Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 953347..953845 Replicon chromosome
Accession NZ_AP025940
Organism Streptococcus pneumoniae strain PZ900700204

Toxin (Protein)


Gene name relE Uniprot ID B1IC19
Locus tag QMM33_RS04895 Protein ID WP_001809704.1
Coordinates 953591..953845 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID B1IC20
Locus tag QMM33_RS04890 Protein ID WP_000208080.1
Coordinates 953347..953589 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QMM33_RS04865 948947..949072 - 126 WP_001818232.1 hypothetical protein -
QMM33_RS04870 (PC0204_09530) 949169..950344 + 1176 WP_000886145.1 A/G-specific adenine glycosylase -
QMM33_RS04875 (PC0204_09540) 950399..951103 + 705 WP_000722076.1 response regulator YycF -
QMM33_RS04880 (PC0204_09550) 951096..952445 + 1350 WP_000886210.1 cell wall metabolism sensor histidine kinase VicK -
QMM33_RS04885 (PC0204_09560) 952447..953256 + 810 WP_001289493.1 MBL fold metallo-hydrolase -
QMM33_RS04890 (PC0204_09570) 953347..953589 + 243 WP_000208080.1 DUF6290 family protein Antitoxin
QMM33_RS04895 (PC0204_09580) 953591..953845 + 255 WP_001809704.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QMM33_RS04900 (PC0204_09590) 953920..955791 + 1872 WP_000150986.1 Eco57I restriction-modification methylase domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(7-84)

Antitoxin

Protein of unknown function DUF6290

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10098.79 Da        Isoelectric Point: 10.7632

>T41780 WP_001809704.1 NZ_AP025940:953591-953845 [Streptococcus pneumoniae]
MYKLVPTRRFIKQLKKLDRYTQKLITNYLQTNVLEDPRRHGKALVGNRVGQWRYRIGNYRVIVQIVDDELVVATLEVGHR
RDIY

Download         Length: 255 bp

>T41780 NZ_AP025940:953591-953845 [Streptococcus pneumoniae]
TTGTATAAATTAGTTCCAACAAGACGTTTTATCAAGCAATTGAAAAAATTGGACCGTTATACGCAGAAGCTAATTACAAA
CTATTTACAAACCAATGTTTTGGAAGACCCAAGACGACACGGAAAGGCTTTGGTTGGTAATCGCGTTGGTCAATGGCGCT
ATAGAATTGGTAATTATCGAGTTATCGTACAAATTGTAGATGATGAATTAGTCGTTGCTACTCTAGAAGTTGGTCATCGG
AGAGATATTTATTGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9205.46 Da        Isoelectric Point: 4.0527

>AT41780 WP_000208080.1 NZ_AP025940:953347-953589 [Streptococcus pneumoniae]
MTTITLKVSEADKTFMKAMAKFEGVSLSELIRTKTLEALEDEYDARVADLAYQEYLEDLEKGVEPITWEEMMHDLGLKDE

Download         Length: 243 bp

>AT41780 NZ_AP025940:953347-953589 [Streptococcus pneumoniae]
ATGACTACTATTACATTAAAAGTTTCTGAAGCTGATAAAACATTTATGAAAGCAATGGCTAAGTTTGAAGGAGTTTCCCT
TTCGGAACTTATTCGCACCAAAACTCTTGAAGCCCTAGAAGATGAATACGATGCTCGTGTGGCAGATTTAGCCTATCAAG
AGTATTTAGAAGACTTGGAAAAAGGAGTTGAACCCATTACTTGGGAAGAAATGATGCATGATTTAGGCTTGAAGGATGAA
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A853PEW4

Antitoxin

Source ID Structure
AlphaFold DB A0A064C2J7

References