Detailed information of TA system TA041783

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relE-yefM/Txe-RelB
• Location: 3784134..3784657
• Replicon: chromosome
• Accession: NZ_AP025941
• Organism: Paraprevotella clara strain 1C4

Toxin (Protein)

• Gene name: relE
• Uniprot ID: G5SVT3
• Locus tag: QMG02_RS14770
• Protein ID: WP_008622666.1
• Coordinates: 3784385..3784657 (+)
• Length: 91 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: QMG02_RS14765
• Protein ID: WP_281795268.1
• Coordinates: 3784134..3784394 (+)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
QMG02_RS14760 (PC1C4_28390)	3780210..3783866	-	3657	WP_281795266.1	hypothetical protein	-
QMG02_RS14765 (PC1C4_28400)	3784134..3784394	+	261	WP_281795268.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
QMG02_RS14770 (PC1C4_28410)	3784385..3784657	+	273	WP_008622666.1	Txe/YoeB family addiction module toxin	Toxin
QMG02_RS14775 (PC1C4_28420)	3785239..3785922	-	684	WP_281795272.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	3576580..3890399	313819

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (8-87)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-73)

Sequences

Toxin

Protein

• Length: 91 a.a.
• Molecular weight: 10601.23 Da
• Isoelectric Point: 9.4442

>T41783 WP_008622666.1 NZ_AP025941:3784385-3784657 [Paraprevotella clara]
MEIIFLGQAEKDREYWKKSGNKAIMNKITALLKDIAEHPYTGIGKPEPLKYELAGYWSRRINSEHRIVYSVDEEVVRVYV
LSIRYYYAGK

Nucleotide

• Length: 273 bp

>T41783 NZ_AP025941:3784385-3784657 [Paraprevotella clara]
ATGGAAATAATATTTCTGGGACAAGCGGAAAAAGACAGGGAATATTGGAAGAAGTCCGGGAACAAAGCCATAATGAACAA
AATAACCGCTTTACTTAAAGACATTGCCGAACATCCATACACCGGCATAGGCAAACCTGAACCATTAAAATATGAATTGG
CCGGATACTGGTCGCGCCGCATCAATTCGGAGCACCGTATCGTTTATTCGGTCGACGAAGAGGTGGTGAGGGTGTATGTG
CTTTCCATAAGATACTATTACGCCGGGAAATAG

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9762.06 Da
• Isoelectric Point: 4.8550

>AT41783 WP_281795268.1 NZ_AP025941:3784134-3784394 [Paraprevotella clara]
MRTANYSELRNNLKHYLDGVINDSEPLLVHRPGNESVVVMSLDEYNSIKETEYIIKSPAIMDAIRKGAEEIKEGKGTAVN
IDELWK

Nucleotide

• Length: 261 bp

>AT41783 NZ_AP025941:3784134-3784394 [Paraprevotella clara]
ATGAGGACTGCTAATTATTCTGAACTGAGAAACAACCTGAAACATTACCTTGACGGGGTAATCAATGACAGCGAGCCGCT
GTTGGTACACCGTCCGGGCAATGAGAGCGTGGTTGTCATGTCTTTGGACGAATACAACTCCATCAAAGAGACCGAATATA
TCATAAAATCTCCGGCCATAATGGACGCCATCAGGAAAGGAGCGGAAGAAATCAAAGAAGGTAAAGGGACGGCCGTAAAT
ATTGATGAATTATGGAAATAA