Detailed information of TA system TA041776

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE(toxin)
• Location: 920764..921262
• Replicon: chromosome
• Accession: NZ_AP025939
• Organism: Streptococcus pneumoniae strain Utah_35B-24

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: QMM27_RS04625
• Protein ID: WP_001812387.1
• Coordinates: 921008..921262 (+)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: B1IC20
• Locus tag: QMM27_RS04620
• Protein ID: WP_000208080.1
• Coordinates: 920764..921006 (+)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
QMM27_RS04600 (Utah35B_09090)	916586..917761	+	1176	WP_000886147.1	A/G-specific adenine glycosylase	-
QMM27_RS04605 (Utah35B_09100)	917816..918520	+	705	WP_000722076.1	response regulator YycF	-
QMM27_RS04610 (Utah35B_09110)	918513..919862	+	1350	WP_000886210.1	cell wall metabolism sensor histidine kinase VicK	-
QMM27_RS04615 (Utah35B_09120)	919864..920673	+	810	WP_001289493.1	MBL fold metallo-hydrolase	-
QMM27_RS04620 (Utah35B_09130)	920764..921006	+	243	WP_000208080.1	DUF6290 family protein	Antitoxin
QMM27_RS04625 (Utah35B_09140)	921008..921262	+	255	WP_001812387.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
QMM27_RS04630 (Utah35B_09150)	921309..922083	+	775	Protein_915	ion channel	-
QMM27_RS04635 (Utah35B_09160)	922346..923332	-	987	WP_000204727.1	L-lactate dehydrogenase	-
QMM27_RS04640 (Utah35B_09170)	923526..925994	+	2469	WP_001152989.1	DNA gyrase subunit A	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (7-84)

Antitoxin

• Protein of unknown function DUF6290 (1-73)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 10110.85 Da
• Isoelectric Point: 10.7632

>T41776 WP_001812387.1 NZ_AP025939:921008-921262 [Streptococcus pneumoniae]
MYKLVPTRRFIKQLKKLDRYTQKLITNYLQINVLEDPRRHGKALVGNRVGQWRYRIGNYRVIVQIVDDELVVATLEVGHR
RDIY

Nucleotide

• Length: 255 bp

>T41776 NZ_AP025939:921008-921262 [Streptococcus pneumoniae]
TTGTATAAATTAGTTCCAACAAGACGTTTCATCAAGCAATTGAAAAAATTGGACCGTTATACGCAGAAGCTAATTACAAA
CTATTTACAAATCAATGTTTTGGAAGACCCAAGACGACACGGAAAGGCTTTGGTTGGTAATCGCGTTGGTCAATGGCGCT
ATAGAATTGGTAATTATCGAGTTATCGTACAAATTGTAGATGATGAATTAGTTGTTGCTACTCTAGAAGTTGGTCATCGG
AGAGATATTTATTGA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9205.46 Da
• Isoelectric Point: 4.0527

>AT41776 WP_000208080.1 NZ_AP025939:920764-921006 [Streptococcus pneumoniae]
MTTITLKVSEADKTFMKAMAKFEGVSLSELIRTKTLEALEDEYDARVADLAYQEYLEDLEKGVEPITWEEMMHDLGLKDE

Nucleotide

• Length: 243 bp

>AT41776 NZ_AP025939:920764-921006 [Streptococcus pneumoniae]
ATGACTACTATTACATTAAAAGTTTCTGAAGCTGATAAAACATTTATGAAAGCAATGGCTAAGTTTGAAGGAGTTTCCCT
TTCGGAACTTATTCGCACCAAAACTCTTGAAGCCCTAGAAGATGAATACGATGCTCGTGTGGCAGATTTAGCCTATCAAG
AGTATTTAGAAGACTTGGAAAAAGGAGTTGAACCCATTACTTGGGAAGAAATGATGCATGATTTAGGCTTGAAGGATGAA
TAA

Structures

Antitoxin

• AlphaFold DB: A0A064C2J7