Detailed information of TA system TA041777

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): pezAT/zeta-couple_hipB
• Location: 1065880..1067132
• Replicon: chromosome
• Accession: NZ_AP025939
• Organism: Streptococcus pneumoniae strain Utah_35B-24

Toxin (Protein)

• Gene name: pezT
• Uniprot ID: A0A4J2GTV6
• Locus tag: QMM27_RS05255
• Protein ID: WP_000405373.1
• Coordinates: 1065880..1066656 (-)
• Length: 259 a.a.

Antitoxin (Protein)

• Gene name: pezA
• Uniprot ID: -
• Locus tag: QMM27_RS05260
• Protein ID: WP_000579602.1
• Coordinates: 1066656..1067132 (-)
• Length: 159 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
QMM27_RS05240 (Utah35B_10350)	1061086..1061982	-	897	WP_000161642.1	restriction endonuclease	-
QMM27_RS05245 (Utah35B_10360)	1062007..1065030	-	3024	WP_001858282.1	DEAD/DEAH box helicase	-
QMM27_RS05250 (Utah35B_10370)	1065087..1065896	-	810	WP_000413878.1	SAVED domain-containing protein	-
QMM27_RS05255 (Utah35B_10380)	1065880..1066656	-	777	WP_000405373.1	type II toxin-antitoxin system toxin PezT	Toxin
QMM27_RS05260 (Utah35B_10390)	1066656..1067132	-	477	WP_000579602.1	type II toxin-antitoxin system antitoxin PezA	Antitoxin
QMM27_RS05265 (Utah35B_10400)	1067577..1068032	-	456	WP_000500478.1	hypothetical protein	-
QMM27_RS05270 (Utah35B_10420)	1068307..1070046	-	1740	Protein_1043	glycoside hydrolase family 13 protein	-
QMM27_RS05275 (Utah35B_10430)	1070209..1071093	-	885	WP_000710117.1	diacylglycerol kinase family lipid kinase	-
QMM27_RS05280	1071205..1072059	-	855	Protein_1045	ADP-ribosylglycohydrolase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	1061086..1082364	21278

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Zeta toxin domain (25-215)

Antitoxin

• Cro/C1-type helix-turn-helix domain (3-60)

Sequences

Toxin

Protein

• Length: 259 a.a.
• Molecular weight: 29509.43 Da
• Isoelectric Point: 6.9224

>T41777 WP_000405373.1 NZ_AP025939:c1066656-1065880 [Streptococcus pneumoniae]
MEIQDYTDSEFKHALARNLRSLTRGKKSSKQSIAILLGGQSGAGKTTIHRIKQKEFQGNIVIIDGDSFRSQHPHYLELQQ
ENGKDSVEYTKDFAGKMVESLVTELSHLGYNLLIEGTLRTIDVPKKTAQLLKNKGYEVQLALIATKPELSYLSTLIRYEE
LYAINPNPARATPKEHHDFIVNHLVDNTRQLEELAIFERIQIYQRDRSCVYDSKENTTSAAEVLQEYLFGKWSKVEEEML
KVGEERMRDMSKSNGKDA

Nucleotide

• Length: 777 bp

>T41777 NZ_AP025939:c1066656-1065880 [Streptococcus pneumoniae]
ATGGAAATCCAAGATTATACTGATAGTGAATTCAAACATGCTTTAGCAAGGAATCTTCGTTCACTGACAAGAGGAAAAAA
GTCCAGTAAACAATCTATAGCGATTTTGCTTGGAGGTCAAAGTGGTGCCGGTAAGACTACAATTCATCGTATTAAACAGA
AAGAATTTCAAGGAAATATTGTTATCATAGATGGTGATAGTTTTCGTTCTCAGCATCCACACTATTTAGAACTGCAGCAA
GAAAATGGCAAAGATAGCGTTGAATACACCAAAGATTTTGCAGGGAAAATGGTAGAGTCTTTAGTAACCGAATTGAGTCA
TTTGGGATACAATCTTTTGATAGAGGGAACTTTACGAACTATTGATGTTCCAAAGAAAACAGCACAACTATTAAAAAATA
AGGGGTATGAGGTACAATTAGCCTTAATTGCAACCAAGCCCGAATTGTCCTATCTGAGCACCCTTATCCGATACGAAGAA
CTGTATGCTATCAATCCAAATCCAGCACGCGCAACTCCAAAAGAACATCATGATTTCATTGTAAATCATCTAGTTGATAA
TACACGACAATTGGAAGAACTAGCTATTTTTGAAAGAATTCAAATTTACCAACGAGATAGAAGTTGTGTATATGATTCAA
AAGAAAATACAACTTCAGCAGCAGAAGTGCTACAAGAATACCTCTTCGGAAAATGGAGCAAGGTAGAGGAAGAGATGTTG
AAGGTGGGAGAAGAACGGATGAGGGATATGAGTAAAAGTAATGGAAAAGATGCATAG

Antitoxin

Protein

• Length: 159 a.a.
• Molecular weight: 18289.70 Da
• Isoelectric Point: 4.4188

>AT41777 WP_000579602.1 NZ_AP025939:c1067132-1066656 [Streptococcus pneumoniae]
MIGKNIKSLRKTHDLTQHEFARIIGISRNSLSRYENGTSSVSTELIDIICQKFNVSYVDIVGEDKMLNPVEDYELTLKIE
IVKERGANLLSRLYRYQDSQGISIDDESNPWILMSDDLSDLIQTNIYLVENFDEIERYSGYLDGIERMLEISEKRMVA

Nucleotide

• Length: 477 bp

>AT41777 NZ_AP025939:c1067132-1066656 [Streptococcus pneumoniae]
ATGATTGGAAAAAACATAAAATCCTTACGTAAAACACATGACTTAACACAACACGAATTTGCACGAATTATAGGAATTTC
TCGAAATAGCTTGAGTCGTTATGAAAATGGAACTAGTTCAGTCTCTACGGAATTAATTGACATCATTTGTCAGAAGTTTA
ATGTATCTTATGTCGATATTGTAGGAGAAGATAAAATGCTCAATCCTGTTGAAGATTATGAATTGACTTTGAAAATTGAA
ATTGTGAAAGAAAGAGGTGCTAATCTATTATCTCGACTCTATCGTTATCAAGATAGTCAGGGAATTAGCATTGATGATGA
ATCTAATCCTTGGATTTTAATGAGTGATGATCTATCTGACTTGATTCAGACAAATATCTATTTAGTAGAAAATTTTGATG
AAATAGAGAGATATAGCGGCTATTTGGATGGAATTGAACGTATGTTAGAGATATCTGAAAAGCGGATGGTAGCTTAA

Structures

Toxin

• AlphaFold DB: A0A4J2GTV6