Detailed information of TA system TA041789

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PumA-relB/upstrm_HI1419-dnstrm_HI1420
• Location: 2136137..2136730
• Replicon: chromosome
• Accession: NZ_AP026075
• Organism: Acaryochloris marina MBIC10699

Toxin (Protein)

• Gene name: PumA
• Uniprot ID: B0C9N5
• Locus tag: AM10699_RS09455
• Protein ID: WP_012165444.1
• Coordinates: 2136137..2136433 (+)
• Length: 99 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: AM10699_RS09460
• Protein ID: WP_012165445.1
• Coordinates: 2136434..2136730 (+)
• Length: 99 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AM10699_RS09440 (AM10699_18900)	2131410..2133800	+	2391	WP_238549052.1	DUF11 domain-containing protein	-
AM10699_RS09445 (AM10699_18910)	2133849..2135060	-	1212	WP_261891378.1	saccharopine dehydrogenase NADP-binding domain-containing protein	-
AM10699_RS09450 (AM10699_18920)	2135205..2135495	+	291	WP_012165442.1	DUF2288 domain-containing protein	-
AM10699_RS09455 (AM10699_18930)	2136137..2136433	+	297	WP_012165444.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
AM10699_RS09460 (AM10699_18940)	2136434..2136730	+	297	WP_012165445.1	putative addiction module antidote protein	Antitoxin
AM10699_RS09465 (AM10699_18950)	2136930..2137361	+	432	WP_012165446.1	dUTP diphosphatase	-
AM10699_RS09470 (AM10699_18960)	2137449..2137721	-	273	WP_012165447.1	hypothetical protein	-
AM10699_RS09475 (AM10699_18970)	2138028..2140505	-	2478	WP_041660301.1	ATP-dependent DNA helicase RecG	-
AM10699_RS09480 (AM10699_18980)	2140540..2141070	-	531	WP_012165449.1	GNAT family N-acetyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Addiction module killer protein, predicted (3-95)

Antitoxin

• Uncharacterized protein HI1420 (7-94)

Sequences

Toxin

Protein

• Length: 99 a.a.
• Molecular weight: 11133.69 Da
• Isoelectric Point: 9.9108

>T41789 WP_012165444.1 NZ_AP026075:2136137-2136433 [Acaryochloris marina MBIC10699]
MIEVRQTDIFAKWFNNLRDRKAKARVQARIDRIEIGNFGDVAPVGEGVSELRIHYGPGYRVYFVQRDSVVVILLSGGDKS
SQNADIKRAKEIAKQLED

Nucleotide

• Length: 297 bp

>T41789 NZ_AP026075:2136137-2136433 [Acaryochloris marina MBIC10699]
ATGATTGAGGTTCGTCAAACGGACATTTTTGCCAAGTGGTTCAATAATCTGCGAGATCGCAAAGCTAAAGCTCGTGTACA
AGCACGTATTGACCGTATCGAGATTGGTAACTTTGGCGATGTTGCCCCTGTGGGAGAAGGCGTTAGCGAACTCCGCATTC
ACTATGGTCCGGGGTACAGGGTTTACTTTGTACAGCGCGATTCAGTTGTTGTCATCTTGCTCTCTGGTGGTGATAAAAGC
TCCCAAAATGCTGACATTAAAAGGGCTAAGGAAATTGCTAAACAGTTGGAGGATTGA

Antitoxin

Protein

• Length: 99 a.a.
• Molecular weight: 10667.22 Da
• Isoelectric Point: 4.7627

>AT41789 WP_012165445.1 NZ_AP026075:2136434-2136730 [Acaryochloris marina MBIC10699]
MMPISTTYWDSAAHLKTDEDIQLYLEACIEEAEDDPALIIHALGVVARAKNMSQLSRETGLSREGLYKALSVDGNPTFAT
IAKVTKALGFKLTIQPTA

Nucleotide

• Length: 297 bp

>AT41789 NZ_AP026075:2136434-2136730 [Acaryochloris marina MBIC10699]
ATGATGCCCATAAGCACAACCTATTGGGATTCTGCCGCACATCTCAAAACAGACGAAGATATTCAGCTCTACCTAGAAGC
CTGCATTGAAGAAGCAGAAGATGATCCTGCTTTAATTATTCATGCCCTAGGAGTTGTCGCCAGGGCGAAAAACATGAGTC
AACTCTCCCGAGAAACAGGTTTGAGTAGAGAGGGCCTATATAAAGCGCTGTCAGTTGATGGCAACCCCACGTTTGCGACT
ATCGCTAAAGTCACTAAAGCACTCGGATTCAAGCTAACCATTCAGCCAACGGCTTAG

Structures

Toxin

• AlphaFold DB: B0C9N5