Detailed information of TA system TA041794

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE(toxin)
• Location: 4582130..4582721
• Replicon: chromosome
• Accession: NZ_AP026075
• Organism: Acaryochloris marina MBIC10699

Toxin (Protein)

• Gene name: relE
• Uniprot ID: B0C588
• Locus tag: AM10699_RS20435
• Protein ID: WP_012161865.1
• Coordinates: 4582365..4582721 (+)
• Length: 119 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: B0C587
• Locus tag: AM10699_RS20430
• Protein ID: WP_012161864.1
• Coordinates: 4582130..4582375 (+)
• Length: 82 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AM10699_RS20405 (AM10699_40100)	4577168..4578352	+	1185	WP_012161859.1	DUF3596 domain-containing protein	-
AM10699_RS20410 (AM10699_40110)	4578356..4578634	-	279	WP_012161860.1	hypothetical protein	-
AM10699_RS20415 (AM10699_40120)	4578631..4578789	-	159	WP_012161861.1	hypothetical protein	-
AM10699_RS20420 (AM10699_40130)	4578836..4581106	-	2271	WP_012161862.1	AAA family ATPase	-
AM10699_RS20425 (AM10699_40140)	4581255..4581938	+	684	WP_012161863.1	helix-turn-helix transcriptional regulator	-
AM10699_RS20430 (AM10699_40150)	4582130..4582375	+	246	WP_012161864.1	hypothetical protein	Antitoxin
AM10699_RS20435 (AM10699_40160)	4582365..4582721	+	357	WP_012161865.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
AM10699_RS20440	4582816..4583082	+	267	WP_041659243.1	hypothetical protein	-
AM10699_RS20445 (AM10699_40170)	4583061..4583579	+	519	WP_012161867.1	hypothetical protein	-
AM10699_RS20450 (AM10699_40180)	4583700..4583948	+	249	WP_261890723.1	hypothetical protein	-
AM10699_RS20455 (AM10699_40190)	4583967..4584635	+	669	WP_261890724.1	ATP-binding protein	-
AM10699_RS20460 (AM10699_40200)	4584632..4585696	+	1065	WP_012161870.1	metal-dependent hydrolase	-
AM10699_RS20465 (AM10699_40210)	4585683..4586315	+	633	WP_238549174.1	hypothetical protein	-
AM10699_RS20470 (AM10699_40220)	4586312..4586779	+	468	WP_261890725.1	hypothetical protein	-
AM10699_RS20475 (AM10699_40230)	4586781..4587068	+	288	WP_041660564.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-2 (58-108)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 119 a.a.
• Molecular weight: 13728.64 Da
• Isoelectric Point: 9.8730

>T41794 WP_012161865.1 NZ_AP026075:4582365-4582721 [Acaryochloris marina MBIC10699]
MPNNASDIEVALTHRFQRDLRTLAKRYRRIRSDVEPLIEQLQAGELPGDQITGIEYTLFKVRLKNSDIQKGKSAGYRVIY
YLKTQARIILVTIYSKSDRADIDNQTLREAIAQFEQDR

Nucleotide

• Length: 357 bp

>T41794 NZ_AP026075:4582365-4582721 [Acaryochloris marina MBIC10699]
ATGCCGAATAACGCATCAGATATTGAAGTTGCGCTAACCCATCGCTTTCAAAGGGATCTCCGCACCCTCGCTAAGCGCTA
TCGTCGCATTCGCTCCGATGTGGAACCCCTGATTGAGCAACTACAGGCTGGTGAGCTTCCAGGAGATCAGATTACAGGCA
TAGAATACACACTCTTCAAAGTTCGCCTCAAAAATAGTGATATTCAAAAGGGCAAGAGTGCGGGCTATCGGGTTATTTAC
TACCTCAAAACTCAAGCTCGGATCATCTTGGTAACCATCTATTCAAAGTCGGATCGAGCTGACATTGACAACCAAACCTT
GCGAGAAGCGATCGCACAATTTGAGCAAGACCGTTAA

Antitoxin

Protein

• Length: 82 a.a.
• Molecular weight: 9001.04 Da
• Isoelectric Point: 3.9129

>AT41794 WP_012161864.1 NZ_AP026075:4582130-4582375 [Acaryochloris marina MBIC10699]
MKAIETTATINDQGQLALDQPLELAQRRRVRVIVLISEEDEPDPDDTPNSVVMDGLRQGFHEALTGQTIPLSQMWDGIDA
E

Nucleotide

• Length: 246 bp

>AT41794 NZ_AP026075:4582130-4582375 [Acaryochloris marina MBIC10699]
ATGAAAGCGATTGAAACTACAGCAACCATTAATGATCAAGGGCAACTCGCCCTTGATCAGCCCCTTGAACTAGCTCAACG
TCGTCGGGTTAGAGTCATTGTCCTTATCTCAGAAGAAGACGAGCCGGATCCTGACGACACTCCAAACTCAGTCGTCATGG
ACGGTCTCCGTCAGGGGTTCCACGAAGCACTCACTGGTCAAACCATCCCTCTCTCGCAAATGTGGGATGGCATTGATGCC
GAATAA

Structures

Toxin

• AlphaFold DB: B0C588

Antitoxin

• AlphaFold DB: B0C587