Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 1169818..1170296 Replicon chromosome
Accession NZ_AP026082
Organism Escherichia coli strain F765

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A891SFN9
Locus tag OO934_RS05410 Protein ID WP_001303876.1
Coordinates 1169818..1170105 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID Q8XD67
Locus tag OO934_RS05415 Protein ID WP_000536233.1
Coordinates 1170105..1170296 (-) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OO934_RS05375 (1164967) 1164967..1167438 - 2472 WP_000034474.1 exonuclease -
OO934_RS05380 (1167532) 1167532..1167723 - 192 WP_001098307.1 DUF1482 family protein -
OO934_RS05385 (1167720) 1167720..1167908 - 189 WP_000413705.1 cell division inhibition protein DicB -
OO934_RS05390 (1168482) 1168482..1168667 + 186 WP_001133046.1 hypothetical protein -
OO934_RS05395 (1168854) 1168854..1169243 - 390 WP_000394511.1 hypothetical protein -
OO934_RS05400 (1169255) 1169255..1169383 - 129 WP_000344963.1 protein YdfB -
OO934_RS05405 (1169385) 1169385..1169540 - 156 WP_000379575.1 DUF1391 family protein -
OO934_RS05410 (1169818) 1169818..1170105 - 288 WP_001303876.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OO934_RS05415 (1170105) 1170105..1170296 - 192 WP_000536233.1 hypothetical protein Antitoxin
OO934_RS05420 (1170324) 1170324..1170725 - 402 WP_000986592.1 helix-turn-helix domain-containing protein -
OO934_RS05425 (1170834) 1170834..1171106 + 273 WP_000887453.1 YdaS family helix-turn-helix protein -
OO934_RS05430 (1171090) 1171090..1171515 + 426 WP_000693855.1 toxin YdaT family protein -
OO934_RS05435 (1171722) 1171722..1172177 - 456 WP_000273724.1 hypothetical protein -
OO934_RS05440 (1172256) 1172256..1173347 + 1092 WP_001205823.1 hypothetical protein -
OO934_RS05445 (1173354) 1173354..1174100 + 747 WP_000788745.1 ATP-binding protein -
OO934_RS05450 (1174122) 1174122..1174892 + 771 WP_000450992.1 DUF1627 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10978.84 Da        Isoelectric Point: 10.1360

>T41838 WP_001303876.1 NZ_AP026082:c1170105-1169818 [Escherichia coli]
MLPILWLPSARDDLRQIITYIAKENPPAARRLKIRIETSVLPLSEHPYLYPPSERVSGLREIVTHPNYIILYRVAASSIE
IVSVTHSRRQFPFSI

Download         Length: 288 bp

>T41838 NZ_AP026082:c1170105-1169818 [Escherichia coli]
ATGTTACCCATTTTATGGCTACCGTCTGCTCGCGATGATTTGCGCCAGATCATAACTTACATCGCCAAGGAGAACCCACC
GGCAGCACGTAGACTAAAAATACGCATTGAAACATCGGTATTACCTCTATCTGAGCATCCGTACTTATATCCACCAAGCG
AACGGGTTTCTGGATTGAGAGAGATCGTGACCCACCCTAACTACATAATCCTGTACAGAGTAGCTGCTTCAAGCATTGAG
ATTGTAAGCGTGACACATTCTCGGCGACAATTTCCCTTCTCTATCTGA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7025.80 Da        Isoelectric Point: 4.0270

>AT41838 WP_000536233.1 NZ_AP026082:c1170296-1170105 [Escherichia coli]
MGTALSPIVSEFETTEQENSYNEWLRTKVTSSLADTRPAIPHDEVMAEMENLIAQIAVTNKSE

Download         Length: 192 bp

>AT41838 NZ_AP026082:c1170296-1170105 [Escherichia coli]
ATGGGTACAGCCCTTTCTCCGATAGTTTCAGAATTCGAAACTACCGAACAAGAAAACAGTTACAACGAATGGTTGCGCAC
TAAAGTAACGTCAAGCCTTGCAGACACTCGCCCCGCAATTCCACATGACGAGGTAATGGCTGAAATGGAAAATCTTATTG
CTCAAATTGCTGTAACTAACAAGAGCGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References