Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 1913724..1914362 Replicon chromosome
Accession NZ_AP026082
Organism Escherichia coli strain F765

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag OO934_RS09475 Protein ID WP_000813794.1
Coordinates 1913724..1913900 (+) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag OO934_RS09480 Protein ID WP_001270286.1
Coordinates 1913946..1914362 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OO934_RS09455 (1909345) 1909345..1910518 - 1174 Protein_1857 BenE family transporter YdcO -
OO934_RS09460 (1910610) 1910610..1911146 + 537 WP_000429145.1 DNA-binding transcriptional regulator SutR -
OO934_RS09465 (1911219) 1911219..1913180 + 1962 WP_001303492.1 23S rRNA 5-hydroxycytidine C2501 synthase -
OO934_RS09470 (1913272) 1913272..1913502 - 231 WP_000494244.1 YncJ family protein -
OO934_RS09475 (1913724) 1913724..1913900 + 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
OO934_RS09480 (1913946) 1913946..1914362 + 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
OO934_RS09485 (1914441) 1914441..1915847 + 1407 WP_000760654.1 PLP-dependent aminotransferase family protein -
OO934_RS09490 (1916092) 1916092..1917237 + 1146 WP_000047432.1 ABC transporter substrate-binding protein -
OO934_RS09495 (1917255) 1917255..1918268 + 1014 WP_000220402.1 ABC transporter ATP-binding protein -
OO934_RS09500 (1918269) 1918269..1919210 + 942 WP_001251315.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T41844 WP_000813794.1 NZ_AP026082:1913724-1913900 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

>T41844 NZ_AP026082:1913724-1913900 [Escherichia coli]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTGAAACTCAG
GTTTCATGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT41844 WP_001270286.1 NZ_AP026082:1913946-1914362 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp

>AT41844 NZ_AP026082:1913946-1914362 [Escherichia coli]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
GCAGGGCGAAACTGTCGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCTTTACCTTCGCCATTAAATAGTCATGATCACTTTATTGAAGTACCTTTGAGCGTCGCCTCTAAGGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAAGAGAT
TACTCGCCTATTTAACTTGCATCATGCGACAAAAATCGACGCCGTCCAGCTCGCGGCAAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References