Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 2134980..2135451 Replicon chromosome
Accession NZ_AP026082
Organism Escherichia coli strain F765

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A0D7C2L1
Locus tag OO934_RS10670 Protein ID WP_001303511.1
Coordinates 2135173..2135451 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID Q8XAD5
Locus tag OO934_RS10665 Protein ID WP_001302048.1
Coordinates 2134980..2135171 (+) Length 64 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OO934_RS10625 (2130187) 2130187..2130771 - 585 WP_000206793.1 DUF551 domain-containing protein -
OO934_RS10630 (2130828) 2130828..2131223 - 396 WP_001118159.1 DUF977 family protein -
OO934_RS10635 (2131239) 2131239..2132008 - 770 Protein_2087 DUF1627 domain-containing protein -
OO934_RS10640 (2132034) 2132034..2132774 - 741 WP_000788938.1 ATP-binding protein -
OO934_RS10645 (2132781) 2132781..2133743 - 963 WP_000095669.1 helix-turn-helix domain-containing protein -
OO934_RS10650 (2133766) 2133766..2134191 - 426 WP_000693943.1 toxin YdaT family protein -
OO934_RS10655 (2134188) 2134188..2134490 - 303 WP_000172738.1 transcriptional regulator -
OO934_RS10660 (2134588) 2134588..2134959 + 372 WP_001169686.1 hypothetical protein -
OO934_RS10665 (2134980) 2134980..2135171 + 192 WP_001302048.1 hypothetical protein Antitoxin
OO934_RS10670 (2135173) 2135173..2135451 + 279 WP_001303511.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OO934_RS10675 (2135803) 2135803..2136102 + 300 WP_001240334.1 hypothetical protein -
OO934_RS10680 (2136174) 2136174..2136392 + 219 WP_001171930.1 protein YdfC -
OO934_RS10685 (2136961) 2136961..2137149 + 189 WP_000449192.1 cell division inhibition protein DicB -
OO934_RS10690 (2137146) 2137146..2137337 + 192 WP_001090200.1 DUF1482 family protein -
OO934_RS10695 (2137430) 2137430..2139901 + 2472 WP_000048458.1 exonuclease -
OO934_RS10700 (2139974) 2139974..2140225 + 252 WP_000005552.1 excisionase family protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - nleG7' 2045575..2150330 104755


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(4-91)

Antitoxin


No domain identified.



Sequences


Toxin        


Download         Length: 93 a.a.        Molecular weight: 10661.25 Da        Isoelectric Point: 5.5647

>T41847 WP_001303511.1 NZ_AP026082:2135173-2135451 [Escherichia coli]
MLPVLWLESADTDLDDITSYIARFDIDAAERLWQRLRGCVLPLSEHPYLYPPSDRVPGLREIVAHPNYIILYRVTTSSVE
VVNVIHARRQFP

Download         Length: 279 bp

>T41847 NZ_AP026082:2135173-2135451 [Escherichia coli]
ATGTTACCCGTGTTATGGCTTGAAAGCGCAGATACCGACCTAGATGATATAACTAGTTATATTGCTCGTTTCGACATAGA
TGCGGCTGAACGCTTATGGCAGCGATTAAGGGGTTGTGTGCTGCCGTTATCCGAACATCCGTATTTATACCCACCAAGCG
ACAGAGTACCTGGCTTGCGTGAGATTGTAGCCCACCCTAACTATATAATTCTATACCGCGTAACAACATCAAGCGTTGAA
GTAGTAAACGTGATCCACGCAAGACGCCAGTTTCCCTAA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7463.47 Da        Isoelectric Point: 8.6828

>AT41847 WP_001302048.1 NZ_AP026082:2134980-2135171 [Escherichia coli]
MNRALSPMVSEFETIEQENSYNEWLRAKVATSLADPRPAIPHDEVERRMAERFAKMRKERSKQ

Download         Length: 192 bp

>AT41847 NZ_AP026082:2134980-2135171 [Escherichia coli]
ATGAATAGAGCCCTTTCACCAATGGTTTCTGAATTTGAAACCATTGAACAAGAAAACAGTTACAACGAATGGCTGCGTGC
GAAAGTAGCAACGAGCCTTGCAGATCCGCGCCCAGCAATTCCCCATGACGAAGTTGAGCGCAGAATGGCAGAACGCTTTG
CTAAGATGCGCAAGGAACGGAGCAAGCAGTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
PDB 5CZF
PDB 5CW7
PDB 5CZE


Antitoxin

Source ID Structure
PDB 5CZF
PDB 3ZBE
PDB 5CW7
AlphaFold DB A0A829CTP0

References