Detailed information of TA system TA041793

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PumA-relB/COG3657-dnstrm_HI1420
• Location: 4310339..4310920
• Replicon: chromosome
• Accession: NZ_AP026075
• Organism: Acaryochloris marina MBIC10699

Toxin (Protein)

• Gene name: PumA
• Uniprot ID: B0C1R4
• Locus tag: AM10699_RS19260
• Protein ID: WP_012161638.1
• Coordinates: 4310339..4310623 (+)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: B0C1R5
• Locus tag: AM10699_RS19265
• Protein ID: WP_012161639.1
• Coordinates: 4310627..4310920 (+)
• Length: 98 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AM10699_RS19255 (AM10699_37860)	4306933..4309644	+	2712	WP_012161636.1	IS66 family transposase	-
AM10699_RS19260 (AM10699_37870)	4310339..4310623	+	285	WP_012161638.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
AM10699_RS19265 (AM10699_37880)	4310627..4310920	+	294	WP_012161639.1	putative addiction module antidote protein	Antitoxin
AM10699_RS19270 (AM10699_37890)	4311177..4311740	+	564	WP_012161640.1	Uma2 family endonuclease	-
AM10699_RS19275 (AM10699_37900)	4311831..4312049	+	219	WP_012161641.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	-
AM10699_RS19280 (AM10699_37910)	4312052..4312456	+	405	WP_041659114.1	type II toxin-antitoxin system VapC family toxin	-
AM10699_RS19285 (AM10699_37920)	4312599..4312763	+	165	WP_012161643.1	hypothetical protein	-
AM10699_RS19290 (AM10699_37930)	4312772..4313356	+	585	WP_012161644.1	DJ-1/PfpI family protein	-
AM10699_RS19295 (AM10699_37940)	4313425..4313859	+	435	WP_012161645.1	GNAT family N-acetyltransferase	-
AM10699_RS19300 (AM10699_37950)	4315077..4315589	+	513	WP_010467654.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	4315883..4316938	1055

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Addiction module killer protein, predicted (1-93)

Antitoxin

• Uncharacterized protein HI1420 (5-93)

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 10737.30 Da
• Isoelectric Point: 9.5338

>T41793 WP_012161638.1 NZ_AP026075:4310339-4310623 [Acaryochloris marina MBIC10699]
MIEVRQTDIFANWFNKLRDRKAKARIDRIEIGNFGDVAPIGEDVSELRMHYGSGYRVYFIQRGLVVVILIPGGDKGSQNA
DIKRAKEISKQLED

Nucleotide

• Length: 285 bp

>T41793 NZ_AP026075:4310339-4310623 [Acaryochloris marina MBIC10699]
ATGATTGAGGTCCGTCAAACAGACATTTTTGCCAATTGGTTCAATAAACTGCGAGATCGAAAGGCTAAAGCACGTATTGA
CCGTATCGAGATTGGCAATTTTGGGGATGTAGCCCCCATCGGGGAAGATGTTAGCGAACTTCGCATGCATTATGGTTCTG
GTTACAGGGTTTACTTTATACAACGTGGTCTAGTGGTTGTCATATTGATTCCTGGTGGTGACAAAGGCTCACAAAATGCT
GACATCAAAAGGGCTAAGGAAATTTCTAAGCAGTTGGAGGATTGA

Antitoxin

Protein

• Length: 98 a.a.
• Molecular weight: 10681.19 Da
• Isoelectric Point: 5.1131

>AT41793 WP_012161639.1 NZ_AP026075:4310627-4310920 [Acaryochloris marina MBIC10699]
MPINTTRWDSAEHLKTEEDIQLYLEACLEEAEDDPALIIHALGVVARAKNMSQLSRDTGLSREGLYKALSPDGNPKFSTI
AKVTKALGFKLTIQPTP

Nucleotide

• Length: 294 bp

>AT41793 NZ_AP026075:4310627-4310920 [Acaryochloris marina MBIC10699]
ATGCCCATAAACACAACCCGCTGGGATTCAGCGGAACATCTCAAAACAGAAGAAGATATTCAGCTATATCTAGAAGCATG
CCTGGAAGAAGCCGAAGATGATCCTGCTCTAATTATTCATGCACTAGGAGTAGTCGCTAGGGCTAAGAATATGAGTCAAC
TATCCCGAGATACGGGTTTGAGTAGAGAAGGGCTATATAAAGCGCTGTCTCCTGATGGTAACCCCAAATTTTCGACGATC
GCTAAAGTTACTAAAGCGCTCGGATTCAAGCTAACCATTCAGCCAACACCTTAG

Structures

Toxin

• AlphaFold DB: B0C1R4

Antitoxin

• AlphaFold DB: B0C1R5