Detailed information of TA system TA041827

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): chpSB/PRK09812-ChpS
• Location: 5276746..5277341
• Replicon: chromosome
• Accession: NZ_AP026080
• Organism: Escherichia coli strain F690

Toxin (Protein)

• Gene name: chpB
• Uniprot ID: U9Y4M4
• Locus tag: OO857_RS26405
• Protein ID: WP_000239579.1
• Coordinates: 5276991..5277341 (+)
• Length: 117 a.a.

Antitoxin (Protein)

• Gene name: chpS
• Uniprot ID: Q8XCF3
• Locus tag: OO857_RS26400
• Protein ID: WP_001223210.1
• Coordinates: 5276746..5276997 (+)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
OO857_RS26390 (5272411)	5272411..5276190	+	3780	WP_000060931.1	autotransporter assembly complex protein TamB	-
OO857_RS26395 (5276193)	5276193..5276534	+	342	WP_001219160.1	gamma-glutamylcyclotransferase	-
OO857_RS26400 (5276746)	5276746..5276997	+	252	WP_001223210.1	type II toxin-antitoxin system antitoxin ChpS	Antitoxin
OO857_RS26405 (5276991)	5276991..5277341	+	351	WP_000239579.1	endoribonuclease toxin ChpB	Toxin
OO857_RS26410 (5277421)	5277421..5277951	-	531	WP_000055075.1	inorganic diphosphatase	-
OO857_RS26415 (5278261)	5278261..5279217	+	957	WP_000265942.1	galactofuranose ABC transporter substrate-binding protein YtfQ	-
OO857_RS26420 (5279357)	5279357..5280859	+	1503	Protein_5162	sugar ABC transporter ATP-binding protein	-
OO857_RS26425 (5280873)	5280873..5281895	+	1023	WP_001301928.1	ABC transporter permease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (8-114)

Antitoxin

• SpoVT-AbrB domain (6-49)

Sequences

Toxin

Protein

• Length: 117 a.a.
• Molecular weight: 12511.45 Da
• Isoelectric Point: 5.6219

>T41827 WP_000239579.1 NZ_AP026080:5276991-5277341 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAADEVVEEALLRLQAVVE

Nucleotide

• Length: 351 bp

>T41827 NZ_AP026080:5276991-5277341 [Escherichia coli]
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GTGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTT
AATCAGGTGCGGATGATGGATCTACGCGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGATGAGGTGGTGGAAGAGGC
GTTATTACGCTTGCAGGCGGTGGTGGAATAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9299.64 Da
• Isoelectric Point: 4.4201

>AT41827 WP_001223210.1 NZ_AP026080:5276746-5276997 [Escherichia coli]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEVQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Nucleotide

• Length: 252 bp

>AT41827 NZ_AP026080:5276746-5276997 [Escherichia coli]
ATGCGTATTACCATAAAAAGATGGGGGAACAGTGCAGGTATGGTCATTCCCAATATCGTAATGAAAGAACTTAACTTACA
GCCGGGGCAGAGCGTGGAAGTGCAGGTGAGCAACAACCAACTGATTCTGACACCCATCTCCAGGCGCTACTCGCTTGATG
AACTGCTGGCACAGTGTGACATGAACGCCGCGGAACTTAGCGAGCAGGATGTCTGGGGTAAATCCACCCCTGCGGGTGAC
GAAATATGGTAA

Structures

Toxin

• AlphaFold DB: A0A0E0Y8A8