000394511.1 hypothetical protein -
OO840_RS05405 (1170564) 1170564..1170692 - 129 WP_000344963.1 protein YdfB -
OO840_RS05410 (1170694) 1170694..1170849 - 156 WP_000379575.1 DUF1391 family protein -
OO840_RS05415 (1171127) 1171127..1171414 - 288 WP_001303876.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OO840_RS05420 (1171414) 1171414..1171605 - 192 WP_000536233.1 hypothetical protein Antitoxin
OO840_RS05425 (1171633) 1171633..1172034 - 402 WP_000986592.1 helix-turn-helix domain-containing protein -
OO840_RS05430 (1172143) 1172143..1172415 + 273 WP_000887453.1 YdaS family helix-turn-helix protein -
OO840_RS05435 (1172399) 1172399..1172824 + 426 WP_000693855.1 toxin YdaT family protein -
OO840_RS05440 (1173031) 1173031..1173486 - 456 WP_000273724.1 hypothetical protein -
OO840_RS05445 (1173565) 1173565..1174656 + 1092 WP_001205823.1 hypothetical protein -
OO840_RS05450 (1174663) 1174663..1175409 + 747 WP_000788745.1 ATP-binding protein -
OO840_RS05455 (1175431) 1175431..1176201 + 771 WP_000450992.1 DUF1627 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10978.84 Da        Isoelectric Point: 10.1360

>T41877 WP_001303876.1 NZ_AP026085:c1171414-1171127 [Escherichia coli]
MLPILWLPSARDDLRQIITYIAKENPPAARRLKIRIETSVLPLSEHPYLYPPSERVSGLREIVTHPNYIILYRVAASSIE
IVSVTHSRRQFPFSI

Download         Length: 288 bp

>T41877 NZ_AP026085:c1171414-1171127 [Escherichia coli]
ATGTTACCCATTTTATGGCTACCGTCTGCTCGCGATGATTTGCGCCAGATCATAACTTACATCGCCAAGGAGAACCCACC
GGCAGCACGTAGACTAAAAATACGCATTGAAACATCGGTATTACCTCTATCTGAGCATCCGTACTTATATCCACCAAGCG
AACGGGTTTCTGGATTGAGAGAGATCGTGACCCACCCTAACTACATAATCCTGTACAGAGTAGCTGCTTCAAGCATTGAG
ATTGTAAGCGTGACACATTCTCGGCGACAATTTCCCTTCTCTATCTGA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7025.80 Da        Isoelectric Point: 4.0270

>AT41877 WP_000536233.1 NZ_AP026085:c1171605-1171414 [Escherichia coli]
MGTALSPIVSEFETTEQENSYNEWLRTKVTSSLADTRPAIPHDEVMAEMENLIAQIAVTNKSE

Download         Length: 192 bp

>AT41877 NZ_AP026085:c1171605-1171414 [Escherichia coli]
ATGGGTACAGCCCTTTCTCCGATAGTTTCAGAATTCGAAACTACCGAACAAGAAAACAGTTACAACGAATGGTTGCGCAC
TAAAGTAACGTCAAGCCTTGCAGACACTCGCCCCGCAATTCCACATGACGAGGTAATGGCTGAAATGGAAAATCTTATTG
CTCAAATTGCTGTAACTAACAAGAGCGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References