Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | paaR-paaA-parE/- |
| Location | 2138967..2139438 | Replicon | chromosome |
| Accession | NZ_AP026080 | ||
| Organism | Escherichia coli strain F690 | ||
Toxin (Protein)
| Gene name | parE_1 | Uniprot ID | A0A0D7C2L1 |
| Locus tag | OO857_RS10685 | Protein ID | WP_001303511.1 |
| Coordinates | 2139160..2139438 (+) | Length | 93 a.a. |
Antitoxin (Protein)
| Gene name | paaA | Uniprot ID | Q8XAD5 |
| Locus tag | OO857_RS10680 | Protein ID | WP_001302048.1 |
| Coordinates | 2138967..2139158 (+) | Length | 64 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| OO857_RS10640 (2134174) | 2134174..2134758 | - | 585 | WP_000206793.1 | DUF551 domain-containing protein | - |
| OO857_RS10645 (2134815) | 2134815..2135210 | - | 396 | WP_001118159.1 | DUF977 family protein | - |
| OO857_RS10650 (2135226) | 2135226..2135995 | - | 770 | Protein_2090 | DUF1627 domain-containing protein | - |
| OO857_RS10655 (2136021) | 2136021..2136761 | - | 741 | WP_000788938.1 | ATP-binding protein | - |
| OO857_RS10660 (2136768) | 2136768..2137730 | - | 963 | WP_000095669.1 | helix-turn-helix domain-containing protein | - |
| OO857_RS10665 (2137753) | 2137753..2138178 | - | 426 | WP_000693943.1 | toxin YdaT family protein | - |
| OO857_RS10670 (2138175) | 2138175..2138477 | - | 303 | WP_000172738.1 | transcriptional regulator | - |
| OO857_RS10675 (2138575) | 2138575..2138946 | + | 372 | WP_001169686.1 | hypothetical protein | - |
| OO857_RS10680 (2138967) | 2138967..2139158 | + | 192 | WP_001302048.1 | hypothetical protein | Antitoxin |
| OO857_RS10685 (2139160) | 2139160..2139438 | + | 279 | WP_001303511.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| OO857_RS10690 (2139790) | 2139790..2140089 | + | 300 | WP_001240334.1 | hypothetical protein | - |
| OO857_RS10695 (2140161) | 2140161..2140379 | + | 219 | WP_001171930.1 | protein YdfC | - |
| OO857_RS10700 (2140948) | 2140948..2141136 | + | 189 | WP_000449192.1 | cell division inhibition protein DicB | - |
| OO857_RS10705 (2141133) | 2141133..2141324 | + | 192 | WP_001090200.1 | DUF1482 family protein | - |
| OO857_RS10710 (2141417) | 2141417..2143888 | + | 2472 | WP_000048458.1 | exonuclease | - |
| OO857_RS10715 (2143961) | 2143961..2144212 | + | 252 | WP_000005552.1 | excisionase family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | nleG7' | 2049561..2154317 | 104756 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 93 a.a. Molecular weight: 10661.25 Da Isoelectric Point: 5.5647
>T41808 WP_001303511.1 NZ_AP026080:2139160-2139438 [Escherichia coli]
MLPVLWLESADTDLDDITSYIARFDIDAAERLWQRLRGCVLPLSEHPYLYPPSDRVPGLREIVAHPNYIILYRVTTSSVE
VVNVIHARRQFP
MLPVLWLESADTDLDDITSYIARFDIDAAERLWQRLRGCVLPLSEHPYLYPPSDRVPGLREIVAHPNYIILYRVTTSSVE
VVNVIHARRQFP
Download Length: 279 bp
>T41808 NZ_AP026080:2139160-2139438 [Escherichia coli]
ATGTTACCCGTGTTATGGCTTGAAAGCGCAGATACCGACCTAGATGATATAACTAGTTATATTGCTCGTTTCGACATAGA
TGCGGCTGAACGCTTATGGCAGCGATTAAGGGGTTGTGTGCTGCCGTTATCCGAACATCCGTATTTATACCCACCAAGCG
ACAGAGTACCTGGCTTGCGTGAGATTGTAGCCCACCCTAACTATATAATTCTATACCGCGTAACAACATCAAGCGTTGAA
GTAGTAAACGTGATCCACGCAAGACGCCAGTTTCCCTAA
ATGTTACCCGTGTTATGGCTTGAAAGCGCAGATACCGACCTAGATGATATAACTAGTTATATTGCTCGTTTCGACATAGA
TGCGGCTGAACGCTTATGGCAGCGATTAAGGGGTTGTGTGCTGCCGTTATCCGAACATCCGTATTTATACCCACCAAGCG
ACAGAGTACCTGGCTTGCGTGAGATTGTAGCCCACCCTAACTATATAATTCTATACCGCGTAACAACATCAAGCGTTGAA
GTAGTAAACGTGATCCACGCAAGACGCCAGTTTCCCTAA
Antitoxin
Download Length: 64 a.a. Molecular weight: 7463.47 Da Isoelectric Point: 8.6828
>AT41808 WP_001302048.1 NZ_AP026080:2138967-2139158 [Escherichia coli]
MNRALSPMVSEFETIEQENSYNEWLRAKVATSLADPRPAIPHDEVERRMAERFAKMRKERSKQ
MNRALSPMVSEFETIEQENSYNEWLRAKVATSLADPRPAIPHDEVERRMAERFAKMRKERSKQ
Download Length: 192 bp
>AT41808 NZ_AP026080:2138967-2139158 [Escherichia coli]
ATGAATAGAGCCCTTTCACCAATGGTTTCTGAATTTGAAACCATTGAACAAGAAAACAGTTACAACGAATGGCTGCGTGC
GAAAGTAGCAACGAGCCTTGCAGATCCGCGCCCAGCAATTCCCCATGACGAAGTTGAGCGCAGAATGGCAGAACGCTTTG
CTAAGATGCGCAAGGAACGGAGCAAGCAGTAA
ATGAATAGAGCCCTTTCACCAATGGTTTCTGAATTTGAAACCATTGAACAAGAAAACAGTTACAACGAATGGCTGCGTGC
GAAAGTAGCAACGAGCCTTGCAGATCCGCGCCCAGCAATTCCCCATGACGAAGTTGAGCGCAGAATGGCAGAACGCTTTG
CTAAGATGCGCAAGGAACGGAGCAAGCAGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|