Detailed information of TA system TA041792

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YoeB-RelB
• Location: 4153708..4154278
• Replicon: chromosome
• Accession: NZ_AP026075
• Organism: Acaryochloris marina MBIC10699

Toxin (Protein)

• Gene name: relE
• Uniprot ID: B0BYN7
• Locus tag: AM10699_RS18560
• Protein ID: WP_012161495.1
• Coordinates: 4153982..4154278 (+)
• Length: 99 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: B0BYN6
• Locus tag: AM10699_RS18555
• Protein ID: WP_012161494.1
• Coordinates: 4153708..4154001 (+)
• Length: 98 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AM10699_RS18525	4148977..4149549	-	573	Protein_3645	Uma2 family endonuclease	-
AM10699_RS18530 (AM10699_36420)	4149579..4150734	+	1156	WP_261890666.1	IS3-like element ISAcma13 family transposase	-
AM10699_RS18535 (AM10699_36430)	4150877..4151335	-	459	WP_012161490.1	urease accessory protein UreE	-
AM10699_RS18540 (AM10699_36440)	4151589..4152416	+	828	WP_012161491.1	phosphoadenosine phosphosulfate reductase	-
AM10699_RS18545 (AM10699_36450)	4152471..4152752	+	282	WP_012161492.1	hypothetical protein	-
AM10699_RS18550 (AM10699_36460)	4152821..4153606	+	786	WP_012161493.1	class I SAM-dependent methyltransferase	-
AM10699_RS18555 (AM10699_36470)	4153708..4154001	+	294	WP_012161494.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
AM10699_RS18560 (AM10699_36480)	4153982..4154278	+	297	WP_012161495.1	Txe/YoeB family addiction module toxin	Toxin
AM10699_RS18565 (AM10699_36490)	4154291..4154935	-	645	WP_012161496.1	DUF4033 domain-containing protein	-
AM10699_RS18570 (AM10699_36500)	4155049..4155525	-	477	WP_187152920.1	pentapeptide repeat-containing protein	-
AM10699_RS18575 (AM10699_36510)	4155824..4156489	-	666	WP_012161499.1	class I SAM-dependent methyltransferase	-
AM10699_RS18580 (AM10699_36520)	4156718..4157509	+	792	WP_238549161.1	DUF2059 domain-containing protein	-
AM10699_RS18585 (AM10699_36530)	4157509..4158024	+	516	WP_063710512.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (21-98)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (4-76)

Sequences

Toxin

Protein

• Length: 99 a.a.
• Molecular weight: 11592.60 Da
• Isoelectric Point: 10.3683

>T41792 WP_012161495.1 NZ_AP026075:4153982-4154278 [Acaryochloris marina MBIC10699]
MGKKKAKFIPTEVKWEIILDQNFREDLQYWIQQDRKLALRLLAVVESIAINPFTGIGKPEALKHLGSNLWSRRLNQEHRI
VYLVRDGKVYLLAAKYHY

Nucleotide

• Length: 297 bp

>T41792 NZ_AP026075:4153982-4154278 [Acaryochloris marina MBIC10699]
TTGGGGAAGAAGAAGGCTAAGTTTATCCCTACTGAGGTCAAGTGGGAAATCATCCTTGATCAAAATTTTAGAGAAGATTT
GCAGTATTGGATTCAACAGGATCGGAAGCTGGCACTAAGGTTACTGGCTGTGGTTGAATCCATTGCCATAAATCCATTTA
CTGGCATTGGCAAGCCCGAAGCTCTTAAGCATCTAGGTTCTAATTTGTGGTCCCGACGCCTGAATCAAGAACACCGCATT
GTGTATCTTGTTCGGGATGGGAAAGTATATCTGCTAGCAGCAAAATATCACTATTAG

Antitoxin

Protein

• Length: 98 a.a.
• Molecular weight: 10557.78 Da
• Isoelectric Point: 4.1712

>AT41792 WP_012161494.1 NZ_AP026075:4153708-4154001 [Acaryochloris marina MBIC10699]
MLPKTLSYSQARANFAETLNDVEDNRSIVIVQRPNRPGVALIAADELSSMMETVHLLRSPANATRLFDAIARAEAGEGQP
TTLDELTQELGFGEEEG

Nucleotide

• Length: 294 bp

>AT41792 NZ_AP026075:4153708-4154001 [Acaryochloris marina MBIC10699]
ATGCTGCCAAAAACCCTTAGTTATAGTCAGGCTCGTGCTAATTTTGCAGAGACCCTGAATGATGTTGAAGACAATCGCTC
TATTGTCATTGTTCAACGTCCTAATCGACCCGGTGTGGCTTTAATTGCGGCAGATGAGCTGAGCAGCATGATGGAAACGG
TTCACCTACTGAGATCGCCCGCCAATGCCACCCGTCTCTTTGATGCGATCGCACGAGCTGAAGCGGGAGAAGGACAGCCC
ACTACTCTAGATGAACTCACCCAGGAGCTGGGCTTTGGGGAAGAAGAAGGCTAA

Structures

Toxin

• AlphaFold DB: B0BYN7

Antitoxin

• AlphaFold DB: B0BYN6