Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3764606..3765260 Replicon chromosome
Accession NZ_AP026082
Organism Escherichia coli strain F765

Toxin (Protein)


Gene name cptA Uniprot ID S1PAM6
Locus tag OO934_RS19035 Protein ID WP_000244781.1
Coordinates 3764606..3765013 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag OO934_RS19040 Protein ID WP_000354046.1
Coordinates 3764994..3765260 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OO934_RS19015 (3760563) 3760563..3762296 - 1734 WP_000813185.1 single-stranded-DNA-specific exonuclease RecJ -
OO934_RS19020 (3762302) 3762302..3763012 - 711 WP_000715214.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
OO934_RS19025 (3763037) 3763037..3763933 - 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
OO934_RS19030 (3764045) 3764045..3764566 + 522 WP_001055874.1 flavodoxin FldB -
OO934_RS19035 (3764606) 3764606..3765013 - 408 WP_000244781.1 protein YgfX Toxin
OO934_RS19040 (3764994) 3764994..3765260 - 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
OO934_RS19045 (3765503) 3765503..3766483 + 981 WP_000886053.1 tRNA-modifying protein YgfZ -
OO934_RS19050 (3766560) 3766560..3767219 - 660 WP_000250274.1 hemolysin III family protein -
OO934_RS19055 (3767383) 3767383..3767694 - 312 WP_001182957.1 N(4)-acetylcytidine aminohydrolase -
OO934_RS19060 (3767739) 3767739..3769172 + 1434 WP_001310226.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16061.99 Da        Isoelectric Point: 11.5202

>T41857 WP_000244781.1 NZ_AP026082:c3765013-3764606 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

>T41857 NZ_AP026082:c3765013-3764606 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCGCCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATAGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT41857 WP_000354046.1 NZ_AP026082:c3765260-3764994 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT41857 NZ_AP026082:c3765260-3764994 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTATGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCCGATC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PAM6

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References