Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/upstrm_HI1419-dnstrm_HI1420
Location 3239002..3239594 Replicon chromosome
Accession NZ_AP025942
Organism Methylorubrum sp. GM97

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag MSPGM_RS14970 Protein ID WP_003599302.1
Coordinates 3239292..3239594 (-) Length 101 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag MSPGM_RS14965 Protein ID WP_080577052.1
Coordinates 3239002..3239292 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MSPGM_RS14945 (MSPGM_29460) 3234823..3235770 + 948 WP_244413741.1 fatty acid desaturase -
MSPGM_RS14950 (MSPGM_29470) 3235830..3237101 - 1272 WP_003599308.1 tyrosine--tRNA ligase -
MSPGM_RS14955 (MSPGM_29480) 3237242..3238375 + 1134 WP_003599307.1 anhydro-N-acetylmuramic acid kinase -
MSPGM_RS14960 (MSPGM_29490) 3238385..3239008 + 624 WP_003599306.1 DUF3578 domain-containing protein -
MSPGM_RS14965 (MSPGM_29500) 3239002..3239292 - 291 WP_080577052.1 putative addiction module antidote protein Antitoxin
MSPGM_RS14970 (MSPGM_29510) 3239292..3239594 - 303 WP_003599302.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MSPGM_RS14975 (MSPGM_29520) 3239716..3240816 + 1101 WP_003599300.1 chorismate synthase -
MSPGM_RS14980 (MSPGM_29530) 3240945..3242023 + 1079 Protein_2936 3,4-dihydroxy-2-butanone-4-phosphate synthase -
MSPGM_RS14985 (MSPGM_29550) 3242167..3243096 - 930 WP_043707076.1 histone deacetylase family protein -
MSPGM_RS14990 (MSPGM_29560) 3243397..3244032 + 636 WP_261925691.1 L,D-transpeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-90)

Antitoxin

Uncharacterized protein HI1420

(2-91)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11099.80 Da        Isoelectric Point: 10.2636

>T41785 WP_003599302.1 NZ_AP025942:c3239594-3239292 [Methylorubrum sp. GM97]
MPDIIRTRTFADWLKGLRDDRAKARIALRIDRLALGHEGDSKAVGGGVSELRIDYGPGYRIYFTYRGKTLVVLLCGGDKA
SQKRDISRAKTLATMLDGTE

Download         Length: 303 bp

>T41785 NZ_AP025942:c3239594-3239292 [Methylorubrum sp. GM97]
ATGCCGGACATCATCCGCACCCGAACGTTCGCGGATTGGCTGAAGGGGCTTCGGGACGATCGCGCAAAGGCACGGATCGC
GTTGCGGATCGATCGTCTTGCACTCGGCCATGAGGGTGATTCGAAAGCTGTCGGCGGTGGCGTCAGCGAATTGCGGATCG
ACTACGGACCGGGCTACCGGATCTACTTCACGTATCGTGGCAAGACCCTGGTCGTCCTGCTGTGCGGCGGGGACAAGGCG
AGCCAGAAGCGCGACATTTCCCGAGCGAAGACCTTGGCGACGATGCTGGACGGAACGGAATGA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10256.38 Da        Isoelectric Point: 4.3440

>AT41785 WP_080577052.1 NZ_AP025942:c3239292-3239002 [Methylorubrum sp. GM97]
MTETSPYDSAEFLESDEAVAEYLAAAIEEGDAALFRRALGVAARARGMTQIARETGLSRESLYRALSDDGNPSLDTALRV
LNALNVRLTASVASPH

Download         Length: 291 bp

>AT41785 NZ_AP025942:c3239292-3239002 [Methylorubrum sp. GM97]
ATGACGGAAACCAGCCCCTACGACTCGGCCGAATTCCTGGAAAGCGATGAGGCGGTTGCCGAATATCTGGCTGCGGCCAT
CGAAGAAGGAGACGCTGCGCTGTTTCGCCGGGCGCTCGGTGTCGCGGCCCGCGCGCGTGGCATGACTCAGATCGCTCGCG
AGACAGGTTTATCGCGGGAAAGCCTCTATCGGGCGTTGTCGGACGACGGCAATCCGAGCCTCGACACGGCTCTGCGCGTC
CTCAATGCCTTGAACGTCCGCCTGACGGCATCGGTCGCCTCTCCTCACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References