Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumA-relB/upstrm_HI1419-dnstrm_HI1420
Location 5703896..5704489 Replicon chromosome
Accession NZ_AP025944
Organism Pseudomonas sp. LRP2-20

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag OCX61_RS25675 Protein ID WP_261944364.1
Coordinates 5704211..5704489 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag OCX61_RS25670 Protein ID WP_159412912.1
Coordinates 5703896..5704201 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OCX61_RS25650 (KMS_R50190) 5700025..5702262 + 2238 WP_261941888.1 AsmA family protein -
OCX61_RS25655 (KMS_R50200) 5702259..5703326 + 1068 WP_261941889.1 A/G-specific adenine glycosylase -
OCX61_RS25660 (KMS_R50210) 5703323..5703595 + 273 WP_261941890.1 oxidative damage protection protein -
OCX61_RS25670 (KMS_R50220) 5703896..5704201 - 306 WP_159412912.1 putative addiction module antidote protein Antitoxin
OCX61_RS25675 5704211..5704489 - 279 WP_261944364.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OCX61_RS25680 (KMS_R50240) 5704673..5705662 + 990 WP_261941891.1 polyphosphate kinase 2 -
OCX61_RS25685 (KMS_R50250) 5705833..5706276 + 444 WP_261941892.1 hypothetical protein -
OCX61_RS25690 (KMS_R50260) 5706506..5707891 - 1386 WP_261941893.1 GABA permease -
OCX61_RS25695 (KMS_R50270) 5708523..5709296 + 774 WP_085677911.1 ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(8-86)

Antitoxin

Uncharacterized protein HI1420

(3-96)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10463.12 Da        Isoelectric Point: 10.4276

>T41788 WP_261944364.1 NZ_AP025944:c5704489-5704211 [Pseudomonas sp. LRP2-20]
ITNRQLQKWFAALRDARAQARINVRLRWVELGVIGDCKPVGEGVSEMRIDYGPGYRVYFVQRGYEVIILLAGGDKSTQAR
DIRSALKLAREL

Download         Length: 279 bp

>T41788 NZ_AP025944:c5704489-5704211 [Pseudomonas sp. LRP2-20]
ATTACAAACCGACAGCTACAGAAGTGGTTCGCCGCGTTGCGGGATGCTCGTGCACAGGCTCGTATCAATGTGCGCTTGCG
GTGGGTCGAGCTTGGCGTGATTGGGGACTGTAAGCCGGTAGGTGAAGGAGTGTCCGAGATGCGGATCGATTACGGTCCGG
GCTATCGGGTGTATTTCGTTCAGCGAGGCTACGAGGTGATCATCCTTCTGGCGGGTGGCGACAAGTCCACTCAGGCCAGG
GATATCAGATCAGCCCTCAAGCTGGCACGCGAGCTTTAG

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 10810.45 Da        Isoelectric Point: 4.8307

>AT41788 WP_159412912.1 NZ_AP025944:c5704201-5703896 [Pseudomonas sp. LRP2-20]
MTDTKLTKWDAADHLKTEEDMALYLEACLEENDPVLLAAALGDIARARGMAQLARDTGLTREGLYKALSAEGNPSLATIM
KVMAALGLRLHAEVVSPRTAG

Download         Length: 306 bp

>AT41788 NZ_AP025944:c5704201-5703896 [Pseudomonas sp. LRP2-20]
ATGACTGATACCAAACTGACCAAGTGGGATGCCGCAGATCACCTCAAGACAGAGGAAGACATGGCTCTGTACCTCGAGGC
CTGCCTTGAAGAAAACGATCCAGTGCTGCTTGCCGCTGCCTTGGGCGATATCGCGCGTGCTCGTGGCATGGCACAGCTGG
CGCGTGATACGGGCCTGACTCGCGAAGGGTTATACAAAGCCTTGTCGGCGGAGGGTAACCCTAGCCTGGCGACCATCATG
AAAGTGATGGCGGCGCTCGGCCTGAGGTTACATGCCGAGGTGGTATCTCCGCGAACTGCGGGGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References