Detailed information of TA system TA041786

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relE-dinJ/YafQ-RelB
• Location: 4209346..4209877
• Replicon: chromosome
• Accession: NZ_AP025942
• Organism: Methylorubrum sp. GM97

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: MSPGM_RS19700
• Protein ID: WP_003605878.1
• Coordinates: 4209596..4209877 (+)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: dinJ
• Uniprot ID: C5B2A4
• Locus tag: MSPGM_RS19695
• Protein ID: WP_003605879.1
• Coordinates: 4209346..4209609 (+)
• Length: 88 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MSPGM_RS19670 (MSPGM_38940)	4204491..4205462	+	972	WP_003606981.1	quinone oxidoreductase	-
MSPGM_RS19675 (MSPGM_38950)	4205546..4206172	+	627	WP_003606982.1	bifunctional nicotinamidase/pyrazinamidase	-
MSPGM_RS19680 (MSPGM_38960)	4206183..4207040	-	858	WP_015857326.1	aminotransferase class IV	-
MSPGM_RS19685 (MSPGM_38970)	4207027..4207656	-	630	WP_003607382.1	aminodeoxychorismate/anthranilate synthase component II	-
MSPGM_RS19690 (MSPGM_38980)	4207653..4209053	-	1401	WP_015857327.1	aminodeoxychorismate synthase component I	-
MSPGM_RS19695 (MSPGM_38990)	4209346..4209609	+	264	WP_003605879.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
MSPGM_RS19700 (MSPGM_39000)	4209596..4209877	+	282	WP_003605878.1	type II toxin-antitoxin system YafQ family toxin	Toxin
MSPGM_RS19705 (MSPGM_39010)	4209994..4211340	+	1347	WP_003605876.1	30S ribosomal protein S12 methylthiotransferase RimO	-
MSPGM_RS19710 (MSPGM_39020)	4211437..4211622	+	186	WP_003605874.1	hypothetical protein	-
MSPGM_RS19715 (MSPGM_39030)	4211629..4212030	+	402	WP_003605873.1	DoxX family protein	-
MSPGM_RS19720 (MSPGM_39040)	4212119..4212310	+	192	WP_003605871.1	hypothetical protein	-
MSPGM_RS19725 (MSPGM_39050)	4212396..4213226	-	831	WP_043708089.1	nucleoside triphosphate pyrophosphohydrolase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (2-91)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-83)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10664.24 Da
• Isoelectric Point: 10.2159

>T41786 WP_003605878.1 NZ_AP025942:4209596-4209877 [Methylorubrum sp. GM97]
MRTIERTTQFKRDYKREMKGRHRASLQADLTAVLTELAADRPLAARLRDHALTGNWADHRDCHVKPDLVLIYRLAGTETL
QLVRLGSHAELGF

Nucleotide

• Length: 282 bp

>T41786 NZ_AP025942:4209596-4209877 [Methylorubrum sp. GM97]
ATGCGGACGATTGAGCGAACCACGCAGTTCAAGCGTGACTATAAGCGGGAGATGAAGGGCAGGCACCGGGCGAGCCTTCA
AGCCGACCTGACGGCGGTGCTGACCGAGTTGGCCGCGGATCGCCCCCTGGCGGCGCGCCTGCGCGACCACGCCCTGACCG
GCAACTGGGCCGACCATCGCGACTGCCACGTGAAGCCGGATCTGGTGCTGATCTATCGGCTTGCAGGAACGGAAACGCTC
CAATTGGTGCGCCTCGGCTCGCATGCCGAACTGGGCTTCTGA

Antitoxin

Protein

• Length: 88 a.a.
• Molecular weight: 9356.81 Da
• Isoelectric Point: 4.4230

>AT41786 WP_003605879.1 NZ_AP025942:4209346-4209609 [Methylorubrum sp. GM97]
MPTKSLIQARIDADTKEEATAVLKAMGLTVSDAVRMMLVRVAREKALPFEPLVPNETTIAAIREARSGNLPGFTSVEALM
ADLDADD

Nucleotide

• Length: 264 bp

>AT41786 NZ_AP025942:4209346-4209609 [Methylorubrum sp. GM97]
ATGCCGACCAAGTCGCTGATCCAGGCGCGGATCGATGCCGACACCAAGGAAGAGGCCACAGCCGTTCTCAAGGCCATGGG
GCTGACCGTCTCCGATGCGGTTCGCATGATGCTCGTGCGCGTCGCGCGCGAGAAGGCGCTTCCCTTCGAGCCTCTGGTTC
CCAACGAAACGACCATCGCAGCCATCCGCGAGGCGCGGTCCGGTAACCTTCCGGGCTTCACCAGCGTCGAGGCGCTGATG
GCCGATCTCGATGCGGACGATTGA

Structures

Antitoxin

• AlphaFold DB: C5B2A4