Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-HTH_XRE
Location 1004760..1005465 Replicon chromosome
Accession NZ_AP026085
Organism Escherichia coli strain H52_982342

Toxin (Protein)


Gene name relE Uniprot ID Q8X3N0
Locus tag OO840_RS04660 Protein ID WP_000539519.1
Coordinates 1005079..1005465 (-) Length 129 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag OO840_RS04655 Protein ID WP_001280945.1
Coordinates 1004760..1005089 (-) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OO840_RS04640 (999917) 999917..1000828 + 912 WP_001236044.1 glutathione ABC transporter permease GsiD -
OO840_RS04645 (1001006) 1001006..1003354 + 2349 WP_000950320.1 EAL domain-containing protein -
OO840_RS04650 (1003362) 1003362..1004690 + 1329 WP_000086905.1 GGDEF domain-containing protein -
OO840_RS04655 (1004760) 1004760..1005089 - 330 WP_001280945.1 DNA-binding transcriptional regulator Antitoxin
OO840_RS04660 (1005079) 1005079..1005465 - 387 WP_000539519.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OO840_RS04665 (1005691) 1005691..1007016 - 1326 WP_000049367.1 30S ribosomal protein S12 methylthiotransferase RimO -
OO840_RS04670 (1007229) 1007229..1007612 + 384 WP_000497137.1 biofilm formation regulator BssR -
OO840_RS04675 (1007723) 1007723..1008838 + 1116 WP_000554959.1 aldose sugar dehydrogenase YliI -
OO840_RS04680 (1008835) 1008835..1009461 - 627 WP_001295292.1 glutathione S-transferase GstB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(1-124)

Antitoxin

Cro/C1-type helix-turn-helix domain

(53-94)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14279.42 Da        Isoelectric Point: 9.9296

>T41876 WP_000539519.1 NZ_AP026085:c1005465-1005079 [Escherichia coli]
MGVYKARRFSQSTKKLGIHDKVLMAAAEEVMQGIWEADLGSGVIKKRLPLQQGKSGGARTIIFFKSANHVFFYDGWSKSG
LSSKGSKEIEDDELAAYKKMANAFLAFSNKQIEDLIETGFLIEVKNER

Download         Length: 387 bp

>T41876 NZ_AP026085:c1005465-1005079 [Escherichia coli]
ATGGGTGTGTATAAGGCAAGGCGATTCAGCCAAAGCACGAAAAAACTTGGTATTCACGATAAAGTTCTCATGGCTGCCGC
TGAAGAAGTGATGCAAGGCATATGGGAGGCTGATTTAGGTAGCGGTGTCATCAAAAAACGGTTACCCCTCCAACAAGGAA
AGAGTGGTGGAGCCAGAACAATTATCTTTTTTAAATCAGCAAATCATGTGTTTTTTTATGATGGTTGGTCCAAGAGTGGT
CTAAGCAGTAAAGGAAGCAAAGAAATCGAAGATGATGAACTGGCAGCCTACAAAAAAATGGCAAATGCATTTCTGGCCTT
TAGCAATAAGCAAATAGAGGATTTGATCGAAACTGGCTTCTTGATTGAGGTGAAAAATGAGCGATAA

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 11982.08 Da        Isoelectric Point: 10.0101

>AT41876 WP_001280945.1 NZ_AP026085:c1005089-1004760 [Escherichia coli]
MSDKLQMMLEDAKELNALGLMSDSEVDAIAVMVKAREVSARIAKVKSMTGEEIKAIRTRYGMSQSVLAHTMGMSKESVSK
WERNEIKPSGPALRILNTLAIKGPEVFAK

Download         Length: 330 bp

>AT41876 NZ_AP026085:c1005089-1004760 [Escherichia coli]
ATGAGCGATAAATTACAAATGATGCTGGAAGATGCAAAGGAACTGAATGCACTGGGCCTGATGTCTGATAGTGAGGTTGA
TGCCATTGCCGTCATGGTCAAAGCCCGTGAAGTCAGCGCCCGTATAGCCAAAGTCAAATCAATGACGGGTGAAGAGATCA
AAGCCATCCGCACCCGATACGGCATGTCACAATCCGTGCTGGCACATACAATGGGAATGTCAAAAGAAAGTGTCTCGAAA
TGGGAACGTAATGAAATAAAACCGAGCGGCCCGGCACTACGTATTTTGAATACATTGGCAATAAAAGGGCCGGAAGTTTT
TGCAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References